Abstract
Purpose
To evaluate the prevalence of dental caries and dental developmental defects (DDD) in childhood cancer survivors (CCS) and identify disease and treatment-related risk factors.
Methods
CCS aged up to 21 years, diagnosed with a malignancy before the age of 10 years and in remission for at least one year were included. Data were collected from patients’ medical records and through a clinical examination where presence of dental caries and prevalence of DDD were recorded. Fisher’s exact test was used to assess possible correlations and multivariate regression analysis to determine risk factors for defect development.
Results
Seventy CCS with a mean chronological age of 11.2 years at the time of examination, mean age at cancer diagnosis of 4.17 years, and a mean post-treatment follow-up time of 5.48 years were included. Mean DMFT/dmft was 1.31, with 29% of survivors presenting with at least one carious lesion. Younger patients on the day of examination and patients treated with higher radiation dose, showed significantly higher prevalence of dental caries. The prevalence of DDD was 59%, with demarcated opacities being the defect most commonly observed (40%). Age at dental examination, diagnosis, age at diagnosis, and time that have elapsed since the end of treatment were the factors significantly affecting its prevalence. Regression analysis revealed that age at examination was the only factor significantly associated with the presence of coronal defects.
Conclusion
A great number of CCS presented with at least one carious lesion or a DDD, with the prevalence being significantly associated with various disease-specific characteristics, but age at dental examination the only significant predictor.
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Availability of data and materials
The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Change history
13 May 2023
A Correction to this paper has been published: https://doi.org/10.1007/s40368-023-00802-5
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All authors contributed to the study conception and design. KK conceived the idea. Material preparation and data collection was performed by KS. AK assisted sample selection and AP led the writing. The first draft of the manuscript was written KS and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
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Seremidi, K., Kavvadia, K., Kattamis, A. et al. Dental caries and dental developmental defects as adverse effects of antineoplastic treatment in childhood cancer survivors. Eur Arch Paediatr Dent 24, 357–365 (2023). https://doi.org/10.1007/s40368-023-00789-z
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DOI: https://doi.org/10.1007/s40368-023-00789-z