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Progress of Selenium Deficiency in the Pathogenesis of Arthropathies and Selenium Supplement for Their Treatment

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Abstract

Selenium, an essential trace element for human health, exerts an indispensable effect in maintaining physiological homeostasis and functions in the body. Selenium deficiency is associated with arthropathies, such as Kashin-Beck disease, rheumatoid arthritis, osteoarthritis, and osteoporosis. Selenium deficiency mainly affects the normal physiological state of bone and cartilage through oxidative stress reaction and immune reaction. This review aims to explore the role of selenium deficiency and its mechanisms existed in the pathogenesis of arthropathies. Meanwhile, this review also summarized various experiments to highlight the crucial functions of selenium in maintaining the homeostasis of bone and cartilage.

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Abbreviations

BMD:

Bone mineral density

CAT:

Catalase

COX-2:

Cyclooxygenase-2

ECM:

Extracellular matrix

GPX:

Glutathione peroxidase

IL-1β:

Interleukin-1 beta

IL-6:

Interleukin-6

iNOS:

Inducible nitric oxide synthase

KBD:

Kashin-Beck disease

miR-138-5p:

MicroRNAs-138-5p

MMP13:

Matrix metalloproteinase 13

mTOR:

Mammalian target of rapamycin

OA:

Osteoarthritis

OP:

Osteoporosis

OPG:

Osteoprotegerin

PI3K:

Phosphatidylinositol 3-kinase

RA:

Rheumatoid arthritis

ROS:

Reactive oxygen species

SANFH:

Steroid-induced femoral head necrosis

Sec:

Selenocysteine

Se-CPC:

Selenium-modified calcium phosphate cement

SelM:

Selenoprotein M

SeMet:

Selenomethionine

SeNPs:

Selenium nanoparticles

SOD:

Superoxide dismutase

TNF-α:

Tumor necrosis factor alpha

TRAP:

Tartrate-resistant acid phosphatase

TrxR:

Thioredoxin reductase

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Funding

This study was supported by the National Natural Science Foundation of China (81872567).

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Author notes

  1. Huan Deng, Haobiao Liu and Zhihao Yang contributed equally.

Authors and Affiliations

  1. School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an, Shaanxi, 710061, People’s Republic of China

    Huan Deng, Haobiao Liu, Zhihao Yang, Miaoye Bao, Xue Lin & Jing Han

  2. Department of Odontology, Umeå University, 90187, Umeå, Sweden

    Chengjuan Qu

Authors
  1. Huan Deng
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  2. Haobiao Liu
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  3. Zhihao Yang
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  4. Miaoye Bao
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  5. Xue Lin
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  6. Jing Han
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  7. Chengjuan Qu
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Contributions

All authors participated in drafting the article and critically modifying the important content of knowledge, with all authors endorsing the final version. Study conception and design: Han, Deng. Literature and data collection: Deng, Liu, Yang, Bao, Lin. Drafting the article or revising it critically for important intellectual content: Han, Deng, Bao, Lin, Liu, Yang, Qu. Final approval of the version of the article to be published: Han, Deng, Liu, Yang, Bao, Lin, Qu.

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Correspondence to Jing Han.

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Deng, H., Liu, H., Yang, Z. et al. Progress of Selenium Deficiency in the Pathogenesis of Arthropathies and Selenium Supplement for Their Treatment. Biol Trace Elem Res 200, 4238–4249 (2022). https://doi.org/10.1007/s12011-021-03022-4

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  • DOI: https://doi.org/10.1007/s12011-021-03022-4

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