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Using Zebrafish to Model Liver Diseases-Where Do We Stand?

  • Xenopus and Zebrafish Models for Pathobiology (W Goessling and A Zorn, Section Editors)
  • Published:
Current Pathobiology Reports

Abstract

Purpose of review

The liver is the largest internal organ and performs both exocrine and endocrine function that is necessary for survival. Liver failure is among the leading causes of death and represents a major global health burden. Liver transplantation is the only effective treatment for end-stage liver diseases. Animal models advance our understanding of liver disease etiology and hold promise for the development of alternative therapies. Zebrafish has become an increasingly popular system for modeling liver diseases and complements the rodent models.

Recent findings

The zebrafish liver contains main cell types that are found in mammalian liver and exhibits similar pathogenic responses to environmental insults and genetic mutations. Zebrafish have been used to model neonatal cholestasis, cholangiopathies, alcoholic liver disease, and non-alcoholic fatty liver disease. It also provides a unique opportunity to study the plasticity of liver parenchymal cells during regeneration.

Summary

In this review, we summarize the recent work of building zebrafish models of liver diseases. We highlight how these studies have brought new knowledge of disease mechanisms. We also discuss the advantages and challenges of using zebrafish to model liver diseases.

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Acknowledgements

This work was supported by National Institutes of Health Grant R00AA020514 and a pilot award from Center for Pediatric Genomics in Cincinnati Children’s Hospital.

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  1. Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 45229, USA

    Duc-Hung Pham, Changwen Zhang & Chunyue Yin

  2. Division of Developmental Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 45229, USA

    Chunyue Yin

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  1. Duc-Hung Pham
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This article is part of the Topical Collection on Xenopus and Zebrafish Models for Pathobiology

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Pham, DH., Zhang, C. & Yin, C. Using Zebrafish to Model Liver Diseases-Where Do We Stand?. Curr Pathobiol Rep 5, 207–221 (2017). https://doi.org/10.1007/s40139-017-0141-y

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