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Long-Term Effect of Anticancer Therapy on Dentition in Childhood Cancer Survivors: An Observational, Cross-Sectional Study

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Indian Journal of Pediatrics Aims and scope Submit manuscript

Abstract

Objectives

To evaluate the presence of developmental dental anomalies, like microdontia, hypodontia, abnormally shaped teeth (AST), and developmental defects of enamel (DDE) in childhood cancer survivors and compare it with the healthy controls.

Methods

This cross-sectional analytical study was conducted in 2 groups: childhood cancer survivors (CCS) group including children (> 12 y, m/f) who had undergone anticancer therapy (ACT) before 8 y of age and healthy control group (> 12 y, m/f) without any systemic disease. Pearson chi-square test was used to analyze the difference between the CCS group and the control group for microdontia, hypodontia, AST, DDE and for intragroup analysis in CCS group. Odds ratio was also calculated.

Results

A total of 120 and 121 children were included in CCS and control group, respectively. The prevalence of microdontia, hypodontia, abnormally shaped teeth, and DDE was 17.5% (21), 5% (6), 8.33% (10), and 37.5% (45), respectively in CCS group. It was 8.2% (10), 2.5% (3), 1.65% (2), and 22.3% (27), respectively in the control group. A statistically significant difference was seen in microdontia (p = 0.032), abnormally shaped teeth (p = 0.017) and DDE (p = 0.01). Higher prevalence was seen when ACT began at an early age.

Conclusion

An association between developmental dental anomalies and anticancer therapy (ACT) exists with significantly higher difference in microdontia, abnormally shaped teeth and DDE among survivors of childhood cancer as compared to healthy population. These known adverse effects of ACT on developing teeth should be considered during treatment planning of the children having cancers.

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Acknowledgements

The research team acknowledges the support received from the Patients Record Section, residents, research staff, and Faculty of Medical Oncology as well as the administration of the schools from where the controls were recruited.

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Authors and Affiliations

  1. Department of Pedodontics & Preventive Dentistry, Center for Dental Education & Research, All India Institute of Medical Sciences, 6th Floor, New Delhi, 110029, India

    Mohammad Atif, Vijay Prakash Mathur, Nitesh Tewari, Kalpana Bansal & Morankar Rahul

  2. Department of Medical Oncology, Dr B. R. A. Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, 110029, India

    Sameer Bakhshi

Authors
  1. Mohammad Atif
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  2. Vijay Prakash Mathur
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  3. Nitesh Tewari
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Contributions

MA: Concept, design, review of literature, data analysis, statistical analysis, preparation and revision of manuscript; VPM: Concept, design, data collection supervision, statistical analysis, preparation, and revision of manuscript; NT: Concept, design, review of literature, data analysis, statistical analysis, preparation and revision of manuscript; KB: Design of the study, data collection, and revision of manuscript; MR: Data filtration and check, statistical analysis, preparation and revision of manuscript; SB: Concept, design, data collection supervision, preparation and revision of manuscript; MA, VPM, NT, KB, MR, SB: Final approval of the manuscript. VPM is the guarantor for this paper.

Corresponding author

Correspondence to Vijay Prakash Mathur.

Ethics declarations

Ethical Approval

All procedures performed in the study were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Approval was taken from Institutional Ethics Committee, All India Institute of Medical Sciences. Date- 14/08/2017. NO. IECPG-148/26.04.2018, RT-10/2018.

Consent to Participate

Informed consent was obtained from all individual participants included in the study. Written informed consent was obtained from legal guardians of minors. Written informed consent was taken from adults. Verbal informed consent was obtained prior to the interview.

Consent to Publish

Patients (in case of adults) and legal guardians (in case of minors) signed informed consent regarding publishing their data and photographs.

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Atif, M., Mathur, V.P., Tewari, N. et al. Long-Term Effect of Anticancer Therapy on Dentition in Childhood Cancer Survivors: An Observational, Cross-Sectional Study. Indian J Pediatr 89, 327–332 (2022). https://doi.org/10.1007/s12098-021-03818-1

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