Skip to main content
SpringerLink
Log in

AFAP1-AS1: a rising star among oncogenic long non-coding RNAs

  • Review
  • Published:
Science China Life Sciences Aims and scope Submit manuscript

Abstract

Long non-coding RNAs (lncRNAs) have become a hotspot in biomedical research. This interest reflects their extensive involvement in the regulation of the expression of other genes, and their influence on the occurrence and development of a variety of human diseases. Actin filament associated protein 1-Antisense RNA 1(AFAP1-AS1) is a recently discovered oncogenic lncRNA. It is highly expressed in a variety of solid tumors, and regulates the expression of downstream genes and signaling pathways through adsorption and competing microRNAs, or by the direct binding to other proteins. Ultimately, AFAP1-AS1 promotes proliferation, chemotherapy resistance, and resistance to apoptosis, maintains stemness, and enhances invasion and migration of tumor cells. This paper summarizes the research concerning AFAP1-AS1 in malignant tumors, including the clinical application prospects of AFAP1-AS1 as a potential molecular marker and therapeutic target of malignant tumors. We also discuss the limitations in the knowledge of AFAP1-AS1 and directions of further research. AFAP1-AS1 is expected to provide an example for studies of other lncRNA molecules.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Bo, H., Fan, L., Gong, Z., Liu, Z., Shi, L., Guo, C., Li, X., Liao, Q., Zhang, W., Zhou, M., et al. (2019). Upregulation and hypomethylation of lncRNA AFAP1-AS1 predicts a poor prognosis and promotes the migration and invasion of cervical cancer. Oncol Rep 41, 2431–2439.

    CAS  PubMed  Google Scholar 

  • Bo, H., Fan, L., Li, J., Liu, Z., Zhang, S., Shi, L., Guo, C., Li, X., Liao, Q., Zhang, W., et al. (2018). High expression of lncRNA AFAP1-AS1 promotes the progression of colon cancer and predicts poor prognosis. J Cancer 9, 4677–4683.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bo, H., Gong, Z., Zhang, W., Li, X., Zeng, Y., Liao, Q., Chen, P., Shi, L., Lian, Y., Jing, Y., et al. (2015). Upregulated long non-coding RNA AFAP1-AS1 expression is associated with progression and poor prognosis of nasopharyngeal carcinoma. Oncotarget 6, 20404–20418.

    Article  PubMed  PubMed Central  Google Scholar 

  • Chen, B., Li, Q., Zhou, Y., Wang, X., Zhang, Q., Wang, Y., Zhuang, H., Jiang, X., and Xiong, W. (2018). The long coding RNA AFAP1-AS1 promotes tumor cell growth and invasion in pancreatic cancer through upregulating the IGF1R oncogene via sequestration of miR-133a. Cell Cycle 17, 1949–1966.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chen, G., Peng, L., Zhu, Z., Du, C., Shen, Z., Zang, R., Su, Y., Xia, Y., and Tang, W. (2017). LncRNA AFAP1-AS functions as a competing endogenous RNA to regulate RAP1B expression by sponging miR-181a in the HSCR. Int J Med Sci 14, 1022–1030.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Deng, J., Liang, Y., Liu, C., He, S., and Wang, S. (2015). The up-regulation of long non-coding RNA AFAP1-AS1 is associated with the poor prognosis of NSCLC patients. Biomed Pharmacother 75, 8–11.

    Article  CAS  PubMed  Google Scholar 

  • Ding, X., Zhang, S., Li, X., Feng, C., Huang, Q., Wang, S., Wang, S., Xia, W., Yang, F., Yin, R., et al. (2018). Profiling expression of coding genes, long noncoding RNA, and circular RNA in lung adenocarcinoma by ribosomal RNA-depleted RNA sequencing. FEBS Open Bio 8, 544–555.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Duan, S., Guo, W., Xu, Z., He, Y., Liang, C., Mo, Y., Wang, Y., Xiong, F., Guo, C., Li, Y., et al. (2019). Natural killer group 2D receptor and its ligands in cancer immune escape. Mol Cancer 18, 29.

    Article  PubMed  PubMed Central  Google Scholar 

  • Ecker, J.R., Bickmore, W.A., Barroso, I., Pritchard, J.K., Gilad, Y., and Segal, E. (2012). ENCODE explained. Nature 489, 52–54.

    Article  CAS  PubMed  Google Scholar 

  • Fan, C., Tang, Y., Wang, J., Wang, Y., Xiong, F., Zhang, S., Li, X., Xiang, B., Wu, X., Guo, C., et al. (2019). Long non-coding RNA LOC284454 promotes migration and invasion of nasopharyngeal carcinoma via modulating the Rho/Rac signaling pathway. Carcinogenesis 40, 380–391.

