Abstract
Healthy term babies undergo a physiological nadir in serum calcium levels by 24–48 hours of age. This nadir may be related to the delayed response of parathyroid and calcitonin hormones in a newborn. This nadir may drop to hypocalcemic levels in high-risk neonates including infants of diabetic mothers, preterm infants and infants with perinatal asphyxia. This early onset hypocalcemia which presents within 72 hours, requires treatment with calcium supplementation for at least 72 hours. In contrast late onset hypocalcemia usually presents after 7 days and requires long term therapy. Ionized calcium is crucial for many biochemical processes and total serum calcium is a poor substitute for the diagnosis of hypocalcemia.
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References
Oden J, Bourgeois M. Neonatal endocrinology.Indian J Pediatr 2000; 67: 217–223.
Schwartz R, Teramo KA. Effects of diabetic pregnancy on the fetus and newborn.Semin Perinatol 2000; 24: 120–135.
Salle BL, Delvin EE, Lapillonne A, Bishop NJ, Glorieux FH. Perinatal metabolism of vitamin D.Am J Clin Nutr 2000; 71 (Suppl 5): 1317S-1324S.
Marx SJ. Hyperparathyroid and hypoparathyroid disorders.N Engl J Med 2000; 343: 1863–1875.
Mimouni F, Tsang RC. Neonatal hypocalcemia: to treat or not to treat?J Am Coll Nutr 1994; 13: 408–415.
Salle BL, Delvin E, Glorieux F, David L. Human neonatal hypocalcemia.Biol Neonate 1990; 58 (Suppl 1): 22–31.
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Aggarwal, R., Upadhyay, M., Deorari, A.K. et al. Hypocalcemia in the Newborn. Indian J Pediatr 68, 973–976 (2001). https://doi.org/10.1007/BF02722599
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DOI: https://doi.org/10.1007/BF02722599