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Sequential Structural and Fluid Dynamics Analysis of Balloon-Expandable Coronary Stents: A Multivariable Statistical Analysis

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Abstract

Several clinical studies have identified a strong correlation between neointimal hyperplasia following coronary stent deployment and both stent-induced arterial injury and altered vessel hemodynamics. As such, the sequential structural and fluid dynamics analysis of balloon-expandable stent deployment should provide a comprehensive indication of stent performance. Despite this observation, very few numerical studies of balloon-expandable coronary stents have considered both the mechanical and hemodynamic impact of stent deployment. Furthermore, in the few studies that have considered both phenomena, only a small number of stents have been considered. In this study, a sequential structural and fluid dynamics analysis methodology was employed to compare both the mechanical and hemodynamic impact of six balloon-expandable coronary stents. To investigate the relationship between stent design and performance, several common stent design properties were then identified and the dependence between these properties and both the mechanical and hemodynamic variables of interest was evaluated using statistical measures of correlation. Following the completion of the numerical analyses, stent strut thickness was identified as the only common design property that demonstrated a strong dependence with either the mean equivalent stress predicted in the artery wall or the mean relative residence time predicted on the luminal surface of the artery. These results corroborate the findings of the large-scale ISAR-STEREO clinical studies and highlight the crucial role of strut thickness in coronary stent design. The sequential structural and fluid dynamics analysis methodology and the multivariable statistical treatment of the results described in this study should prove useful in the design of future balloon-expandable coronary stents.

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Acknowledgments

This research was funded by Dublin Institute of Technology under the Fiosraigh scholarship programme. The authors would also like to acknowledge the SFI/HEA Irish Centre of High-End Computing for the provision of computational facilities and support.

Conflict of interest

David Martin and Fergal Boyle declare that they have no conflict of interest.

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  1. Department of Mechanical Engineering, Dublin Institute of Technology, Bolton Street, Dublin 1, Ireland

    David Martin & Fergal Boyle

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  1. David Martin
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  2. Fergal Boyle
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Correspondence to David Martin.

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Associate Editor James E. Moore oversaw the review of this article.

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Martin, D., Boyle, F. Sequential Structural and Fluid Dynamics Analysis of Balloon-Expandable Coronary Stents: A Multivariable Statistical Analysis. Cardiovasc Eng Tech 6, 314–328 (2015). https://doi.org/10.1007/s13239-015-0219-9

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