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Na2EDTA: an efficient, green and reusable catalyst for the synthesis of biologically important spirooxindoles, spiroacenaphthylenes and spiro-2-amino-4H-pyrans under solvent-free conditions

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Abstract

For the first time, the organic salt Na2EDTA was used as a catalyst for an effective and facile preparation of spiro-4H-pyrans via single-pot three-component condensation of isatin/acenaphthoquinone/ninhydrin, malononitrile, and CH-acids through Knoevenagel–Michael–annulation sequence. This new protocol employing Na2EDTA, which is a green, recyclable, and inexpensive catalyst, offers advantages such as solvent-free and highly efficient reaction conditions, short reaction times (10–15 min), easy work-up and high yields which make it more economic than other environmentally synthetic methods.

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Acknowledgements

We gratefully appreciate the financial support from the Research Council of University of Sistan and Baluchestan.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P. O. Box 98135-674, Zahedan, Iran

    Tayebeh Jazinizadeh, Malek Taher Maghsoodlou & Reza Heydari

  2. Department of Biology, Science and Art University, Yazd, Iran

    Afshin Yazdani-Elah-Abadi

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  1. Tayebeh Jazinizadeh
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  2. Malek Taher Maghsoodlou
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  3. Reza Heydari
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  4. Afshin Yazdani-Elah-Abadi
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Correspondence to Malek Taher Maghsoodlou.

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Jazinizadeh, T., Maghsoodlou, M.T., Heydari, R. et al. Na2EDTA: an efficient, green and reusable catalyst for the synthesis of biologically important spirooxindoles, spiroacenaphthylenes and spiro-2-amino-4H-pyrans under solvent-free conditions. J IRAN CHEM SOC 14, 2117–2125 (2017). https://doi.org/10.1007/s13738-017-1148-3

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