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The Association Between Serum Selenium Levels with Rheumatoid Arthritis

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Abstract

There are conflicting reports on the correlation between serum selenium (Se) levels with rheumatoid arthritis (RA). Through a meta-analysis approach, the aim of the present study is to clarify the relationship between serum Se levels with RA. We searched literatures that met our predefined criteria in PubMed, ScienceDirect, and OVID published as of September 2015. Ten eligible articles with 14 case–control studies involving 716 subjects were identified. Overall, pooled analysis indicated that subjects with RA had lower serum levels of Se than the healthy controls (standardized mean difference (SMD) = −1.347, 95 % confidence interval (CI) = [−1.872, −0.823], p < 0.001). Further subgroup analysis indicated that subjects with RA had lower serum Se levels than healthy controls in Europe (SMD = −1.063, 95 % CI = [−1.571, −0.556], p < 0.001) and Asia (SMD = −3.254, 95 % CI = [−4.687, −1.821], p < 0.001) but not in USA (SMD = −0.322, 95 % CI = [−0.657, 0.012], p = 0.059). The serum Se levels were lower in RA than healthy controls measured by graphite furnace atom absorption spectrometry (GFAAS) (SMD = −1.026, 95 % CI = [−1.522, −0.530], p < 0.001), electrothermal absorption spectrometry (EAS) (SMD = −1.197, 95 % CI = [−2.373, −0.020], p < 0.05), flame atomic absorption spectrophotometry (FAAS) (SMD = −0.681, 95 % CI = [−1.049, −0.313], p < 0.001), and inductively coupled plasma–mass spectrophotometer (ICP-MS) (SMD = −11.707, 95 % CI = [−15.189, −8.224], p < 0.001) but not by neutron activation analysis (NAA) (SMD = −0.674, 95 % CI = [−1.350, 0.003], p = 0.051). In conclusion, this meta-analysis supports a significant association between low serum Se concentration with RA. However, this finding needs further confirmation by a trans-regional multicenter study to obtain better understanding of causal relationship between serum Se with RA of different human races or regions.

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References

  1. Tuncer S, Kamanli A, Akcil E, Kavas GO, Seckin B et al (1999) Trace element and magnesium levels and superoxide dismutase activity in rheumatoid arthritis. Biol Trace Elem Res 68:137–142

    Article  CAS  PubMed  Google Scholar 

  2. Strecker D, Mierzecki A, Radomska K (2013) Copper levels in patients with rheumatoid arthritis. Ann Agric Environ Med 20:312–316

    CAS  PubMed  Google Scholar 

  3. Xin L, Yang X, Cai G, Fan D, Xia Q, et al. (2015) Serum levels of copper and zinc in patients with rheumatoid arthritis: a meta-analysis. Biol Trace Elem Res

  4. Mertens K, Lowes DA, Webster NR, Talib J, Hall L et al (2015) Low zinc and selenium concentrations in sepsis are associated with oxidative damage and inflammation. Br J Anaesth 114:990–999

    Article  CAS  PubMed  Google Scholar 

  5. Shen F, Cai WS, Li JL, Feng Z, Cao J et al (2015) The association between serum levels of selenium, copper, and magnesium with thyroid cancer: a meta-analysis. Biol Trace Elem Res 167:225–235

    Article  CAS  PubMed  Google Scholar 

  6. Abdulah R, Kobayashi K, Yamazaki C, Koyama H (2011) Molecular targets of selenium in prostate cancer prevention (review). Int J Oncol 39:301–309

    CAS  PubMed  Google Scholar 

  7. Srivastava P, Braganca JM, Kowshik M (2014) In vivo synthesis of selenium nanoparticles by Halococcus salifodinae BK18 and their anti-proliferative properties against HeLa cell line. Biotechnol Prog 30:1480–1487

    Article  CAS  PubMed  Google Scholar 

  8. Duntas LH (2009) Selenium and inflammation: underlying anti-inflammatory mechanisms. Horm Metab Res 41:443–447

    Article  CAS  PubMed  Google Scholar 

  9. Ramya S, Shanmugasundaram T, Balagurunathan R (2015) Biomedical potential of actinobacterially synthesized selenium nanoparticles with special reference to anti-biofilm, anti-oxidant, wound healing, cytotoxic and anti-viral activities. J Trace Elem Med Biol 32:30–39

