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Effect of Trimethoprim Drug Dose on Corrosion Behavior of Stainless Steel in Simulated Human Body Environment: Experimental and Theoretical Investigations

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Abstract

Stainless steel alloy is the most used material as orthopaedic implants. It has an excellent mechanical properties and low costs compared with other metals. It is still one of the most used materials for impermanent and permanent implants, especially in developing countries. Nevertheless, most of researches regarding stainless steel implants focused on the influence of human body fluids on stainless steel anticorrosive and bioactive properties of its surface. Limited researches took into consideration the effect of drugs on stainless steel implants. In this work, the corrosion of stainless-steel implants in human body fluid was investigated using experimental electrochemical technique and theoretical quantum chemical analysis. Gaussian 09 software with 6-311G(d,p) basis set was used during theoretical study. The influence of Trimethoprim (TMP) drug on stainless-steel corrosion behavior was also addressed. The results showed that corrosion current density of stainless steel increased with temperature and decreased with TMP concentration. Maximum inhibition efficiency of TMP was 95% at higher level of temperature and TMP concentration. Density functional theory was used as theoretical tool to predict the inhibition performance of TMP. A comparison between ground and protonated states of TMP was optimized and characterized. Furthermore, quantum chemical parameters of highest occupied molecular orbital (HOMO), lowest occupied molecular orbital, dipole moment, energy gap and other parameters were used to evaluate the inhibition efficiency. Performance of the protonated state (TMP++) was better than the ground state of TMP. Total electron density and FUKUI function were used to demonstration the sites of adsorption centers.

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Acknowledgements

Authors would like to thank College of Engineering in the University of Diyala for continues support and facilities.

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Authors and Affiliations

  1. Department of Medical Laboratory, College of Health and Medical Technologies, Gilgamesh Ahliya University, Baghdad, Iraq

    Noor Ali Khudhair

  2. Department of Dentistry, Kut University College, Kut, Wasit, 52001, Iraq

    Mustafa M. Kadhim

  3. College of Medical Technology, The Islamic University, Najaf, Iraq

    Mustafa M. Kadhim

  4. Department of Chemical Engineering, College of Engineering, University of Diyala, Diyala, Iraq

    Anees A. Khadom

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  1. Noor Ali Khudhair
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Correspondence to Anees A. Khadom.

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Khudhair, N.A., Kadhim, M.M. & Khadom, A.A. Effect of Trimethoprim Drug Dose on Corrosion Behavior of Stainless Steel in Simulated Human Body Environment: Experimental and Theoretical Investigations. J Bio Tribo Corros 7, 124 (2021). https://doi.org/10.1007/s40735-021-00559-8

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