Skip to main content

Advertisement

SpringerLink
Log in

Oral and dental late effects in survivors of childhood cancer: a Children’s Oncology Group report

  • Review Article
  • Published:
Supportive Care in Cancer Aims and scope Submit manuscript

Abstract

Purpose

Multi-modality therapy has resulted in improved survival for childhood malignancies. The Children’s Oncology Group Long-Term Follow-Up Guidelines for Survivors of Childhood, Adolescent, and Young Adult Cancers provide practitioners with exposure- and risk-based recommendations for the surveillance and management of asymptomatic survivors who are at least 2 years from completion of therapy. This review outlines the pathophysiology and risks for oral and dental late effects in pediatric cancer survivors and the rationale for oral and dental screening recommended by the Children’s Oncology Group.

Methods

An English literature search for oral and dental complications of childhood cancer treatment was undertaken via MEDLINE and encompassed January 1975 to January 2013. Proposed guideline content based on the literature review was approved by a multi-disciplinary panel of survivorship experts and scored according to a modified version of the National Comprehensive Cancer Network “Categories of Consensus” system.

Results

The Children’s Oncology Group oral-dental panel selected 85 relevant citations. Childhood cancer therapy may impact tooth development, salivary function, craniofacial development, and temporomandibular joint function placing some childhood cancer survivors at an increased risk for poor oral and dental health. Additionally, head and neck radiation and hematopoietic stem cell transplantation increase the risk of subsequent malignant neoplasms in the oral cavity. Survivors require routine dental care to evaluate for potential side effects and initiate early treatment.

Conclusions

Certain childhood cancer survivors are at an increased risk for poor oral and dental health. Early identification of oral and dental morbidity and early interventions can optimize health and quality of life.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Howlader N, Noone AM, Krapcho M, Neyman N, Aminou R, Waldron W, Altekruse SF, Kosary CL, Ruhl J, Tatalovich Z, Cho H, Mariotto A, Eisner MP, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds) (2012) SEER Cancer Statistics Review, 1975–2009 (Vintage 2009 Populations). National Cancer Institute. http://seer.cancer.gov/csr/1975_2009_pops09/. Accessed 15 September 2012

  2. Oeffinger KC, Mertens AC, Sklar CA, Kawashima T, Hudson MM, Meadows AT, Friedman DL, Marina N, Hobbie W, Kadan-Lottick NS, Schwartz CL, Leisenring W, Robison LL, Childhood Cancer Survivor Study (2006) Chronic health conditions in adult survivors of childhood cancer. N Engl J Med 355:1572–1582

    Article  CAS  PubMed  Google Scholar 

  3. Armenian SH, Sun CL, Kawashima T, Arora M, Leisenring W, Sklar CA, Baker KS, Francisco L, Teh JB, Mills G, Wong FL, Rosenthal J, Diller LR, Hudson MM, Oeffinger KC, Forman SJ, Robison LL, Bhatia S (2011) Long-term health-related outcomes in survivors of childhood cancer treated with HSCT versus conventional therapy: a report from the Bone Marrow Transplant Survivor Study (BMTSS) and Childhood Cancer Survivor Study (CCSS). Blood 118:1413–1420

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  4. Blaauwbroek R, Groenier KH, Kamps WA, Meyboom-de Jong B, Postma A (2007) Late effects in adult survivors of childhood cancer: the need for life-long follow-up. Ann Oncol 18:1898–1902

    Article  CAS  PubMed  Google Scholar 

  5. Casagranda L, Trombert-Paviot B, Faure-Conter C, Bertrand Y, Plantaz D, Berger C (2013) Self-reported and record-collected late effects in long-term survivors of childhood cancer: a population-based cohort study of the Childhood Cancer Registry of the Rhone-Alpes Region (ARCERRA). Pediatr Hematol Oncol 30:195–207

    Article  PubMed  Google Scholar 

  6. Geenen MM, Cardous-Ubbink MC, Kremer LC, van den Bos C, van der Pal HJ, Heinen RC, Jaspers MW, Koning CC, Oldenburger F, Langeveld NE, Hart AA, Bakker PJ, Caron HN, van Leeuwen FE (2007) Medical assessment of adverse health outcomes in long-term survivors of childhood cancer. JAMA 297:2705–2715

    Article  CAS  PubMed  Google Scholar 

  7. Landier W, Bhatia S, Eshelman DA, Forte KJ, Sweeney T, Hester AL, Darling J, Armstrong FD, Blatt J, Constine LS, Freeman CR, Friedman DL, Green DM, Marina N, Meadows AT, Neglia JP, Oeffinger KC, Robison LL, Ruccione KS, Sklar CA, Hudson MM (2004) Development of risk-based guidelines for pediatric cancer survivors: the children’s oncology group long-term follow-up guidelines from the children’s oncology group late effects committee and nursing discipline. J Clin Oncol 22:4979–4990

