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CCN5: biology and pathophysiology

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Journal of Cell Communication and Signaling Aims and scope

Abstract

CCN5 is one of six proteins in the CCN family. This family of proteins has been shown to play important roles in many processes, including proliferation, migration, adhesion, extracellular matrix regulation, angiogenesis, tumorigenesis, fibrosis, and implantation. In this review, we focus on the biological and putative pathophysiological roles of CCN5. This intriguing protein is structurally unique among the CCN family members, and has a unique biological activity profile as well.

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Authors and Affiliations

  1. Program in Cell, Molecular and Developmental Biology, Tufts University Sackler School of Graduate Biomedical Sciences, 136 Harrison Avenue, Boston, MA, 02111, USA

    Joshua W. Russo & John J. Castellot Jr.

  2. Department of Anatomy and Cell Biology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA, 02111, USA

    John J. Castellot Jr.

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  1. Joshua W. Russo
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  2. John J. Castellot Jr.
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Correspondence to John J. Castellot Jr..

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Russo, J.W., Castellot, J.J. CCN5: biology and pathophysiology. J. Cell Commun. Signal. 4, 119–130 (2010). https://doi.org/10.1007/s12079-010-0098-7

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  • DOI: https://doi.org/10.1007/s12079-010-0098-7

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