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An electrochemical chiral sensor based on the synergy of chiral ionic liquid and 3D-NGMWCNT for tryptophan enantioselective recognition

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Abstract

A facile chiral composite (3D-NGMWCNT@(S,S)-CIL) was prepared by integrating three-dimensional N-doped graphene oxide multi-walled carbon nanotubes (3D-NGMWCNT) and chiral ionic liquid ((S,S)-CIL) via electrodeposition. SEM, XRD, XPS, and electrochemical methods were used to characterize this composite and it revealed that the integrated 3D-NGMWCNT@(S,S)-CIL composite showed excellent electrochemical performance. Therefore, a 3D-NGMWCNT@(S,S)-CIL/GCE electrochemical sensor was constructed for enantioselective recognition of Trp enantiomers. The coefficient (IL/ID) of the 3D-NGMWCNT@(S,S)-CIL/GCE chiral sensor was 2.26 by differential pulse voltammograms (DPV), revealing that the synthesized 3D-NGMWCNT@(S,S)-CIL had a higher affinity for L-Trp than D-Trp. Moreover, UV-V is spectroscopy and a water contact angle test also proved this result. The 3D-NGMWCNT@(S,S)-CIL/GCE sensor had a detection limit of 0.024 μM and 0.055 μM, and sensitivity of 62.35 μA·mM−1·cm−2 and 30.40 μA·mM−1·cm−2 for L-Trp and D-Trp, respectively, with a linear response range of 0.01 to 5 mM. In addition, the 3D-NGMWCNT@(S,S)-CIL/GCE chiral sensor showed excellent stability, and good reproducibility and was applied to detect L-Trp or D-Trp in real samples. The novel 3D-NGMWCNT@(S,S)-CIL/GCE chiral sensor provides an efficient and convenient strategy for chiral enantioselective recognition.

Graphical abstract

Schematic construction of the 3D-NGMWCNT@(S,S)-CIL/GCE chiral electrochemical sensors

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Funding

This work was supported by the Natural Science Foundation of China (21861034; 51262027); and the Natural Science Foundation of Gansu Province (18JR3RA094); the Key Research and Development Project of Gansu Province (20YF3GA022).

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Authors and Affiliations

  1. Research Center of Gansu Military and Civilian Integration Advanced Structural Materials, Key Laboratory of Eco-Environment-Related Polymer Materials, Ministry of Education of China, Key Laboratory of Polymer Materials of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, 730070, People’s Republic of China

    Nijuan Liu, Jingjing Liu, Xiaohui Niu, Jia Wang, Ruibin Guo & Zunli Mo

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  1. Nijuan Liu
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  2. Jingjing Liu
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  3. Xiaohui Niu
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  6. Zunli Mo
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Correspondence to Nijuan Liu or Zunli Mo.

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Liu, N., Liu, J., Niu, X. et al. An electrochemical chiral sensor based on the synergy of chiral ionic liquid and 3D-NGMWCNT for tryptophan enantioselective recognition. Microchim Acta 188, 163 (2021). https://doi.org/10.1007/s00604-021-04818-w

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  • DOI: https://doi.org/10.1007/s00604-021-04818-w

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