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Influence of 2-Ethyl-6-Methyl-3-Hydroxypyridine on the Functional State of Rat Liver Mitochondria In Vitro

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Pharmaceutical Chemistry Journal Aims and scope

The influence of 2-ethyl-6-methyl-3-hydroxypyridine hydrochloride on the in vitro free-radical oxidation and respiration of intact rat liver mitochondria was studied. The drug used at a concentration within the pharmacokinetic range had a modulating effect on lipid peroxidation and oxidative modification of mitochondrial proteins. Emoxypine hydrochloride caused transient accumulation of lipid peroxidation products at relatively high concentrations in the incubation mixture (~10–3 M) and redistribution of free-radical oxidation substrates in favor of proteins with a gradual restriction of oxidative phosphorylation, a decrease in affinity of the respiratory chain to ADP, and an impaired intactness of mitochondrial structures reaching the most significant values at emoxypine hydrochloride concentrations of 10–8 and 10–9 M.

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Acknowledgments

The work was performed in the framework of a state task for scientific research and development on Pharmacophysiology and Biochemical Pharmacology of Derivatives of 3-Hydroxypyridine and Succinic Acid (State Reg. No. AAAA-A18-118021890008-4; Registration date, Feb. 18, 2018).

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Authors and Affiliations

  1. South Ural State Medical University, Ministry of Health of the Russian Federation, Chelyabinsk, 454092, Russia

    A. I. Sinitskii, O. T. Kochkina & S. I. Grobovoi

Authors
  1. A. I. Sinitskii
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  2. O. T. Kochkina
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  3. S. I. Grobovoi
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Correspondence to O. T. Kochkina.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 55, No. 1, pp. 8 – 12, January, 2021.

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Sinitskii, A.I., Kochkina, O.T. & Grobovoi, S.I. Influence of 2-Ethyl-6-Methyl-3-Hydroxypyridine on the Functional State of Rat Liver Mitochondria In Vitro. Pharm Chem J 55, 6–10 (2021). https://doi.org/10.1007/s11094-021-02362-8

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  • DOI: https://doi.org/10.1007/s11094-021-02362-8

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