    Article  CAS  PubMed  Google Scholar 

  • Fan, C., Tang, Y., Wang, J., Xiong, F., Guo, C., Wang, Y., Xiang, B., Zhou, M., Li, X., Wu, X., et al. (2018). The emerging role of Epstein-Barr virus encoded microRNAs in nasopharyngeal carcinoma. J Cancer 9, 2852–2864.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Fan, C., Tang, Y., Wang, J., Xiong, F., Guo, C., Wang, Y., Zhang, S., Gong, Z., Wei, F., Yang, L., et al. (2017). Role of long non-coding RNAs in glucose metabolism in cancer. Mol Cancer 16, 130.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Feng, Y., Zhang, Q., Wang, J., and Liu, P. (2017). Increased lncRNA AFAP1-AS1 expression predicts poor prognosis and promotes malignant phenotypes in gastric cancer. Eur Rev Med Pharmacol Sci 21, 3842–3849.

    CAS  PubMed  Google Scholar 

  • Fu, X.L., Liu, D.J., Yan, T.T., Yang, J.Y., Yang, M.W., Li, J., Huo, Y.M., Liu, W., Zhang, J.F., Hong, J., et al. (2016). Analysis of long non-coding RNA expression profiles in pancreatic ductal adenocarcinoma. Sci Rep 6, 33535.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gao, S., Zhao, Z.Y., Wu, R., Zhang, Y., and Zhang, Z.Y. (2018). Prognostic value of long noncoding RNAs in gastric cancer: a meta-analysis. Onco Targets Ther Volume 11, 4877–4891.

    Article  Google Scholar 

  • Ge, J., Wang, J., Wang, H., Jiang, X., Liao, Q., Gong, Q., Mo, Y., Li, X., Li, G., Xiong, W., et al. (2020). The BRAF V600E mutation is a predictor of the effect of radioiodine therapy in papillary thyroid cancer. J Cancer 11, 932–939.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gong, Z., Yang, Q., Zeng, Z., Zhang, W., Li, X., Zu, X., Deng, H., Chen, P., Liao, Q., Xiang, B., et al. (2016). An integrative transcriptomic analysis reveals p53 regulated miRNA, mRNA, and lncRNA networks in nasopharyngeal carcinoma. Tumor Biol 37, 3683–3695.

    Article  CAS  Google Scholar 

  • Gong, Z., Zhang, S., Zeng, Z., Wu, H., Yang, Q., Xiong, F., Shi, L., Yang, J., Zhang, W., Zhou, Y., et al. (2014). LOC401317, a p53-regulated long non-coding RNA, inhibits cell proliferation and induces apoptosis in the nasopharyngeal carcinoma cell line HNE2. PLoS ONE 9, e110674.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Gong, Z.J., Zhang, S.S., Zhang, W.L., Huang, H.B., Li, Q., Deng, H., Ma, J., Zhou, M., Xiang, J.J., Wu, M.H., et al. (2012). Long non-coding RNAs in cancer. Sci China Life Sci 55, 1120–1124.

    Article  PubMed  Google Scholar 

  • Guo, J.Q., Li, S.J., and Guo, G.X. (2017). Long noncoding RNA AFAP1-AS1 promotes cell proliferation and apoptosis of gastric cancer cells via PTEN/p-AKT pathway. Dig Dis Sci 62, 2004–2010.

    Article  CAS  PubMed  Google Scholar 

  • Han, M., Gu, Y., Lu, P., Li, J., Cao, H., Li, X., Qian, X., Yu, C., Yang, Y., Yang, X., et al. (2020). Exosome-mediated lncRNA AFAP1-AS1 promotes trastuzumab resistance through binding with AUF1 and activating ERBB2 translation. Mol Cancer 19, 26.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Han, X., Wang, L., Ning, Y., Li, S., and Wang, Z. (2016). Long non-coding RNA AFAP1-AS1 facilitates tumor growth and promotes metastasis in colorectal cancer. Biol Res 49, 36.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • He, B., Li, W., Wu, Y., Wei, F., Gong, Z., Bo, H., Wang, Y., Li, X., Xiang, B., Guo, C., et al. (2016). Epstein-Barr virus-encoded miR-BART6-3p inhibits cancer cell metastasis and invasion by targeting long non-coding RNA LOC553103. Cell Death Dis 7, e2353.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • He, B., Zeng, J., Chao, W., Chen, X., Huang, Y., Deng, K., Huang, Z., Li, J., Dai, M., Chen, S., et al. (2017). Serum long non-coding RNAs MALAT1, AFAP1-AS1 and AL359062 as diagnostic and prognostic biomarkers for nasopharyngeal carcinoma. Oncotarget 8, 41166–41177.