    Article  PubMed  Google Scholar 

  8. Children’s Oncology Group (2008) Long-term follow-up guidelines for survivors of childhood, adolescent, and young adult cancers: version 3.0. Children’s oncology group. http://www.survivorshipguidelines.org/pdf/LTFUGuidelines.pdf. Accessed 31 August 2012

  9. Winn RJ, Botnick WZ (1997) The NCCN guideline program: a conceptual framework. Oncology (Williston Park) 11:25–32

    CAS  Google Scholar 

  10. Bei M (2009) Molecular genetics of tooth development. Curr Opin Genet Dev 19:504–510

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  11. ADA Division of Communication, Journal of the American Dental Association, ADA Council on Scientific Affairs (2005) For the dental patient. Tooth eruption: the primary teeth. J Am Dent Assoc 136(11):1619

    Article  Google Scholar 

  12. Goho C (1993) Chemoradiation therapy: effect on dental development. Pediatr Dent 15:6–12

    CAS  PubMed  Google Scholar 

  13. Cubukcu CE, Sevinir B, Ercan I (2012) Disturbed dental development of permanent teeth in children with solid tumors and lymphomas. Pediatr Blood Cancer 58:80–84

    Article  PubMed  Google Scholar 

  14. Kreczi A, Proff P, Reicheneder C, Faltermeier A (2011) Effects of hypodontia on craniofacial structures and mandibular growth pattern. Head Face Med 7:23

    Article  PubMed Central  PubMed  Google Scholar 

  15. Suri S, Ross RB, Tompson BD (2006) Mandibular morphology and growth with and without hypodontia in subjects with Pierre Robin sequence. Am J Orthod Dentofacial Orthop 130:37–46

    Article  PubMed  Google Scholar 

  16. Kaste SC, Hopkins KP, Bowman LC (1995) Dental abnormalities in long-term survivors of head and neck rhabdomyosarcoma. Med Pediatr Oncol 25:96–101

    Article  CAS  PubMed  Google Scholar 

  17. Kaste SC, Hopkins KP, Bowman LC, Santana VM (1998) Dental abnormalities in children treated for neuroblastoma. Med Pediatr Oncol 30:22–27

    Article  CAS  PubMed  Google Scholar 

  18. Kaste SC, Hopkins KP, Jones D, Crom D, Greenwald CA, Santana VM (1997) Dental abnormalities in children treated for acute lymphoblastic leukemia. Leukemia 11:792–796

    Article  CAS  PubMed  Google Scholar 

  19. Kaste SC, Goodman P, Leisenring W, Stovall M, Hayashi RJ, Yeazel M, Beiraghi S, Hudson MM, Sklar CA, Robison LL, Baker KS (2009) Impact of radiation and chemotherapy on risk of dental abnormalities: a report from the Childhood Cancer Survivor Study. Cancer 115:5817–5827

    Article  PubMed Central  PubMed  Google Scholar 

  20. Sonis AL, Tarbell N, Valachovic RW, Gelber R, Schwenn M, Sallan S (1990) Dentofacial development in long-term survivors of acute lymphoblastic leukemia. A comparison of three treatment modalities. Cancer 66:2645–2652

    Article  CAS  PubMed  Google Scholar 

  21. Hsieh SG, Hibbert S, Shaw P, Ahern V, Arora M (2011) Association of cyclophosphamide use with dental developmental defects and salivary gland dysfunction in recipients of childhood antineoplastic therapy. Cancer 117:2219–2227

    Article  CAS  PubMed  Google Scholar 

  22. Hutton A, Bradwell M, English M, Chapple I (2010) The oral health needs of children after treatment for a solid tumour or lymphoma. Int J Paediatr Dent 20:15–23

    Article  PubMed  Google Scholar 

  23. Holtta P, Alaluusua S, Saarinen-Pihkala UM, Peltola J, Hovi L (2005) Agenesis and microdontia of permanent teeth as late adverse effects after stem cell transplantation in young children. Cancer 103:181–190

    Article  PubMed  Google Scholar 

  24. Holtta P, Alaluusua S, Saarinen-Pihkala UM, Wolf J, Nystrom M, Hovi L (2002) Long-term adverse effects on dentition in children with poor-risk neuroblastoma treated with high-dose chemotherapy and autologous stem cell transplantation with or without total body irradiation. Bone Marrow Transplant 29:121–127

