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The role of CCN family genes in haematological malignancies

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  • Published:
Journal of Cell Communication and Signaling Aims and scope

Abstract

Haematological malignancies, although a broad range of specific disease types, continue to show considerable overlap in classification, and patients are treated using similar chemotherapy regimes. In this review we look at the role of the CCN family of matricellular proteins and indicate their role in nine haematological malignancies including both myeloid and lymphoid neoplasms. The potential for further haematological neoplasms with CCN family associations is argued by summarising the demonstrated role of CCN family genes in the differentiation of haematopoietic stem cells (HSC) and mesenchymal stem cells. The expanding field of knowledge encompassing CCN family genes and cancers of the HSC-lineage highlights the importance of extracellular matrix-interactions in both normal physiology and tumorigenesis of the blood, bone marrow and lymph nodes.

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Abbreviations

ALL:

Acute lymphoblastic leukaemia

AML:

Acute myeloid leukaemia

Bax:

Bcl-2-associated X protein

Bcl-xl:

B-cell lymphoma- extra large

BMP:

Bone morphogenic protein

CML:

Chronic myeloid leukaemia

CDKN1B:

Cyclin independent kinase inhibitor protein 27

CLP:

Common lymphoid progenitors

CMP:

Common myeloid progenitor

CTGF/CCN2:

Connective tissue growth factor

CYR61/CCN1:

Cysteine-rich 61

DLCBL:

Diffuse large B-cell lymphoma

Dlk:

Delta like kinase

ECM:

Extracellular matrix

ELISA:

Enzyme-linked immunosorbent assays

FSP1:

Fibroblast-specific protein 1

HSC:

Haematopoietic stem cell

IGFBP:

Insulin-like growth factor-binding proteins

LRP:

Low-density lipoprotein receptor-related protein

MCIJ:

Monitoring of Cancer Incidence in Japan

MMP:

Matrix metalloproteinase

MPP:

Multipotent progenitor

MSC:

Mesenchymal stem cell

NOV/CCN3 NOV:

Nephroblastoma overexpressed

RBC:

Red blood cell

SEER:

Surveillance, epidemiology and end results program (SEER)

TGFβ:

Transforming growth factor β

TRAIL:

TNF-related apoptosis-inducing ligand 1

TrkA:

Tropomyosin receptor kinase A

TSR:

Thrombospondin type 1 repeat

VEGF:

Vascular endothelial growth factor

VWC:

Von Willebrand factor C

WISP-1/CCN4:

Wnt-inducible-secreted protein 1

WISP-2/CCN5:

Wnt-inducible-secreted protein 2

WISP-3/CCN6:

Wnt-inducible-secreted protein 3

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Authors and Affiliations

  1. Telethon Kids Institute, The University of Western Australia, PO Box 855 West Perth, Perth, Western Australia, 6872, Australia

    J. E. Wells, M. Howlett, L. C. Cheung & Ursula R. Kees

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  1. J. E. Wells
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  2. M. Howlett
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  3. L. C. Cheung
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  4. Ursula R. Kees
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Correspondence to Ursula R. Kees.

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Wells, J.E., Howlett, M., Cheung, L.C. et al. The role of CCN family genes in haematological malignancies. J. Cell Commun. Signal. 9, 267–278 (2015). https://doi.org/10.1007/s12079-015-0296-4

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  • DOI: https://doi.org/10.1007/s12079-015-0296-4

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