    Article  PubMed  PubMed Central  Google Scholar 

  • He, J., Wu, K., Guo, C., Zhou, J.K., Pu, W., Deng, Y., Zuo, Y., Zhao, Y., Liu, L., Wei, Y.Q., et al. (2018). Long non-coding RNA AFAP1-AS1 plays an oncogenic role in promoting cell migration in non-small cell lung cancer. Cell Mol Life Sci 75, 4667–4681.

    Article  CAS  PubMed  Google Scholar 

  • He, Y., Jing, Y., Wei, F., Tang, Y., Yang, L., Luo, J., Yang, P., Ni, Q., Pang, J., Liao, Q., et al. (2018). Long non-coding RNA PVT1 predicts poor prognosis and induces radioresistance by regulating DNA repair and cell apoptosis in nasopharyngeal carcinoma. Cell Death Dis 9, 235.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Huang, N., Guo, W., Ren, K., Li, W., Jiang, Y., Sun, J., Dai, W., and Zhao, W. (2019). LncRNA AFAP1-AS1 supresses miR-139-5p and promotes cell proliferation and chemotherapy resistance of non-small cell lung cancer by competitively upregulating RRM2. Front Oncol 9, 1103.

    Article  PubMed  PubMed Central  Google Scholar 

  • Ji, D., Zhong, X., Jiang, X., Leng, K., Xu, Y., Li, Z., Huang, L., Li, J., and Cui, Y. (2018). The role of long non-coding RNA AFAP1-AS1 in human malignant tumors. Pathol Res Pract 214, 1524–1531.

    Article  CAS  PubMed  Google Scholar 

  • Jiang, X., Wang, J., Deng, X., Xiong, F., Ge, J., Xiang, B., Wu, X., Ma, J., Zhou, M., Li, X., et al. (2019). Role of the tumor microenvironment in PD-L1/PD-1-mediated tumor immune escape. Mol Cancer 18, 10.

    Article  PubMed  PubMed Central  Google Scholar 

  • Jiang, X.J., Wang, J., Deng, X.Y., Li, X.L., Li, X.Y., Zeng, Z.Y., Xiong, W., Li, G.Y., Xiong, F., and Guo, C. (2018). Immunotherapy targeted to immune checkpoint: a revolutionary breakthrough in cancer therapy. Prog Biochem Biophys 45, 1178–1186.

    Google Scholar 

  • Leng, X., Ding, X., Wang, S., Fang, T., Shen, W., Xia, W., You, R., Xu, K., and Yin, R. (2018). Long noncoding RNA AFAP1-AS1 is upregulated in NSCLC and associated with lymph node metastasis and poor prognosis. Oncol Lett 16, 727–732.

    PubMed  PubMed Central  Google Scholar 

  • Li, Q., Dai, Y., Wang, F., and Hou, S. (2016). Differentially expressed long non-coding RNAs and the prognostic potential in colorectal cancer. Neoplasma 63, 977–983.

    Article  CAS  PubMed  Google Scholar 

  • Li, R., Liu, S., Li, Y., Tang, Q., Xie, Y., and Zhai, R. (2018). Long noncoding RNA AFAP1-AS1 enhances cell proliferation and invasion in osteosarcoma through regulating miR-4695-5p/TCF4-β-catenin signaling. Mol Med Report 18, 1616–1622.

    CAS  Google Scholar 

  • Li, W., Li, N., Kang, X., and Shi, K. (2017). Circulating long non-coding RNA AFAP1-AS1 is a potential diagnostic biomarker for non-small cell lung cancer. Clin Chim Acta 475, 152–156.

    Article  CAS  PubMed  Google Scholar 

  • Li, Z., Ding, Z., Rong, D., Tang, W., and Cao, H. (2019). Overexpression of lncRNA AFAP1-AS1 promotes cell proliferation and invasion in gastric cancer. Oncol Lett 18, 3211–3217.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Lian, Y., Li, X.Y., Tang, Y.Y., Yang, L.T., Li, X.L., Xiong, W., Li, G.Y., and Zeng, Z.Y. (2016). Long non-coding RNAs function as competing endogenous RNAs to regulate cancer progression. Prog Biochem Biophys 43, 219–225.

