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Zebrafish: Model for the Study of Inflammation and the Innate Immune Response to Infectious Diseases

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Current Topics in Innate Immunity II

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 946))

Abstract

The zebrafish (Danio rerio) has been extensively used in biomedical research as a model to study vertebrate development and hematopoiesis and recently, it has been adopted into varied fields including immunology. After fertilization, larvae survive with only the innate immune responses because adaptive immune system is morphologically and functionally mature only after 4–6 weeks postfertilization. This temporal separation provides a suitable system to study the vertebrate innate immune response in vivo, independently from the adaptive immune response. The transparency of early life stages allows a useful real-time visualization. Adult zebrafish which have complete (innate and adaptative) immune systems offer also advantages over other vertebrate infection models: small size, relatively rapid life cycle, ease of breeding, and a growing list of molecular tools for the study of infectious diseases. In this review, we have tried to give some examples of the potential of zebrafish as a valuable model in innate immunity and inflammation studies.

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Acknowledgments

We want to thank the funding from the project CSD2007-00002 “Aquagenomics” of the program Consolider-Ingenio 2010 from the Spanish Ministerio de Ciencia e Innovación.

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  1. Instituto de Investigaciones Marinas, CSIC, Eduardo Cabello 6, 36208, Vigo, Spain

    Beatriz Novoa & Antonio Figueras

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  1. Beatriz Novoa
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  2. Antonio Figueras
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Correspondence to Antonio Figueras .

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  1. Department Of Pathology Laboratory Of, Medicine, University Of Pennsylvania, Johnson Pavilion 410, Philadelphia, 19104, Pennsylvania, USA

    John D. Lambris

  2. Health Sciences Center, University of Louisville, Louisville, 40292, Kentucky, USA

    George Hajishengallis

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Novoa, B., Figueras, A. (2012). Zebrafish: Model for the Study of Inflammation and the Innate Immune Response to Infectious Diseases. In: Lambris, J., Hajishengallis, G. (eds) Current Topics in Innate Immunity II. Advances in Experimental Medicine and Biology, vol 946. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0106-3_15

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