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Electrochemical Chiral Recognizing Tryptophan Enantiomers Based on Chiral Metal-Organic Framework D-MOF

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Chemical Research in Chinese Universities Aims and scope

Abstract

In this work, an electrochemical chiral sensor of a nanowire-like chiral metal-organic framework/multiwalled carbon nanotube-chitosan/glassy carbon electrode(D-MOF/MWCNTs-CS/GCE) was proposed for the enantiorecognition of L/D-tryptophan(L/D-Trp). The asymmetrical spatial structure of D-MOF provides the feasibility for the enantiorecognition of Trp enantiomers. Moreover, differential pulse voltammetry(DPV) was carried out to be the detection method and the DPV peak potential difference(ΔEp) between L-Trp and D-Trp was referred as the index of the enantiorecognition performance. Several parameters, such as mass ratios and drop-coated volume of MWCNTs-CS, drop-coated volume and concentration of D-MOF, pH and detection temperature of D-MOF/MWCNTs-CS/GCE were optimized for the largest ΔEp value. And the molecular dynamics(MD) simulation was used to elucidate the enantiorecognition mechanism. Furthermore, the proportions of D-Trp(D-Trp%) in Trp mixtures were detected in a good linear relationship with the DPV peak potentials(Ep), and the proposed electrochemical chiral sensor exhibited good reproducibility, stability and enantiorecognition ability. Additionally, the proposed electrochemical chiral sensor(D-MOF/MWCNTs-CS/GCE) has a good application prospect in the fields of biomedicine, clinical diagnosis, chemical production, pharmaceuticals safety and so on.

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Acknowledgements

This work was supported by the National Key R&D Program of China (No. 2019YFA0904104).

The authors thank Biological & Medical Engineering Core Facilities, Beijing Institute of Technology for kindly providing the laboratory facilities for testing. Moreover, the authors thank Chengdu Tianji Technology Co., Ltd. for their technical support in the construction of the molecular dynamics(MD) simulation.

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  1. These authors contributed equally to this work.

Authors and Affiliations

  1. Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing, 100081, P. R. China

    Huipeng Hou, Shanshan Tang, Wei Wang, Miao Liu, Axin Liang, Bingteng Xie, Yue Yi & Aiqin Luo

Authors
  1. Huipeng Hou
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  2. Shanshan Tang
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  3. Wei Wang
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  4. Miao Liu
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  5. Axin Liang
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  6. Bingteng Xie
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  7. Yue Yi
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  8. Aiqin Luo
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Corresponding authors

Correspondence to Yue Yi or Aiqin Luo.

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Hou, H., Tang, S., Wang, W. et al. Electrochemical Chiral Recognizing Tryptophan Enantiomers Based on Chiral Metal-Organic Framework D-MOF. Chem. Res. Chin. Univ. 39, 976–984 (2023). https://doi.org/10.1007/s40242-023-3004-6

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  • DOI: https://doi.org/10.1007/s40242-023-3004-6

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