    Google Scholar 

  • Lian, Y., Xiong, F., Yang, L., Bo, H., Gong, Z., Wang, Y., Wei, F., Tang, Y., Li, X., Liao, Q., et al. (2018). Long noncoding RNA AFAP1-AS1 acts as a competing endogenous RNA of miR-423-5p to facilitate nasopharyngeal carcinoma metastasis through regulating the Rho/Rac pathway. J Exp Clin Cancer Res 37, 253.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lin, D., Huang, Q., Wu, R., Dai, S., Huang, Z., Ren, L., Huang, S., and Chen, Q. (2019). Long non-coding RNA AFAP1-AS1 promoting epithelial-mesenchymal transition of endometriosis is correlated with transcription factor ZEB1. Am J Reprod Immunol 81, e13074.

    Article  PubMed  CAS  Google Scholar 

  • Liu, F.T., Xue, Q.Z., Zhu, P.Q., Luo, H.L., Zhang, Y., and Hao, T. (2016). Long noncoding RNA AFAP1-AS1, a potential novel biomarker to predict the clinical outcome of cancer patients: a meta-analysis. Onco Targets Ther Volume 9, 4247–4254.

    Article  Google Scholar 

  • Liu, R.H., Wang, M.Y., Chen, L.Y., Yin, Z.J., Ji, Q.K., Wang, Y.Y., and Jin, B.Z. (2018). Meta-analysis of the prognostic value of long non-coding RNA AFAP1-AS1 for cancer patients in China. Oncotarget 9, 8100–8110.

    Article  PubMed  Google Scholar 

  • Liu, W., Li, Y., Zhang, Y., Shen, X., Su, Z., Chen, L., Cai, W., Wang, F., and Ju, S. (2020). Circulating long non-coding RNA FEZF1-AS1 and AFAP1-AS1 serve as potential diagnostic biomarkers for gastric cancer. Pathol Res Pract 216, 152757.

    Article  CAS  PubMed  Google Scholar 

  • Lou, S., Xu, J., Wang, B., Li, S., Ren, J., Hu, Z., Xu, B., and Luo, F. (2019). Downregulation of lncRNA AFAP1-AS1 by oridonin inhibits the epithelial-to-mesenchymal transition and proliferation of pancreatic cancer cells. Acta Biochim Biophys Sin 51, 814–825.

    Article  CAS  PubMed  Google Scholar 

  • Lu, X., Zhou, C., Li, R., Liang, Z., Zhai, W., Zhao, L., and Zhang, S. (2016). Critical role for the long non-coding RNA AFAP1-AS1 in the proliferation and metastasis of hepatocellular carcinoma. Tumor Biol 37, 9699–9707.

    Article  CAS  Google Scholar 

  • Ma, D., Chen, C., Wu, J., Wang, H., and Wu, D. (2019). Up-regulated lncRNA AFAP1-AS1 indicates a poor prognosis and promotes carcinogenesis of breast cancer. Breast Cancer 26, 74–83.

    Article  PubMed  Google Scholar 

  • Ma, F., Wang, S.H., Cai, Q., Zhang, M.D., Yang, Y., and Ding, J. (2016). Overexpression of LncRNA AFAP1-AS1 predicts poor prognosis and promotes cells proliferation and invasion in gallbladder cancer. Biomed Pharmacother 84, 1249–1255.

    Article  CAS  PubMed  Google Scholar 

  • Mo, X., Wu, Y., Chen, L., Zhai, M., Gao, Z., Hu, K., and Guo, J. (2019). Global expression profiling of metabolic pathway-related lncRNAs in human gastric cancer and the identification of RP11-555H23.1 as a new diagnostic biomarker. J Clin Lab Anal 33, e22692.

    Article  PubMed  CAS  Google Scholar 

  • Mu, Z., Dong, D., Wei, N., Sun, M., Wang, W., Shao, Y., Gao, J., Yin, P., and Zhao, C. (2019). Silencing of lncRNA AFAP1-AS1 inhibits cell growth and metastasis in clear cell renal cell carcinoma. Oncol Res 27, 653–661.

    Article  PubMed  PubMed Central  Google Scholar 

  • Peng, B., Liu, A., Yu, X., Xu, E., Dai, J., Li, M., and Yang, Q. (2017). Silencing of lncRNA AFAP1-AS1 suppressed lung cancer development by regulatory mechanism in cis and trans. Oncotarget 8, 93608–93623.

