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Hemodynamics of Stent Implantation Procedures in Coronary Bifurcations: An In Vitro Study

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Abstract

Stent implantation in coronary bifurcations presents unique challenges and currently there is no universally accepted stent deployment approach. Despite clinical and computational studies, the effect of each stent implantation method on the coronary artery hemodynamics is not well understood. In this study the hemodynamics of stented coronary bifurcations under pulsatile flow conditions were investigated experimentally. Three implantation methods, provisional side branch (PSB), culotte (CUL), and crush (CRU), were investigated using time-resolved particle image velocimetry to measure the velocity fields. Subsequently, hemodynamic parameters including wall shear stress, oscillatory shear index (OSI), and relative residence time (RRT) were calculated. The pressure field through the vessel was non-invasively quantified and pressure wave speeds were computed. The effects of each stented case were evaluated and compared against an un-stented case. CRU provided the lowest compliance mismatch, but demonstrated detrimental stent interactions. PSB, the clinically preferred method, and CUL maintained many normal flow conditions. However, PSB provided about a 300% increase in both OSI and RRT. CUL yielded a 10 and 85% increase in OSI and RRT, respectively. The results of this study support the concept that different bifurcation stenting techniques result in hemodynamic environments that deviate from that of un-stented bifurcations, to varying degrees.

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Acknowledgments

The authors would like to thank Jaime S. Raben for her contributions to the initial efforts of this project. Pavlos Vlachos acknowledges partial support by NIH NHLBI Grant No HL106276-01A1. Claudio Chiastra is partially supported by the ERC starting grant (310457, BioCCora).

Conflict of Interest

Authors Melissa C. Brindise, Claudio Chiastra, Francesco Burzotta, Francesco Migliavacca, and Pavlos P. Vlachos have no conflicts of interest to report.

Human and Animal Rights

No human studies were carried out by the authors for this article. No animal studies were carried out by the authors for this article.

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Authors and Affiliations

  1. School of Mechanical Engineering, Purdue University, 585 Purdue Mall, West Lafayette, IN, 47907, USA

    Melissa C. Brindise & Pavlos P. Vlachos

  2. Laboratory of Biological Structure Mechanics (LaBS), Chemistry, Materials and Chemical Engineering Department “Giulio Natta”, Politecnico di Milano, Milan, Italy

    Claudio Chiastra & Francesco Migliavacca

  3. Department of Cardiology, Biomedical Engineering, Erasmus MC, Rotterdam, The Netherlands

    Claudio Chiastra

  4. Department of Cardiovascular Medicine, Università Cattolica del Sacro Cuore, Rome, Italy

    Francesco Burzotta

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  1. Melissa C. Brindise
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Correspondence to Pavlos P. Vlachos.

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Associate Editor Peter E. McHugh oversaw the review of this article.

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Brindise, M.C., Chiastra, C., Burzotta, F. et al. Hemodynamics of Stent Implantation Procedures in Coronary Bifurcations: An In Vitro Study. Ann Biomed Eng 45, 542–553 (2017). https://doi.org/10.1007/s10439-016-1699-y

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  • DOI: https://doi.org/10.1007/s10439-016-1699-y

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