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Biological and Genetic Markers in Occupational Asthma

  • Occupational Allergies (JA Poole, Section Editor)
  • Published:
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Abstract

Occupational asthma (OA) is a complex disease that is often hard to diagnose due to difficulties in detecting relevant exposure, along with inherent differences in disease susceptibility. Numerous studies have attempted to identify relevant biological and genetic markers for OA and to devise tools capable of detecting exposure to the causative agent. Immunological markers, including skin prick test reactivity and specific IgE and IgG antibodies can be used to detect high-molecular-weight allergens in cases of baker’s asthma. For OA induced by low-molecular-weight agents, such as isocyanate, potential biomarkers include serum-specific IgE and IgG antibodies to isocyanate-HSA conjugate and IgG to cytokeratin 19 and transglutaminase-2. For protein-based markers, ferritin/transferrin and vitamin D-binding protein levels have been suggested for isocyanate-OA. Genetic markers of susceptibility to isocyanate-OA include human leukocyte antigen and CTNNA3. Further investigations will be needed to identify better biomarkers for OA, which may be used to inform clinical decision.

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Gyu-Young Hur and Hae-Sim Park declare no conflict of interest.

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  1. Department of Internal Medicine, Korea University College of Medicine, 148 Gurodong-Ro, Guro, Seoul, 152-703, South Korea

    Gyu-Young Hur

  2. Department of Allergy and Clinical Immunology, Ajou University School of Medicine, 164 Worldcup-Ro, Youngtong, Suwon, 443-380, South Korea

    Hae-Sim Park

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Hur, GY., Park, HS. Biological and Genetic Markers in Occupational Asthma. Curr Allergy Asthma Rep 15, 488 (2015). https://doi.org/10.1007/s11882-014-0488-7

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