    Article  PubMed  PubMed Central  Google Scholar 

  • Peng, M., Mo, Y., Wang, Y., Wu, P., Zhang, Y., Xiong, F., Guo, C., Wu, X., Li, Y., Li, X., et al. (2019). Neoantigen vaccine: an emerging tumor immunotherapy. Mol Cancer 18, 128.

    Article  PubMed  PubMed Central  Google Scholar 

  • Ren, D., Hua, Y., Yu, B., Ye, X., He, Z., Li, C., Wang, J., Mo, Y., Wei, X., Chen, Y., et al. (2020). Predictive biomarkers and mechanisms underlying resistance to PD1/PD-L1 blockade cancer immunotherapy. Mol Cancer 19, 19.

    Article  PubMed  PubMed Central  Google Scholar 

  • Roth, A., Boulay, K., Groß, M., Polycarpou-Schwarz, M., Mallette, F.A., Regnier, M., Bida, O., Ginsberg, D., Warth, A., Schnabel, P.A., et al. (2018). Targeting LINC00673 expression triggers cellular senescence in lung cancer. RNA Biol 15, 1499–1511.

    Article  PubMed  PubMed Central  Google Scholar 

  • Shi, D., Wu, F., Mu, S., Hu, B., Zhong, B., Gao, F., Qing, X., Liu, J., Zhang, Z., and Shao, Z. (2019). LncRNA AFAP1-AS1 promotes tumorigenesis and epithelial-mesenchymal transition of osteosarcoma through RhoC/ROCK1/p38MAPK/Twist1 signaling pathway. J Exp Clin Cancer Res 38, 375.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Song, Y., Li, X., Zeng, Z., Li, Q., Gong, Z., Liao, Q., Li, X., Chen, P., Xiang, B., Zhang, W., et al. (2016). Epstein-Barr virus encoded miR-BART11 promotes inflammation-induced carcinogenesis by targeting FOXP1. Oncotarget 7, 36783–36799.

    Article  PubMed  PubMed Central  Google Scholar 

  • Tang, H.X., Zhu, D., Zhang, G., Luo, X., and Xie, W. (2019). AFAP1-AS1 promotes proliferation of pituitary adenoma cells through miR-103a-3p to activate PI3K/AKT signaling pathway. World Neurosurg 130, e888–e898.

    Article  PubMed  Google Scholar 

  • Tang, J., Zhong, G., Wu, J., Chen, H., and Jia, Y. (2018). Long noncoding RNA AFAP1-AS1 facilitates tumor growth through enhancer of zeste homolog 2 in colorectal cancer. Am J Cancer Res 8, 892–902.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Tang, L., Wei, F., Wu, Y., He, Y., Shi, L., Xiong, F., Gong, Z., Guo, C., Li, X., Deng, H., et al. (2018). Role of metabolism in cancer cell radioresistance and radiosensitization methods. J Exp Clin Cancer Res 37, 87.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Tang, X.D., Zhang, D.D., Jia, L., Ji, W., and Zhao, Y.S. (2018). lncRNA AFAP1-AS1 promotes migration and invasion of non-small cell lung cancer via up-regulating IRF7 and the RIG-I-like receptor signaling pathway. Cell Physiol Biochem 50, 179–195.

    Article  CAS  PubMed  Google Scholar 

  • Tang, Y., He, Y., Shi, L., Yang, L., Wang, J., Lian, Y., Fan, C., Zhang, P., Guo, C., Zhang, S., et al. (2017). Co-expression of AFAP1-AS1 and PD-1 predicts poor prognosis in nasopharyngeal carcinoma. Oncotarget 8, 39001–39011.

    Article  PubMed  PubMed Central  Google Scholar 

  • Tang, Y., He, Y., Zhang, P., Wang, J., Fan, C., Yang, L., Xiong, F., Zhang, S., Gong, Z., Nie, S., et al. (2018). LncRNAs regulate the cytoskeleton and related Rho/ROCK signaling in cancer metastasis. Mol Cancer 17, 77.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Tang, Y., Wang, J., Lian, Y., Fan, C., Zhang, P., Wu, Y., Li, X., Xiong, F., Li, X., Li, G., et al. (2017). Linking long non-coding RNAs and SWI/SNF complexes to chromatin remodeling in cancer. Mol Cancer 16, 42.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Tay, Y., Kats, L., Salmena, L., Weiss, D., Tan, S.M., Ala, U., Karreth, F., Poliseno, L., Provero, P., Di Cunto, F., et al. (2011). Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs. Cell 147, 344–357.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wang, F., Ni, H., Sun, F., Li, M., and Chen, L. (2016). Overexpression of lncRNA AFAP1-AS1 correlates with poor prognosis and promotes tumorigenesis in colorectal cancer. Biomed Pharmacother 81, 152–159.