    Article  CAS  PubMed  Google Scholar 

  25. Holtta P, Hovi L, Saarinen-Pihkala UM, Peltola J, Alaluusua S (2005) Disturbed root development of permanent teeth after pediatric stem cell transplantation. Dental root development after SCT. Cancer 103:1484–1493

    Article  PubMed  Google Scholar 

  26. van der Pas-van Voskuilen IG, Veerkamp JS, Raber-Durlacher JE, Bresters D, van Wijk AJ, Barasch A, McNeal S, Gortzak RA (2009) Long-term adverse effects of hematopoietic stem cell transplantation on dental development in children. Support Care Cancer 17:1169–1175

    Article  PubMed  Google Scholar 

  27. Vaughan MD, Rowland CC, Tong X, Srivastava DK, Hale GA, Rochester R, Kaste SC (2005) Dental abnormalities after pediatric bone marrow transplantation. Bone Marrow Transplant 36:725–729

    Article  CAS  PubMed  Google Scholar 

  28. Duggal MS (2003) Root surface areas in long-term survivors of childhood cancer. Oral Oncol 39:178–183

    Article  CAS  PubMed  Google Scholar 

  29. Nasman M, Bjork O, Soderhall S, Ringden O, Dahllof G (1994) Disturbances in the oral cavity in pediatric long-term survivors after different forms of antineoplastic therapy. Pediatr Dent 16:217–223

    CAS  PubMed  Google Scholar 

  30. Kohler B, Andreen I, Jonsson B (1988) The earlier the colonization by mutans streptococci, the higher the caries prevalence at 4 years of age. Oral Microbiol Immunol 3:14–17

    Article  CAS  PubMed  Google Scholar 

  31. Purdell-Lewis DJ, Stalman MS, Leeuw JA, Humphrey GB, Kalsbeek H (1988) Long term results of chemotherapy on the developing dentition: caries risk and developmental aspects. Community Dent Oral Epidemiol 16:68–71

    Article  CAS  PubMed  Google Scholar 

  32. Wogelius P, Dahllof G, Gorst-Rasmussen A, Sorensen HT, Rosthoj S, Poulsen S (2008) A population-based observational study of dental caries among survivors of childhood cancer. Pediatr Blood Cancer 50:1221–1226

    Article  PubMed  Google Scholar 

  33. Dahllof G, Jonsson A, Ulmner M, Huggare J (2001) Orthodontic treatment in long-term survivors after pediatric bone marrow transplantation. Am J Orthod Dentofacial Orthop 120:459–465

    Article  CAS  PubMed  Google Scholar 

  34. American Academy on Pediatric Dentistry Clinical Affairs C, American Academy on Pediatric Dentistry Council on Clinical A (2008) Guideline on dental management of pediatric patients receving chemotherapy, hematopoietic cell transplantation, and/or radiation. Pediatr Dent 30:219–225

    Google Scholar 

  35. Jensen SB, Pedersen AM, Vissink A, Andersen E, Brown CG, Davies AN, Dutilh J, Fulton JS, Jankovic L, Lopes NN, Mello AL, Muniz LV, Murdoch-Kinch CA, Nair RG, Napenas JJ, Nogueira-Rodrigues A, Saunders D, Stirling B, von Bultzingslowen I, Weikel DS, Elting LS, Spijkervet FK, Brennan MT, Salivary Gland Hypofunction/Xerostomia Section, Oral Care Study Group, Multinational Association of Supportive Care in Cancer (MASCC)/International Society of Oral Oncology (ISOO) (2010) A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: prevalence, severity and impact on quality of life. Support Care Cancer 18(8):1039–1060

    Article  CAS  PubMed  Google Scholar 

  36. Garming Legert K, Remberger M, Ringden O, Heimdahl A, Dahllof G (2012) Salivary secretion in children after fractionated or single-dose TBI. Bone Marrow Transplant 47:404–410

    Article  CAS  PubMed  Google Scholar 

  37. Paulino AC, Simon JH, Zhen W, Wen BC (2000) Long-term effects in children treated with radiotherapy for head and neck rhabdomyosarcoma. Int J Radiat Oncol Biol Phys 48:1489–1495

    Article  CAS  PubMed  Google Scholar 

  38. Dahllof G (2008) Oral and dental late effects after pediatric stem cell transplantation. Biol Blood Marrow Transpl 14:81–83

    Article  Google Scholar 

  39. Guchelaar HJ, Vermes A, Meerwaldt JH (1997) Radiation-induced xerostomia: pathophysiology, clinical course and supportive treatment. Support Care Cancer 5:281–288