    Article  CAS  PubMed  Google Scholar 

  10. Saad MB, Gertner LR, Bona TD, Santin E (2009) Selenium influence in the poultry immune response—review. Recent Pat Food Nutr Agric 1:243–247

    Article  CAS  PubMed  Google Scholar 

  11. Ren J, Zhou Y, Wu H, Dai T, Zhu L (2014) Role and mechanism of NKp44 + NK cells in the proliferation and inflammation of synovium of rheumatoid arthritis patients. Zhonghua Yi Xue Za Zhi 94:201–203

    PubMed  Google Scholar 

  12. Bernard NJ (2014) Inflammation: a TLR5-TNF positive feedback loop in rheumatoid arthritis. Nat Rev Rheumatol 10:637

    Article  PubMed  Google Scholar 

  13. Mattmiller SA, Carlson BA, Sordillo LM (2013) Regulation of inflammation by selenium and selenoproteins: impact on eicosanoid biosynthesis. J Nutr Sci 2:e28

    CAS  PubMed  PubMed Central  Google Scholar 

  14. Yazar M, Sarban S, Kocyigit A, Isikan UE (2005) Synovial fluid and plasma selenium, copper, zinc, and iron concentrations in patients with rheumatoid arthritis and osteoarthritis. Biol Trace Elem Res 106:123–132

    Article  CAS  PubMed  Google Scholar 

  15. Aaseth J, Munthe E, Forre O, Steinnes E (1978) Trace elements in serum and urine of patients with rheumatoid arthritis. Scand J Rheumatol 7:237–240

    Article  CAS  PubMed  Google Scholar 

  16. Afridi HI, Talpur FN, Kazi TG, Brabazon D (2015) Estimation of toxic elements in the samples of different cigarettes and their effect on the essential elemental status in the biological samples of Irish smoker rheumatoid arthritis consumers. Environ Monit Assess 187:157

    Article  PubMed  Google Scholar 

  17. Heliovaara M, Knekt P, Aho K, Aaran RK, Alfthan G et al (1994) Serum antioxidants and risk of rheumatoid arthritis. Ann Rheum Dis 53:51–53

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Deeks JJ, Dinnes J, D’Amico R, Sowden AJ, Sakarovitch C, et al. (2003) Evaluating non-randomised intervention studies. Health Technol Assess 7: iii-x, 1–173.

  19. Witkowska AM, Kuryliszyn-Moskal A, Borawska MH, Hukalowicz K, Markiewicz R (2003) A study on soluble intercellular adhesion molecule-1 and selenium in patients with rheumatoid arthritis complicated by vasculitis. Clin Rheumatol 22:414–419

    Article  PubMed  Google Scholar 

  20. Jacobsson L, Lindgarde F, Manthorpe R, Akesson B (1990) Correlation of fatty acid composition of adipose tissue lipids and serum phosphatidylcholine and serum concentrations of micronutrients with disease duration in rheumatoid arthritis. Ann Rheum Dis 49:901–905

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Borglund M, Akesson A, Akesson B (1988) Distribution of selenium and glutathione peroxidase in plasma compared in healthy subjects and rheumatoid arthritis patients. Scand J Clin Lab Invest 48:27–32

    Article  CAS  PubMed  Google Scholar 

  22. Li J, Liang Y, Mao H, Deng W, Zhang J (2014) Effects of B-lymphocyte dysfunction on the serum copper, selenium and zinc levels of rheumatoid arthritis patients. Pak J Med Sci 30:1064–1067

    PubMed  PubMed Central  Google Scholar 

  23. Kose K, Dogan P, Kardas Y, Saraymen R (1996) Plasma selenium levels in rheumatoid arthritis. Biol Trace Elem Res 53:51–56

    Article  CAS  PubMed  Google Scholar 

  24. O’Dell JR, Lemley-Gillespie S, Palmer WR, Weaver AL, Moore GF et al (1991) Serum selenium concentrations in rheumatoid arthritis. Ann Rheum Dis 50:376–378

    Article  PubMed  PubMed Central  Google Scholar 

  25. Morco S, Bowden A (2015) Ulnar drift in rheumatoid arthritis: a review of biomechanical etiology. J Biomech 48:725–728

    Article  PubMed  Google Scholar 

  26. Entezami P, Fox DA, Clapham PJ, Chung KC (2011) Historical perspective on the etiology of rheumatoid arthritis. Hand Clin 27:1–10