    Article  CAS  PubMed  Google Scholar 

  • Wang, M., Ma, X., Zhu, C., Guo, L., Li, Q., Liu, M., and Zhang, J. (2016). The prognostic value of long non coding RNAs in non small cell lung cancer: a meta-analysis. Oncotarget 7, 81292–81304.

    Article  PubMed  PubMed Central  Google Scholar 

  • Wang, Y. and Lan, Q. (2018). Long non-coding RNA AFAP1-AS1 accelerates invasion and predicts poor prognosis of glioma. Eur Rev Med Pharmacol Sci 22, 5223–5229.

    CAS  PubMed  Google Scholar 

  • Wang, Y.A., Li, X.L., Mo, Y.Z., Fan, C.M., Tang, L., Xiong, F., Guo, C., Xiang, B., Zhou, M., Ma, J., et al. (2018). Effects of tumor metabolic microenvironment on regulatory T cells. Mol Cancer 17, 168.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wang, Y., Mo, Y., Yang, X., Zhou, R., Wu, Z., He, Y., Yang, X., Zhong, Y., Du, Y., Zhou, H., et al. (2017). Long non-coding RNA AFAP1-AS1 is a novel biomarker in various cancers: a systematic review and meta-analysis based on the literature and GEO datasets. Oncotarget 8, 102346.

    Article  PubMed  PubMed Central  Google Scholar 

  • Wang, Y., Xue, D., Li, Y., Pan, X., Zhang, X., Kuang, B., Zhou, M., Li, X., Xiong, W., Li, G., et al. (2016). The long noncoding RNA MALAT-1 is a novel biomarker in various cancers: a meta-analysis based on the GEO database and literature. J Cancer 7, 991–1001.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wei, F., Jing, Y.Z., He, Y., Tang, Y. Y., Yang, L. T., Wu, Y. F., Tang, L., Shi, L., Gong, Z.J., Guo, C., et al. (2019). Cloning and characterization of the putative AFAP1-AS1 promoter region. J Cancer 10, 1145–1153.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wei, Y., and Zhang, X. (2016). Transcriptome analysis of distinct long non-coding RNA transcriptional fingerprints in lung adenocarcinoma and squamous cell carcinoma. Tumor Biol 37, 16275–16285.

    Article  CAS  Google Scholar 

  • Wu, P., Mo, Y., Peng, M., Tang, T., Zhong, Y., Deng, X., Xiong, F., Guo, C., Wu, X., Li, Y., et al. (2020). Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA. Mol Cancer 19, 22.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wu, W., Bhagat, T.D., Yang, X., Song, J.H., Cheng, Y., Agarwal, R., Abraham, J.M., Ibrahim, S., Bartenstein, M., Hussain, Z., et al. (2013). Hypomethylation of noncoding DNA regions and overexpression of the long noncoding RNA, AFAP1-AS1, in Barrett’s esophagus and esophageal adenocarcinoma. Gastroenterology 144, 956–966.e4.

    Article  CAS  PubMed  Google Scholar 

  • Wu, X.B., Feng, X., Chang, Q.M., Zhang, C.W., Wang, Z.F., Liu, J., Hu, Z. Q., Liu, J.Z., Wu, W.D., Zhang, Z.P., et al. (2019). Cross-talk among AFAP1-AS1, ACVR1 and microRNA-384 regulates the stemness of pancreatic cancer cells and tumorigenicity in nude mice. J Exp Clin Cancer Res 38, 107.

    Article  PubMed  PubMed Central  Google Scholar 

  • Xi, Y., Shi, J., Li, W., Tanaka, K., Allton, K.L., Richardson, D., Li, J., Franco, H.L., Nagari, A., Malladi, V.S., et al. (2018). Histone modification profiling in breast cancer cell lines highlights commonalities and differences among subtypes. BMC Genomics 19, 150.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Yan, Q., Zeng, Z., Gong, Z., Zhang, W., Li, X., He, B., Song, Y., Li, Q., Zeng, Y., Liao, Q., et al. (2015). EBV-miR-BART10-3p facilitates epithelial-mesenchymal transition and promotes metastasis of nasopharyngeal carcinoma by targeting BTRC. Oncotarget 6, 41766–41782.