    Article  CAS  PubMed  Google Scholar 

  40. Selo N, Bolling T, Ernst I, Pape H, Martini C, Rube C, Timmermann B, Fischedick K, Kortmann RD, Gerss J, Koch R, Willich N (2010) Acute toxicity profile of radiotherapy in 690 children and adolescents: RiSK data. Radiother Oncol 97:119–126

    Article  PubMed  Google Scholar 

  41. Deasy JO, Moiseenko V, Marks L, Chao KS, Nam J, Eisbruch A (2010) Radiotherapy dose-volume effects on salivary gland function. Int J Radiat Oncol Biol Phys 76:S58–S63

    Article  PubMed  Google Scholar 

  42. Kam MK, Leung SF, Zee B, Chau RM, Suen JJ, Mo F, Lai M, Ho R, Cheung KY, Yu BK, Chiu SK, Choi PH, Teo PM, Kwan WH, Chan AT (2007) Prospective randomized study of intensity-modulated radiotherapy on salivary gland function in early-stage nasopharyngeal carcinoma patients. J Clin Oncol 25:4873–4879

    Article  PubMed  Google Scholar 

  43. Treister NS, Woo SB, O’Holleran EW, Lehmann LE, Parsons SK, Guinan EC (2005) Oral chronic graft-versus-host disease in pediatric patients after hematopoietic stem cell transplantation. Biol Blood Marrow Transpl 11:721–731

    Article  Google Scholar 

  44. Imanguli MM, Atkinson JC, Mitchell SA, Avila DN, Bishop RJ, Cowen EW, Datiles MB, Hakim FT, Kleiner DE, Krumlauf MC, Pavletic SZ (2010) Salivary gland involvement in chronic graft-versus-host disease: prevalence, clinical significance, and recommendations for evaluation. Biol Blood Marrow Transpl 16:1362–1369

    Article  Google Scholar 

  45. Dahllof G, Wondimu B, Barr-Agholme M, Garming-Legert K, Remberger M, Ringden O (2011) Xerostomia in children and adolescents after stem cell transplantation conditioned with total body irradiation or busulfan. Oral Oncol 47:915–919

    Article  PubMed  Google Scholar 

  46. Garming-Legert K, Remberger M, Ringden O, Hassan M, Dahllof G (2011) Long-term salivary function after conditioning with busulfan, fractionated or single-dose TBI. Oral Dis 17:670–676

    Article  CAS  PubMed  Google Scholar 

  47. Jensen SB, Pedersen AM, Vissink A, Andersen E, Brown CG, Davies AN, Dutilh J, Fulton JS, Jankovic L, Lopes NN, Mello AL, Muniz LV, Murdoch-Kinch CA, Nair RG, Napenas JJ, Nogueira-Rodrigues A, Saunders D, Stirling B, von Bultzingslowen I, Weikel DS, Elting LS, Spijkervet FK, Brennan MT, Salivary Gland Hypofunction/Xerostomia Section, Oral Care Study Group, Multinational Association of Supportive Care in Cancer (MASCC)/International Society of Oral Oncology (ISOO) (2010) A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: management strategies and economic impact. Support Care Cancer 18(8):1061–1079

    Article  CAS  PubMed  Google Scholar 

  48. Denys D, Kaste SC, Kun LE, Chaudhary MA, Bowman LC, Robbins KT (1998) The effects of radiation on craniofacial skeletal growth: a quantitative study. Int J Pediatr Otorhinolaryngol 45:7–13

    Article  CAS  PubMed  Google Scholar 

  49. Raney RB, Asmar L, Vassilopoulou-Sellin R, Klein MJ, Donaldson SS, Green J, Heyn R, Wharam M, Glicksman AS, Gehan EA, Anderson J, Maurer HM (1999) Late complications of therapy in 213 children with localized, nonorbital soft-tissue sarcoma of the head and neck: a descriptive report from the Intergroup Rhabdomyosarcoma Studies (IRS)-II and -III. IRS Group of the Children’s Cancer Group and the Pediatric Oncology Group. Med Pediatr Oncol 33:362–371

    Article  CAS  PubMed  Google Scholar 

  50. Gevorgyan A, La Scala GC, Neligan PC, Pang CY, Forrest CR (2007) Radiation-induced craniofacial bone growth disturbances. J Craniofac Surg 18:1001–1007

    Article  PubMed  Google Scholar 

  51. Rohner D, Guijarro-Martinez R, Bucher P, Hammer B (2013) Importance of patient-specific intraoperative guides in complex maxillofacial reconstruction. J Craniomaxillofac Surg 41:382–390

    Article  PubMed  Google Scholar 

  52. Daoud J, Toumi N, Bouaziz M, Ghorbel A, Jlidi R, Drira MM, Frikha M (2003) Nasopharyngeal carcinoma in childhood and adolescence: analysis of a series of 32 patients treated with combined chemotherapy and radiotherapy. Eur J Cancer 39:2349–2354

