Skip to main content
Log in

Plasma selenium levels in rheumatoid arthritis

  • Original Articles
  • Published:
Biological Trace Element Research Aims and scope Submit manuscript

Abstract

The plasma selenium (Se) levels were determined in patients with rheumatoid arthritis (RA) and healthy controls. Plasma Se levels in 60 patients were found to be significantly lower than those in 60 normal, healthy controls (p<0.001). Similar significant differences were determined in sex-matched comparisons between patients and controls (p<0.001) but there was no significant difference in plasma Se levels in sex-matched comparisons in both groups (p>0.05).

Our results suggest that Se is an important factor in RA.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. A. T. Diplock, Antioxidant nutrients and disease prevention: an overview.Am. J. Clin. Nutr. 53, 189S-193S (1991).

    PubMed  CAS  Google Scholar 

  2. G. Lockitch, Selenium: clinical significance and analytical concepts.Crit. Rev. Clin. Lab. Sci.,27, 483–541 (1989).

    Article  PubMed  CAS  Google Scholar 

  3. E. Munte, J. Aaseth, and E. Jellum, Trace elements and rheumatoid arthritis (RA)-pathogenetic and therapeutic aspects.Acta. Pharmacol. Toxicol.,59, (Suppl 7), 365–373 (1986).

    Google Scholar 

  4. J. R. O'dell, S. Lemley-Gillespie, W. R. Palmer, A. L. Weaver, G. F. Moore, and L. W. Klassen, Serum selenium concentrations in rheumatoid arthritis,Ann. Rheum. Dis.,50, 376–378 (1991).

    PubMed  Google Scholar 

  5. Food and Nutrition Board,National Research Council Recommended Dietary Allowances, 9th ed., National Academy of Sciences, Washington (1980).

    Google Scholar 

  6. Editorial: Rheumatoid arthritis and selenium,Nutr. Rev.,46, 284–286, (1988).

  7. J. Aaseth, E. T. Munthe, O. Fonre, and E. Steinnes, Trace elements in serum and urine of patients with rheumatoid arthritis.Scand. J. Rheumatol.,7, 237–240 1978.

    Article  PubMed  CAS  Google Scholar 

  8. U. Tarp, K. Overvad, J. C. Hansen, and E. B. Thorling, Low selenium level in severe rheumatoid arthritis.Scand. J. Rheumatol.,14, 97–101 (1985).

    Article  PubMed  CAS  Google Scholar 

  9. U. Tarp, K. Stenpaard-Pedersen, J. C. Hansen, and E. B. Thorling, Glutathione redox cycle enzymes and selenium in severe rheumatoid arthrifis: Lack of antioxidative response to selenium supplementation in polymorphonuclear leucocytes,Ann. Rheum. Dis.,51, 1044–1069 (1992).

    PubMed  CAS  Google Scholar 

  10. K. Köse, P. Doĝan, Y. Kardas, and R. Saraymen, Lipid peroxidation and antioxidant activity in rheumatoid arthritis.Tr. J. Med. Sci. 22, 31–34, 1994.

    Google Scholar 

  11. A. Peretz, J. Neve, F. Vertongen, J. P. Famaey, and L. Molle, Selenium status in relation to clinical variables and corticosteroid treatment in rheumatoid arthritis,J. Rheumatol.,14, 1104 (1987).

    PubMed  CAS  Google Scholar 

  12. F. C. Arnett, S. M. Edworthy, D. A. Bloch, The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis,Arthritis Rheum.,31, 315–324 (1988).

    Article  PubMed  CAS  Google Scholar 

  13. B. E. Jacobson and G. Lockitch, Direct determination of selenium in serum by graphite-furnace atomic absorbtion spectrometry with deuterium background correction and a reduced palladium modifier: age-specific reference ranges,Clin. Chem.,34, 709–714 (1988).

    PubMed  CAS  Google Scholar 

  14. B. Dawson-Saunders, and R. G. Trapp, Basic and Clinical Biostatistics, Appleton and Lange, Connecticut, 101–103, 1990.

    Google Scholar 

  15. E. D. Harris, Pathogenesis of rheumatoid arthritis.Textbook of Rheumatology, (Kelley, W. N. Ed.) W. B. Saunders, Philadelphia. 905–942, 1989.

    Google Scholar 

  16. J. Lunec, S. P. Halloren, A. G. White, and T. L. Dormandy, Free radical oxidation (peroxidation) products in serum and synovial fluid in rheumatoid arthritis,J. Rheumatol.,8, 233–245 (1981).

    PubMed  CAS  Google Scholar 

  17. R. D. Situanyake, D. I. Thurnham, S. Kootathep, S. Chirico, J. Lunec, M. Davis, and B. McConkey, Chain breaking antioxidant status in rheumatoid arthritis: Clinical and laboratory correlates.Ann. Rheum. Dis. 50, 81–86 (1991).

    Article  Google Scholar 

  18. P. Biemond, G. Swaak, and J. Koster, Protective factors against oxygen free radicals and hydrogen peroxide in rheumatoid arthritis synovial fluid,Arthritis Rheum.,27, 760–765 (1984).

    Article  PubMed  CAS  Google Scholar 

  19. M. L. Selley, D. J. Bourne, M. R. Bartlett, K. E. Tymms, A. S. Brook, A. M. Duffield, and N. G. Ardlie, Occurrence of (E)-4-hydroxy-2-nonela in plasma and synovial fluid of patients with rheumatoid arthritis and osteoarthritis.Ann. Rheum. Dis.,51, 481–484 (1992).

    PubMed  CAS  Google Scholar 

  20. M. J. Parnharm, J. Winkelman, and S. Leyck, Macrophage, lymphocyte and chronic inflammation responses in selenium deficient rodents,Int. J. Immunopharmacol.,5, 455–461 (1983).

    Article  Google Scholar 

  21. K. R. Maddipati and L. J. Marnet, Characterization of the major hydroperoxide reducing activity of human plasma.J. Biol. Chem.,262, 17398–17403 (1987).

    PubMed  CAS  Google Scholar 

  22. G. F. Combs, Jr. and S. B. Combs, The Role of Selenium in Nutrition, Academic, New York, NY, 205–263 (1986).

    Google Scholar 

  23. V. E. Honkanen, The factors effecting plasma glutathione peroxidase and selenium in rheumatoid arthritis: a multiple linear regression analyses.Scand. J. Rheumatol,20, 385–391 (1991).

    Article  PubMed  CAS  Google Scholar 

  24. V. Honkanen, Y. T. Konttiren, T. Sorsa, M. Hukkanen, P. Kemppinen, S. Santavirta, H. Saari, and T. Westermarok, Serum zinc, copper and selenium in rheumatoid arthritis,J. Trace Elem. Electrolytes Health Dis.,5, 261–263 (1991).

    PubMed  CAS  Google Scholar 

  25. U. Johansson, S. Portinsson, A. Akesson, H. Svantesson, P. A. Ockerman, and B. Akesson, Nutritional status in girls with juvenile rheumatoid arthritis.Hum. Nutr. Clin. Nutr.,40, C:57 (1985).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Köse, K., Doĝan, P., Kardas, Y. et al. Plasma selenium levels in rheumatoid arthritis. Biol Trace Elem Res 53, 51–56 (1996). https://doi.org/10.1007/BF02784544

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02784544

Index Entries

Navigation