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A case–controlled investigation of risk factors associated with molar incisor hypomineralization (MIH) in 8–12 year-old children living in Chandigarh, India

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Abstract

Purpose

Despite mounting evidence in favour of various perinatal risk factors for occurrence of MIH, verification of these remains doubtful because of lack of documented proof. The present study was aimed at examining the putative risk factors for MIH based on hospital-maintained records assessment.

Methods

A total of 3176, 8–12 year-old children were screened for MIH using EAPD criteria (2003). Of these, risk factor analysis was carried out for 104 MIH affected and 211 non-MIH affected children with complete peri-natal medical records maintained up to 3 year post-birth. Chi-square test was used for risk factor comparison, while significance was assessed using logistic regression.

Results

Prevalence of MIH in study population was 11.72% (372/3176). Various pre-natal, natal and post-natal risk factors including intra-uterine growth retardation (6.7 vs. 1.4%); maternal anaemia (10.6 vs. 3.8%) and neonatal jaundice (29.8 vs. 14.2%) were significantly higher in the MIH group. Furthermore, pre-term birth (OR 3.01), low birth weight (OR 2.37), more than three pyrogenic episodes (OR 7.61) and consumption of Amoxicillin Clavulanate (OR 3.01) were significantly associated with higher risk of developing MIH.

Conclusions

Pre and post-natal risk factors showed a moderate to high association for occurrence of MIH although social and nutritional factors had a lesser association.

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Funding

NA (self-funded).

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Author notes

  1. A. Dhareula

    Present address: Divisional Railways Hospital, Central Railways, Pune, 411001, Maharashtra, India

Authors and Affiliations

  1. Unit of Pedodontics and Preventive Dentistry, Oral Health Sciences Centre, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India

    S. Mariam, A. Goyal, A. Dhareula, K. Gauba, S. K. Bhatia & A. Kapur

Authors
  1. S. Mariam
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  2. A. Goyal
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  3. A. Dhareula
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  4. K. Gauba
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  5. S. K. Bhatia
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Corresponding author

Correspondence to A. Dhareula.

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Ethical approval

Obtained from Institutional Ethics Committee vide letter no NK/308/MDS/8735-36.

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Obtained from parents/guardians of the examined as well as recalled children included in the study.

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Mariam, S., Goyal, A., Dhareula, A. et al. A case–controlled investigation of risk factors associated with molar incisor hypomineralization (MIH) in 8–12 year-old children living in Chandigarh, India. Eur Arch Paediatr Dent 23, 97–107 (2022). https://doi.org/10.1007/s40368-021-00665-8

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  • DOI: https://doi.org/10.1007/s40368-021-00665-8

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