    Article  CAS  PubMed  Google Scholar 

  53. Kupeli S, Varan A, Ozyar E, Atahan IL, Yalcin B, Kutluk T, Akyuz C, Buyukpamukcu M (2006) Treatment results of 84 patients with nasopharyngeal carcinoma in childhood. Pediatr Blood Cancer 46:454–458

    Article  PubMed  Google Scholar 

  54. Zubizarreta PA, D’Antonio G, Raslawski E, Gallo G, Preciado MV, Casak SJ, Scopinaro M, Morales G, Sackmann-Muriel F (2000) Nasopharyngeal carcinoma in childhood and adolescence: a single-institution experience with combined therapy. Cancer 89:690–695

    Article  CAS  PubMed  Google Scholar 

  55. Otmani N (2007) Oral and maxillofacial side effects of radiation therapy on children. J Can Dent Assoc 73:257–261

    PubMed  Google Scholar 

  56. Goldstein M, Maxymiw WG, Cummings BJ, Wood RE (1999) The effects of antitumor irradiation on mandibular opening and mobility: a prospective study of 58 patients. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 88:365–373

    Article  CAS  PubMed  Google Scholar 

  57. Louise Kent M, Brennan MT, Noll JL, Fox PC, Burri SH, Hunter JC, Lockhart PB (2008) Radiation-induced trismus in head and neck cancer patients. Support Care Cancer 16:305–309

    Article  CAS  PubMed  Google Scholar 

  58. Teguh DN, Levendag PC, Voet P, van der Est H, Noever I, de Kruijf W, van Rooij P, Schmitz PI, Heijmen BJ (2008) Trismus in patients with oropharyngeal cancer: relationship with dose in structures of mastication apparatus. Head Neck 30:622–630

    Article  PubMed  Google Scholar 

  59. Johnson J, van As-Brooks CJ, Fagerberg-Mohlin B, Finizia C (2010) Trismus in head and neck cancer patients in Sweden: incidence and risk factors. Med Sci Monit 16:CR278–CR282

    PubMed  Google Scholar 

  60. Tang Y, Shen Q, Wang Y, Lu K, Wang Y, Peng Y (2011) A randomized prospective study of rehabilitation therapy in the treatment of radiation-induced dysphagia and trismus. Strahlenther Onkol 187:39–44

    Article  CAS  PubMed  Google Scholar 

  61. Ferri A, Bianchi B, Leporati M, Sesenna E (2011) Anterolateral thigh free flap for trismus release in pediatric oncology patients. Br J Oral Maxillofac Surg 49:e58–e60

    Article  CAS  PubMed  Google Scholar 

  62. Chen YY, Zhao C, Wang J, Ma HL, Lai SZ, Liu Y, Han F, Lu LX, Bao Y, Chen M (2011) Intensity-modulated radiation therapy reduces radiation-induced trismus in patients with nasopharyngeal carcinoma: a prospective study with >5 years of follow-up. Cancer 117:2910–2916

    Article  PubMed  Google Scholar 

  63. Nabil S, Samman N (2012) Risk factors for osteoradionecrosis after head and neck radiation: a systematic review. Oral Surg Oral Med Oral Pathol Oral Radiol 113:54–69

    Article  PubMed  Google Scholar 

  64. Gaisford J, Rueckert F (1956) Osteoradionecrosis of the mandible. Plast Reconstr Surg 18(1946):436–447

    Article  CAS  Google Scholar 

  65. Wahl MJ (2006) Osteoradionecrosis prevention myths. Int J Radiat Oncol Biol Phys 64:661–669

    Article  PubMed  Google Scholar 

  66. Curi MM, Dib LL (1997) Osteoradionecrosis of the jaws: a retrospective study of the background factors and treatment in 104 cases. J Oral Maxillofac Surg 55:540–544, discussion 545–546

    Article  CAS  PubMed  Google Scholar 

  67. Chrcanovic BR, Reher P, Sousa AA, Harris M (2010) Osteoradionecrosis of the jaws–a current overview–part 1: physiopathology and risk and predisposing factors. Oral Maxillofac Surg 14:3–16

    Article  PubMed  Google Scholar 

  68. Tsai CJ, Hofstede TM, Sturgis EM, Garden AS, Lindberg ME, Wei Q, Tucker SL, Dong L (2013) Osteoradionecrosis and radiation dose to the mandible in patients with oropharyngeal cancer. Int J Radiat Oncol Biol Phys 85:415–420