    Article  PubMed  PubMed Central  Google Scholar 

  • Yang, L., Tang, Y., He, Y., Wang, Y., Lian, Y., Xiong, F., Shi, L., Zhang, S., Gong, Z., Zhou, Y., et al. (2017). High Expression of LINC01420 indicates an unfavorable prognosis and modulates cell migration and invasion in nasopharyngeal carcinoma. J Cancer 8, 97–103.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yang, L., Tang, Y., Xiong, F., He, Y., Wei, F., Zhang, S., Guo, C., Xiang, B., Zhou, M., Xie, N., et al. (2018). LncRNAs regulate cancer metastasis via binding to functional proteins. Oncotarget 9, 1426–1443.

    Article  PubMed  Google Scholar 

  • Yang, X., Yang, M., Deng, H., and Ding, Y. (2018). New era of studying RNA secondary structure and its influence on gene regulation in plants. Front Plant Sci 9, 671.

    Article  PubMed  PubMed Central  Google Scholar 

  • Ye, F., Gong, Y., Chen, X., Yu, M., Zuo, Z., Pei, D., Liu, W., Wang, Q., Zhou, J., Duan, L., et al. (2018). Long noncoding AFAP1-antisense RNA 1 is upregulated and promotes tumorigenesis in gastric cancer. Oncol Lett 15, 7523–7530.

    PubMed  PubMed Central  Google Scholar 

  • Ye, Q., Ling, S., Zheng, S., and Xu, X. (2019). Liquid biopsy in hepatocellular carcinoma: circulating tumor cells and circulating tumor DNA. Mol Cancer 18, 114.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Ye, Y., Chen, J., Zhou, Y., Fu, Z., Zhou, Q., Wang, Y.X., Gao, W., Zheng, S. Y., Zhao, X., Chen, T., et al. (2015). High expression of AFAP1-AS1 is associated with poor survival and short-term recurrence in pancreatic ductal adenocarcinoma. J Transl Med 13, 137.

    Article  PubMed  PubMed Central  Google Scholar 

  • Yin, D., Lu, X., Su, J., He, X., De, W., Yang, J., Li, W., Han, L., and Zhang, E. (2018). Long noncoding RNA AFAP1-AS1 predicts a poor prognosis and regulates non-small cell lung cancer cell proliferation by epigenetically repressing p21 expression. Mol Cancer 17, 92.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Yu, J., Liu, Y., Gong, Z., Zhang, S., Guo, C., Li, X., Tang, Y., Yang, L., He, Y., Wei, F., et al. (2017a). Overexpression long non-coding RNA LINC00673 is associated with poor prognosis and promotes invasion and metastasis in tongue squamous cell carcinoma. Oncotarget 8, 16621–16632.

    Article  PubMed  Google Scholar 

  • Yu, J., Liu, Y., Guo, C., Zhang, S., Gong, Z., Tang, Y., Yang, L., He, Y., Lian, Y., Li, X., et al. (2017b). Upregulated long non-coding RNA LINC00152 expression is associated with progression and poor prognosis of tongue squamous cell carcinoma. J Cancer 8, 523–530.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yu, S., Yang, D., Ye, Y., Liu, P., Chen, Z., Lei, T., Pu, J., Liu, L., and Wang, Z. (2019). Long noncoding RNA actin filament-associated protein 1 antisense RNA 1 promotes malignant phenotype through binding with lysine-specific demethylase 1 and repressing HMG box-containing protein 1 in non-small-cell lung cancer. Cancer Sci 110, 2211–2225.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yuan, X.H., Li, J., Cao, Y., Jie, Z.G., and Zeng, Y.F. (2020). Long non-coding RNA AFAP1-AS1 promotes proliferation and migration of gastric cancer by downregulating KLF2. Eur Rev Med Pharmacol Sci 24, 673–680.

    PubMed  Google Scholar 

  • Yuan, Z., Xiu, C., Song, K., Pei, R., Miao, S., Mao, X., Sun, J., and Jia, S. (2018). Long non-coding RNA AFAP1-AS1/miR-320a/RBPJ axis regulates laryngeal carcinoma cell stemness and chemoresistance. J Cell Mol Med 22, 4253–4262.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zeng, Z., Bo, H., Gong, Z., Lian, Y., Li, X., Li, X., Zhang, W., Deng, H., Zhou, M., Peng, S., et al. (2016). AFAP1-AS1, a long noncoding RNA upregulated in lung cancer and promotes invasion and metastasis. Tumor Biol 37, 729–737.

    Article  CAS  Google Scholar 

  • Zeng, Z., Fan, S., Zhang, X., Li, S., Zhou, M., Xiong, W., Tan, M., Zhang, W., and Li, G. (2016). Epstein-Barr virus-encoded small RNA 1 (EBER-1) could predict good prognosis in nasopharyngeal carcinoma. Clin Transl Oncol 18, 206–211.

