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Effect of Hypercapnia and Hypoxia on the Physiology and Metabolism of the Cerebral Endothelium under Ischemic Conditions

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Abstract

The review addresses the role of blood–brain barrier (BBB) dysfunction in neurological pathology, and describes epigenetic and metabolic regulators of its functional activity and structural integrity. It also provides information on the neuroprotective effects of hypoxia and hypercapnia with an assessment of their impact on the functioning of the BBB. In addition, the review provides arguments for the co-administration of drugs, which modulate BBB metabolism and permeability, and hypercapnic hypoxia to achieve a higher neuroprotective efficacy. The provided data demonstrate that there is a significant number of drugs with a high potential to increase neuroprotective efficacy when combined with hypercapnic hypoxia. These drugs include antioxidants, endothelial cell and membrane protectors, JNK inhibitors, and energotropic drugs.

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Funding

The writing of this review was state budget funded.

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Authors and Affiliations

  1. Research Center of Neurology, Moscow, Russia

    P. P. Tregub

  2. N.V. Sklifosovsky Research Institute of Emergency Medicine, Moscow, Russia

    P. P. Tregub

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Translated by A. Polyanovsky

Russian Text © The Author(s), 2022, published in Rossiiskii Fiziologicheskii Zhurnal imeni I.M. Sechenova, 2022, Vol. 108, No. 5, pp. 579–593https://doi.org/10.31857/S0869813922050120.

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Tregub, P.P. Effect of Hypercapnia and Hypoxia on the Physiology and Metabolism of the Cerebral Endothelium under Ischemic Conditions. J Evol Biochem Phys 58, 769–780 (2022). https://doi.org/10.1134/S0022093022030127

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