    Article  PubMed  Google Scholar 

  69. Ashamalla HL, Thom SR, Goldwein JW (1996) Hyperbaric oxygen therapy for the treatment of radiation-induced sequelae in children. The University of Pennsylvania experience. Cancer 77:2407–2412

    Article  CAS  PubMed  Google Scholar 

  70. Schuurhuis JM, Stokman MA, Roodenburg JL, Reintsema H, Langendijk JA, Vissink A, Spijkervet FK (2011) Efficacy of routine pre-radiation dental screening and dental follow-up in head and neck oncology patients on intermediate and late radiation effects. A retrospective evaluation. Radiother Oncol 101:403–409

    Article  PubMed  Google Scholar 

  71. Jereczek-Fossa BA, Orecchia R (2002) Radiotherapy-induced mandibular bone complications. Cancer Treat Rev 28:65–74

    Article  PubMed  Google Scholar 

  72. Dische S, Saunders M, Barrett A, Harvey A, Gibson D, Parmar M (1997) A randomised multicentre trial of CHART versus conventional radiotherapy in head and neck cancer. Radiother Oncol 44:123–136

    Article  CAS  PubMed  Google Scholar 

  73. Niewald M, Barbie O, Schnabel K, Engel M, Schedler M, Nieder C, Berberich W (1996) Risk factors and dose-effect relationship for osteoradionecrosis after hyperfractionated and conventionally fractionated radiotherapy for oral cancer. Br J Radiol 69:847–851

    Article  CAS  PubMed  Google Scholar 

  74. Chuang SK (2012) Limited evidence to demonstrate that the use of hyperbaric oxygen (HBO) therapy reduces the incidence of osteoradionecrosis in irradiated patients requiring tooth extraction. J Evid Based Dent Pract 12:248–250

    Article  PubMed  Google Scholar 

  75. David LA, Sandor GK, Evans AW, Brown DH (2001) Hyperbaric oxygen therapy and mandibular osteoradionecrosis: a retrospective study and analysis of treatment outcomes. J Can Dent Assoc 67:384

    CAS  PubMed  Google Scholar 

  76. Mounsey RA, Brown DH, O’Dwyer TP, Gullane PJ, Koch GH (1993) Role of hyperbaric oxygen therapy in the management of mandibular osteoradionecrosis. Laryngoscope 103:605–608

    Article  CAS  PubMed  Google Scholar 

  77. Hirsch DL, Bell RB, Dierks EJ, Potter JK, Potter BE (2008) Analysis of microvascular free flaps for reconstruction of advanced mandibular osteoradionecrosis: a retrospective cohort study. J Oral Maxillofac Surg 66:2545–2556

    Article  PubMed  Google Scholar 

  78. Meier JK, Wolff D, Pavletic S, Greinix H, Gosau M, Bertz H, Lee SJ, Lawitschka A, Elad S, International Consensus Conference on Clinical Practice in cGVHD (2011) Oral chronic graft-versus-host disease: report from the International Consensus Conference on clinical practice in cGVHD. Clin Oral Investig 15(2):127–139

    Article  PubMed  Google Scholar 

  79. Flowers ME, Parker PM, Johnston LJ, Matos AV, Storer B, Bensinger WI, Storb R, Appelbaum FR, Forman SJ, Blume KG, Martin PJ (2002) Comparison of chronic graft-versus-host disease after transplantation of peripheral blood stem cells versus bone marrow in allogeneic recipients: long-term follow-up of a randomized trial. Blood 100:415–419

    Article  CAS  PubMed  Google Scholar 

  80. Nicolatou-Galitis O, Kitra V, Van Vliet-Constantinidou C, Peristeri J, Goussetis E, Petropoulos D, Grafakos S (2001) The oral manifestations of chronic graft-versus-host disease (cGVHD) in paediatric allogeneic bone marrow transplant recipients. J Oral Pathol Med 30:148–153

    Article  CAS  PubMed  Google Scholar 

  81. Mays JW, Fassil H, Edwards DA, Pavletic SZ, Bassim CW (2013) Oral chronic graft-versus-host disease: current pathogenesis, therapy, and research. Oral Dis 19:327–346

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  82. Filipovich AH, Weisdorf D, Pavletic S, Socie G, Wingard JR, Lee SJ, Martin P, Chien J, Przepiorka D, Couriel D, Cowen EW, Dinndorf P, Farrell A, Hartzman R, Henslee-Downey J, Jacobsohn D, McDonald G, Mittleman B, Rizzo JD, Robinson M, Schubert M, Schultz K, Shulman H, Turner M, Vogelsang G, Flowers MED (2005) National institutes of health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. Diagnosis and staging working group report. Biol Blood Marrow Transplant 11:945–956

