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Journal of Cell Communication and Signaling

, Volume 9, Issue 3, pp 267–278 | Cite as

The role of CCN family genes in haematological malignancies

  • J. E. Wells
  • M. Howlett
  • L. C. Cheung
  • Ursula R. Kees
Review

Abstract

Haematological malignancies, although a broad range of specific disease types, continue to show considerable overlap in classification, and patients are treated using similar chemotherapy regimes. In this review we look at the role of the CCN family of matricellular proteins and indicate their role in nine haematological malignancies including both myeloid and lymphoid neoplasms. The potential for further haematological neoplasms with CCN family associations is argued by summarising the demonstrated role of CCN family genes in the differentiation of haematopoietic stem cells (HSC) and mesenchymal stem cells. The expanding field of knowledge encompassing CCN family genes and cancers of the HSC-lineage highlights the importance of extracellular matrix-interactions in both normal physiology and tumorigenesis of the blood, bone marrow and lymph nodes.

Keywords

CCN Cancer Haematopoietic stem cell (HSC) Mesenchymal stem cell (MSC) 

Abbreviations

ALL

Acute lymphoblastic leukaemia

AML

Acute myeloid leukaemia

Bax

Bcl-2-associated X protein

Bcl-xl

B-cell lymphoma- extra large

BMP

Bone morphogenic protein

CML

Chronic myeloid leukaemia

CDKN1B

Cyclin independent kinase inhibitor protein 27

CLP

Common lymphoid progenitors

CMP

Common myeloid progenitor

CTGF/CCN2

Connective tissue growth factor

CYR61/CCN1

Cysteine-rich 61

DLCBL

Diffuse large B-cell lymphoma

Dlk

Delta like kinase

ECM

Extracellular matrix

ELISA

Enzyme-linked immunosorbent assays

FSP1

Fibroblast-specific protein 1

HSC

Haematopoietic stem cell

IGFBP

Insulin-like growth factor-binding proteins

LRP

Low-density lipoprotein receptor-related protein

MCIJ

Monitoring of Cancer Incidence in Japan

MMP

Matrix metalloproteinase

MPP

Multipotent progenitor

MSC

Mesenchymal stem cell

NOV/CCN3 NOV

Nephroblastoma overexpressed

RBC

Red blood cell

SEER

Surveillance, epidemiology and end results program (SEER)

TGFβ

Transforming growth factor β

TRAIL

TNF-related apoptosis-inducing ligand 1

TrkA

Tropomyosin receptor kinase A

TSR

Thrombospondin type 1 repeat

VEGF

Vascular endothelial growth factor

VWC

Von Willebrand factor C

WISP-1/CCN4

Wnt-inducible-secreted protein 1

WISP-2/CCN5

Wnt-inducible-secreted protein 2

WISP-3/CCN6

Wnt-inducible-secreted protein 3

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Copyright information

© The International CCN Society 2015

Authors and Affiliations

  • J. E. Wells
    • 1
  • M. Howlett
    • 1
  • L. C. Cheung
    • 1
  • Ursula R. Kees
    • 1
  1. 1.Telethon Kids InstituteThe University of Western AustraliaPerthAustralia

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