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Plasma Selenium, Zinc, Copper and Lipid Levels in Postmenopausal Turkish Women and Their Relation with Osteoporosis

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Abstract

It has been shown that the trace elements and lipids play role in the growth, development and maintenance of bones. We aimed to investigate serum selenium (Se), zinc (Zn), copper (Cu) and lipid (total cholesterol, triglyceride (TG), high density lipoprotein-cholesterol, low-density lipoprotein–cholesterol) levels in postmenopausal women with osteoporosis, osteopenia and in healthy controls, and to determine the relationship between Se, Zn, Cu and lipid parameters and bone mineral density (BMD). The study included 107 postmenopausal women; 35 healthy (group 1), 37 osteopenic (group 2) and 35 osteoporotic (group 3). The women in all three groups were carefully matched for body mass index (BMI). Serum concentrations of Se, Zn and Cu were measured by atomic absorption spectrophotometry. Plasma Se, Cu, Zn and lipid levels were similar in all groups (p > 0.05). When we combined the women in each of the three groups, and considered them as one group (n = 107) we found a positive correlation between BMI and lumbar vertebra BMD, femur neck BMD, femur total BMD; a positive correlation between TG and femur neck BMD, femur total BMD; a positive correlation between Zn and lumbar vertebra BMD (total T score) (p < 0.05). There was no correlation between Se, Cu, Zn, P and lipid parameters (p > 0.05). Although BMI has a positive effect on BMD, trace elements and lipids, except Zn and TG, did not directly and correlatively influence BMD. Further studies are needed to clarify the role and relationship of trace elements and lipid parameters in postmenopausal osteoporosis.

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None of the authors had any financial or other potential conflicts of interests concerning this paper.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Kahramanmaras Sutcu Imam University Medical Faculty, Kahramanmaras, Turkey

    Deniz Cemgil Arikan & Ayhan Coskun

  2. Department of Public Health, Inonu University Medical Faculty, Malatya, Turkey

    Ali Ozer

  3. Department of Biochemistry, Kahramanmaras Sutcu Imam University Medical Faculty, Kahramanmaras, Turkey

    Metin Kilinc, Filiz Atalay & Tugba Arikan

  4. Kahramanmaras Sutcu Imam Universitesi Tip Fakultesi, Kadin Hastaliklari ve Dogum Anabilim Dali, Yoruk Selim Mah. Hastane Cad. No. 32, 46050, Kahramanmaras, Turkey

    Deniz Cemgil Arikan

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  1. Deniz Cemgil Arikan
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Correspondence to Deniz Cemgil Arikan.

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Arikan, D.C., Coskun, A., Ozer, A. et al. Plasma Selenium, Zinc, Copper and Lipid Levels in Postmenopausal Turkish Women and Their Relation with Osteoporosis. Biol Trace Elem Res 144, 407–417 (2011). https://doi.org/10.1007/s12011-011-9109-7

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