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CaCl2 as a bifunctional reusable catalyst: diversity-oriented synthesis of 4H-pyran library under ultrasonic irradiation

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Abstract

CaCl2 is applied as an efficient reusable and eco-friendly bifunctional catalyst for the one-pot three-component synthesis of 4H-pyrans under ultrasonic irradiation. A broad range of substrates including the aromatic and heteroaromatic aldehydes, indoline-2,3-dione (isatin) derivatives, acenaphthylene-1,2-dione (acenaphthenequinone) and 2, 2-dihydroxy-2H-indene-1,3-dione (ninhydrin) were condensed with carbonyl compounds possessing a reactive α-methylene group and alkylmalonates. All reactions are completed in short times, and the products are obtained in good to excellent yields. The catalyst could be recycled and reused several times without any loss of efficiency.

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Authors and Affiliations

  1. Department of Applied Chemistry, Faculty of Science, Islamic Azad University, Shiraz Branch, P.O. Box 71993-5, Shiraz, Iran

    Hamid Reza Safaei, Mohsen Shekouhy, Athar Shirinfeshan & Sudabeh Rahmanpur

  2. Young Researchers Club, Islamic Azad University, Shiraz Branch, Shiraz, Iran

    Mohsen Shekouhy

Authors
  1. Hamid Reza Safaei
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  2. Mohsen Shekouhy
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  3. Athar Shirinfeshan
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  4. Sudabeh Rahmanpur
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Correspondence to Hamid Reza Safaei or Mohsen Shekouhy.

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Safaei, H.R., Shekouhy, M., Shirinfeshan, A. et al. CaCl2 as a bifunctional reusable catalyst: diversity-oriented synthesis of 4H-pyran library under ultrasonic irradiation. Mol Divers 16, 669–683 (2012). https://doi.org/10.1007/s11030-012-9392-z

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  • DOI: https://doi.org/10.1007/s11030-012-9392-z

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