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Effects of 3-Hydroxypyridine and Succinic Acid Derivatives on Monoamine Oxidase Activity In Vitro

  • MOLECULAR BIOLOGICAL PROBLEMS OF DRUG DESIGN AND MECHANISM OF DRUG ACTION
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Pharmaceutical Chemistry Journal Aims and scope

The effects of original Russian 3-hydroxypyridine and succinic acid derivatives (emoxypine, Reamberin, and Mexidol) on monoamine oxidase (MAO-A and MAO-B) activity in rat liver were studied in vitro. The study drugs used in vitro at concentrations in the pharmacokinetic range (10 9 to 10 6 M), were found to have MAO-modulating actions, the directions depending on their chemical structural properties. The isolated 3-hydroxypyridine derivative emoxypine decreased MAO-A activity by 34 – 44% and MAO-B activity by 9 – 10% (p < 0.05 in both cases). The succinic acid derivative Reamberin increased MAO-A activity by 2-3% and MAO-B activity by 14% (p < 0.05 in both cases). Mexidol, which is a derivative of both 3-hydroxypyridine and succinic acid, decreased MAO-A activity by 13% and MAO-B activity by 4% (p < 0.05 in both cases). The 2-ethyl-3-methyl-3-hydroxypyridinium cation and the succinate anion were antagonists in terms of their MAO-modulating actions. Combining these antagonist ions into the structure of Mexidol led to complete loss of the MAO-stimulating effect of the succinate part and a significant reduction in the MAO-inhibiting action of the 3-hydroxypyridine component.

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Authors and Affiliations

  1. Southern Urals State Medical University, Ministry of Health of the Russian Federation, 64 Vorovskii Street, 454092, Chelyabinsk, Russia

    I. A. Volchegorskii, A. I. Sinitskii, I. Yu. Miroshnichenko & L. M. Rassokhina

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  1. I. A. Volchegorskii
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  2. A. I. Sinitskii
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  3. I. Yu. Miroshnichenko
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  4. L. M. Rassokhina
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Correspondence to I. A. Volchegorskii.

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 52, No. 1, pp. 3 – 7, January, 2018.

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Volchegorskii, I.A., Sinitskii, A.I., Miroshnichenko, I.Y. et al. Effects of 3-Hydroxypyridine and Succinic Acid Derivatives on Monoamine Oxidase Activity In Vitro. Pharm Chem J 52, 26–29 (2018). https://doi.org/10.1007/s11094-018-1760-2

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  • DOI: https://doi.org/10.1007/s11094-018-1760-2

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