    Article  PubMed  PubMed Central  Google Scholar 

  27. Onal S, Naziroglu M, Colak M, Bulut V, Flores-Arce MF (2011) Effects of different medical treatments on serum copper, selenium and zinc levels in patients with rheumatoid arthritis. Biol Trace Elem Res 142:447–455

    Article  CAS  PubMed  Google Scholar 

  28. Mirshafiey A, Mohsenzadegan M (2008) The role of reactive oxygen species in immunopathogenesis of rheumatoid arthritis. Iran J Allergy Asthma Immunol 7:195–202

    CAS  PubMed  Google Scholar 

  29. Gelderman KA, Hultqvist M, Olsson LM, Bauer K, Pizzolla A et al (2007) Rheumatoid arthritis: the role of reactive oxygen species in disease development and therapeutic strategies. Antioxid Redox Signal 9:1541–1567

    Article  CAS  PubMed  Google Scholar 

  30. Circu ML, Aw TY (2010) Reactive oxygen species, cellular redox systems, and apoptosis. Free Radic Biol Med 48:749–762

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Phillips DC, Dias HK, Kitas GD, Griffiths HR (2010) Aberrant reactive oxygen and nitrogen species generation in rheumatoid arthritis (RA): causes and consequences for immune function, cell survival, and therapeutic intervention. Antioxid Redox Signal 12:743–785

    Article  CAS  PubMed  Google Scholar 

  32. Chen Z, Liu Z, Li Z, Ju E, Gao N et al (2015) Upconversion nanoprobes for efficiently in vitro imaging reactive oxygen species and in vivo diagnosing rheumatoid arthritis. Biomaterials 39:15–22

    Article  CAS  PubMed  Google Scholar 

  33. Chitta KR, Landero Figueroa JA, Caruso JA, Merino EJ (2013) Selenium mediated arsenic toxicity modifies cytotoxicity, reactive oxygen species and phosphorylated proteins. Metallomics 5:673–685

    Article  CAS  PubMed  Google Scholar 

  34. Zhu Y, Paul P, Lee S, Craig BT, Rellinger EJ et al (2015) Antioxidant inhibition of steady-state reactive oxygen species and cell growth in neuroblastoma. Surgery 158:827–836

    Article  PubMed  Google Scholar 

  35. Sinha BK, Mimnaugh EG, Rajagopalan S, Myers CE (1989) Adriamycin activation and oxygen free radical formation in human breast tumor cells: protective role of glutathione peroxidase in adriamycin resistance. Cancer Res 49:3844–3848

    CAS  PubMed  Google Scholar 

  36. Suryo Rahmanto A, Pattison DI, Davies MJ (2012) Photo-oxidation-induced inactivation of the selenium-containing protective enzymes thioredoxin reductase and glutathione peroxidase. Free Radic Biol Med 53:1308–1316

    Article  CAS  PubMed  Google Scholar 

  37. Tarp U (1994) Selenium and the selenium-dependent glutathione peroxidase in rheumatoid arthritis. Dan Med Bull 41:264–274

    CAS  PubMed  Google Scholar 

  38. Tarp U (1990) Selenium glutathione peroxidase in rheumatoid arthritis. Br J Rheumatol 29:158

    Article  CAS  PubMed  Google Scholar 

  39. Nguyen SP, Bent S, Chen YH, Terdiman JP (2009) Gender as a risk factor for advanced neoplasia and colorectal cancer: a systematic review and meta-analysis. Clin Gastroenterol Hepatol 7(676–681):e671–673

    Google Scholar 

  40. Jin J, Yu M, Hu C, Ye L, Xie L et al (2014) Alcohol consumption and risk of myelodysplastic syndromes: a meta-analysis of epidemiological studies. Mol Clin Oncol 2:1115–1120

    PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Department of Rheumatology and Immunology, Guangzhou First People’s Hospital, Guangzhou Medical University, 1 Panfu Road, Yuexiu District, Guangzhou, Guangdong, 510180, People’s Republic of China

    Na Yu, Fang Han, Xiaojun Lin, Chun Tang, Jinghua Ye & Xiaoyan Cai

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  1. Na Yu
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  2. Fang Han
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Correspondence to Xiaoyan Cai.

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Yu, N., Han, F., Lin, X. et al. The Association Between Serum Selenium Levels with Rheumatoid Arthritis. Biol Trace Elem Res 172, 46–52 (2016). https://doi.org/10.1007/s12011-015-0558-2

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