    Article  PubMed  Google Scholar 

  83. Demarosi F, Lodi G, Carrassi A, Soligo D, Sardella A (2005) Oral malignancies following HSCT: graft versus host disease and other risk factors. Oral Oncol 41:865–877

    Article  PubMed  Google Scholar 

  84. Baird K, Cooke K, Schultz KR (2010) Chronic graft-versus-host disease (GVHD) in children. Pediatr Clin North Am 57:297–322

    Article  PubMed Central  PubMed  Google Scholar 

  85. Curtis RE, Rowlings PA, Deeg HJ, Shriner DA, Socie G, Travis LB, Horowitz MM, Witherspoon RP, Hoover RN, Sobocinski KA, Fraumeni JF Jr, Boice JD Jr (1997) Solid cancers after bone marrow transplantation. N Engl J Med 336:897–904

    Article  CAS  PubMed  Google Scholar 

  86. Socie G, Curtis RE, Deeg HJ, Sobocinski KA, Filipovich AH, Travis LB, Sullivan KM, Rowlings PA, Kingma DW, Banks PM, Travis WD, Witherspoon RP, Sanders J, Jaffe ES, Horowitz MM (2000) New malignant diseases after allogeneic marrow transplantation for childhood acute leukemia. J Clin Oncol 18:348–357

    CAS  PubMed  Google Scholar 

  87. Bassal M, Mertens AC, Taylor L, Neglia JP, Greffe BS, Hammond S, Ronckers CM, Friedman DL, Stovall M, Yasui YY, Robison LL, Meadows AT, Kadan-Lottick NS (2006) Risk of selected subsequent carcinomas in survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. J Clin Oncol 24:476–483

    Article  PubMed  Google Scholar 

  88. Inskip PD, Curtis RE (2007) New malignancies following childhood cancer in the United States, 1973–2002. Int J Cancer 121:2233–2240

    Article  CAS  PubMed  Google Scholar 

  89. Mawardi H, Elad S, Correa ME, Stevenson K, Woo SB, Almazrooa S, Haddad R, Antin JH, Soiffer R, Treister N (2011) Oral epithelial dysplasia and squamous cell carcinoma following allogeneic hematopoietic stem cell transplantation: clinical presentation and treatment outcomes. Bone Marrow Transplant 46:884–891

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  90. Rizzo JD, Curtis RE, Socie G, Sobocinski KA, Gilbert E, Landgren O, Travis LB, Travis WD, Flowers ME, Friedman DL, Horowitz MM, Wingard JR, Deeg HJ (2009) Solid cancers after allogeneic hematopoietic cell transplantation. Blood 113:1175–1183

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  91. Bhatia S, Louie AD, Bhatia R, O’Donnell MR, Fung H, Kashyap A, Krishnan A, Molina A, Nademanee A, Niland JC, Parker PA, Snyder DS, Spielberger R, Stein A, Forman SJ (2001) Solid cancers after bone marrow transplantation. J Clin Oncol 19:464–471

    CAS  PubMed  Google Scholar 

  92. Baker KS, DeFor TE, Burns LJ, Ramsay NK, Neglia JP, Robison LL (2003) New malignancies after blood or marrow stem-cell transplantation in children and adults: incidence and risk factors. J Clin Oncol 21:1352–1358

    Article  PubMed  Google Scholar 

  93. Treister N, Duncan C, Cutler C, Lehmann L (2012) How we treat oral chronic graft-versus-host disease. Blood 120:3407–3418

    Article  CAS  PubMed  Google Scholar 

  94. Hudson MM, Hester A (2008) Health link: reducing the risk of second cancers, version 3.0. Chidren’s Oncology Group. http://www.survivorshipguidelines.org/pdf/ReducingSecondCancerRisk.pdf. Accessed 15 September 2012

  95. Lockhart PB, Brennan MT, Sasser HC, Fox PC, Paster BJ, Bahrani-Mougeot FK (2008) Bacteremia associated with toothbrushing and dental extraction. Circulation 117:3118–3125

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  96. Wilson W, Taubert KA, Gewitz M, Lockhart PB, Baddour LM, Levison M, Bolger A, Cabell CH, Takahashi M, Baltimore RS, Newburger JW, Strom BL, Tani LY, Gerber M, Bonow RO, Pallasch T, Shulman ST, Rowley AH, Burns JC, Ferrieri P, Gardner T, Goff D, Durack DT, American Heart Association (2008) Prevention of infective endocarditis: guidelines from the American Heart Association: a guideline from the American Heart Association Rheumatic Fever, Endocarditis and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young, and the Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and the Quality of Care and Outcomes Research Interdisciplinary Working Group. J Am Dent Assoc 139(Suppl):3S–24S

