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Segregation models of complex quantitative traits and linkage analysis in extended diallel crosses in a panel of recombinant inbred strains

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Russian Journal of Genetics: Applied Research

Abstract

Classes of segregation models that describe the character of the quantitative trait inheritance are presented for extended nonreciprocal diallel crosses of recombinant inbred strains. The use of the multilocus approach and accounting of epistatic interactions between the groups of loci are a distinctive feature of this study. Search for solutions that describe the experimental data up to environmental variance is performed in the constructed model classes. The linkage analysis (that is, determination of the position of the model loci for the found solutions on the chromosome genetic map) is subsequently performed. Approbation of the search procedure in the model space and of the approach to linkage analysis was performed on real data, where the cerebellum weight in laboratory mice acted as a quantitative trait. A short description of the implemented software is given.

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Authors and Affiliations

  1. Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia

    M. S. Diakov & A. V. Osadchuk

Authors
  1. M. S. Diakov
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  2. A. V. Osadchuk
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Correspondence to M. S. Diakov.

Additional information

Original Russian Text © M.S. Diakov, A.V. Osadchuk, 2013, published in Vavilovskii Zhurnal Genetiki i Selektsii, 2013, Vol. 17, No. 4/1, pp. 705–713.

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Diakov, M.S., Osadchuk, A.V. Segregation models of complex quantitative traits and linkage analysis in extended diallel crosses in a panel of recombinant inbred strains. Russ J Genet Appl Res 4, 318–324 (2014). https://doi.org/10.1134/S2079059714040030

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  • DOI: https://doi.org/10.1134/S2079059714040030

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