    Article  PubMed  Google Scholar 

  97. American Academy on Pediatric Dentistry Clinical Affairs Committee, American Academy on Pediatric Dentistry Council on Clinical Affairs (2008) Guideline on antibiotic prophylaxis for dental patients at risk for infection. Pediatr Dent 30(7 Suppl):215–218

    Google Scholar 

  98. Tate AR, Norris CK, Minniti CP (2006) Antibiotic prophylaxis for children with sickle cell disease: a survey of pediatric dentistry residency program directors and pediatric hematologists. Pediatr Dent 28:332–335

    PubMed  Google Scholar 

  99. Price VE, Blanchette VS, Ford-Jones EL (2007) The prevention and management of infections in children with asplenia or hyposplenia. Infect Dis Clin North Am 21:697–710, viii-ix

    Article  PubMed  Google Scholar 

  100. Watters W 3rd, Rethman MP, Hanson NB, Abt E, Anderson PA, Carroll KC, Futrell HC, Garvin K, Glenn SO, Hellstein J, Hewlett A, Kolessar D, Moucha C, O’Donnell RJ, O’Toole JE, Osmon DR, Evans RP, Rinella A, Steinberg MJ, Goldberg M, Ristic H, Boyer K, Sluka P, Martin WR 3rd, Cummins DS, Song S, Woznica A, Gross L (2013) Prevention of orthopaedic implant infection in patients undergoing dental procedures. J Am Acad Orthop Surg 21:180–189

    Article  PubMed  Google Scholar 

  101. (2002) For the dental patient: oral care for cancer patients. J Am Dent Assoc 133 (7):1014.

  102. Casillas J, Castellino SM, Hudson MM, Mertens AC, Lima IS, Liu Q, Zeltzer LK, Yasui Y, Robison LL, Oeffinger KC (2011) Impact of insurance type on survivor-focused and general preventive health care utilization in adult survivors of childhood cancer: the Childhood Cancer Survivor Study (CCSS). Cancer 117:1966–1975

    Article  PubMed Central  PubMed  Google Scholar 

Download references

Acknowledgments

This research was supported by the Children’s Oncology Group Chair’s Grant U10 CA098543.

Disclosures

Dr. Migliorati is a consultant for Amgen Inc. and Colgate.

Author information

Authors and Affiliations

  1. Division of Pediatric Hematology/Oncology/Stem Cell Transplantation, Stanford University, 1000 Welch Rd, Suite 300, Palo Alto, CA, 94304, USA

    Karen E. Effinger

  2. Department of Diagnostic Sciences and Oral Medicine, University of Tennessee Health Science Center, 875 Union Ave. Suite N231, Memphis, TN, 38163, USA

    Cesar A. Migliorati

  3. Departments of Oncology and Epidemiology and Cancer Control, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Mailstop 735, Memphis, TN, 38105, USA

    Melissa M. Hudson

  4. Department of Radiation Oncology, Indiana University School of Medicine, 535 Barnhill Drive, RT 041, Indianapolis, IN, 46202, USA

    Kevin P. McMullen

  5. Department of Radiological Sciences, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, MSN 220, Memphis, TN, 38105, USA

    Sue C. Kaste

  6. Division of Pediatric Oncology, John Hopkins School of Medicine, Bloomberg Children’s Center, Room 11368, 1800 Orleans St, Baltimore, MD, 21287, USA

    Kathy Ruble

  7. Section of Paediatric Oncology, Division of Oncology, University of Calgary, 2888 Shaganappi Trail NW, Calgary, T3B 6A8, AB, Canada

    Gregory M. T. Guilcher

  8. Division of Pediatric Hematology/Oncology, University of California Los Angeles, A2-410 MDCC, 10833 Le Conte Avenue, Los Angeles, CA, 90095, USA

    Ami J. Shah

  9. Departments of Pediatrics, Section of Hematology/Oncology, and Epidemiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157, USA

    Sharon M. Castellino

Authors
  1. Karen E. Effinger
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Cesar A. Migliorati
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Melissa M. Hudson
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Kevin P. McMullen
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Sue C. Kaste
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Kathy Ruble
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Gregory M. T. Guilcher
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Ami J. Shah
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Sharon M. Castellino
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Karen E. Effinger.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Effinger, K.E., Migliorati, C.A., Hudson, M.M. et al. Oral and dental late effects in survivors of childhood cancer: a Children’s Oncology Group report. Support Care Cancer 22, 2009–2019 (2014). https://doi.org/10.1007/s00520-014-2260-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00520-014-2260-x

Keywords

Search

Navigation