    Article  CAS  PubMed  Google Scholar 

  • Zhang, J.Y., Weng, M.Z., Song, F.B., Xu, Y.G., Liu, Q.I., Wu, J.Y., Qin, J., Jin, T., and Xu, J.M. (2016). Long noncoding RNA AFAP1-AS1 indicates a poor prognosis of hepatocellular carcinoma and promotes cell proliferation and invasion via upregulation of the RhoA/Rac2 signaling. Int J Oncol 48, 1590–1598.

    Article  CAS  PubMed  Google Scholar 

  • Zhang, K., Liu, P., Tang, H., Xie, X., Kong, Y., Song, C., Qiu, X., and Xiao, X. (2018). AFAP1-AS1 promotes epithelelial-mesenchymal transition and tumorigenesis through Wnt/β-Catenin signaling pathway in triple-negative breast cancer. Front Pharmacol 9.

  • Zhang, W., Huang, C., Gong, Z., Zhao, Y., Tang, K., Li, X., Fan, S., Shi, L., Li, X., Zhang, P., et al. (2013). Expression of LINC00312, a long intergenic non-coding RNA, is negatively correlated with tumor size but positively correlated with lymph node metastasis in nasopharyngeal carcinoma. J Mol Hist 44, 545–554.

    Article  CAS  Google Scholar 

  • Zhao, H., Zhang, K., Wang, T., Cui, J., Xi, H., Wang, Y., Song, Y., Zhao, X., Wei, B., and Chen, L. (2018). Long non-coding RNA AFAP1-antisense RNA 1 promotes the proliferation, migration and invasion of gastric cancer cells and is associated with poor patient survival. Oncol Lett 15, 8620–8626.

    PubMed  PubMed Central  Google Scholar 

  • Zhao, Y., Chu, Y., Sun, J., Song, R., Li, Y., and Xu, F. (2019). LncRNA GAS8-AS inhibits colorectal cancer (CRC) cell proliferation by downregulating lncRNA AFAP1-AS1. Gene 710, 140–144.

    Article  CAS  PubMed  Google Scholar 

  • Zhao, Y., Li, H., Fang, S., Kang, Y., Wu, W., Hao, Y., Li, Z., Bu, D., Sun, N., Zhang, M.Q., et al. (2016). NONCODE 2016: an informative and valuable data source of long non-coding RNAs. Nucleic Acids Res 44, D203–D208.

    Article  CAS  PubMed  Google Scholar 

  • Zhong, Y., Wu, X., Li, Q., Ge, X., Wang, F., Wu, P., Deng, X., and Miao, L. (2019). Long noncoding RNAs as potential biomarkers and therapeutic targets in gallbladder cancer: a systematic review and meta-analysis. Cancer Cell Int 19, 169.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Zhong, Y., Yang, L., Xiong, F., He, Y., Tang, Y., Shi, L., Fan, S., Li, Z., Zhang, S., Gong, Z., et al. (2021). Long non-coding RNA AFAP1-AS1 accelerates lung cancer cells migration and invasion by interacting with SNIP1 to upregulate c-Myc. Signal Transduct Target Ther, doi: https://doi.org/10.1038/s41392-021-00562-y.

  • Zhou, J., Liu, M., Chen, Y., Xu, S., Guo, Y., and Zhao, L. (2019). Cucurbitacin B suppresses proliferation of pancreatic cancer cells by ceRNA: effect of miR-146b-5p and lncRNA-AFAP1-AS1. J Cell Physiol 234, 4655–4667.

    Article  CAS  PubMed  Google Scholar 

  • Zhou, Y., Chen, S., Cheng, S., Wei, Q., Fathy, A.H., and Shan, T. (2018). The prognostic value of high LncRNA AFAP1-AS1 expression in various cancers: a systematic review and meta-analysis containing 21 studies. Clin Chim Acta 481, 147–153.

    Article  CAS  PubMed  Google Scholar 

  • Zhuang, Y., Jiang, H., Li, H., Dai, J., Liu, Y., Li, Y., Miao, L., Cai, H., Xiao, Y., Xia, H., et al. (2017). Down-regulation of long non-coding RNA AFAP1-AS1 inhibits tumor cell growth and invasion in lung adeno-carcinoma. Am J Transl Res 9, 2997–3005.

    CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

This work was supported partially by grants from the National Natural Science Foundation of China (82073135, 82072374, 82003243, 81903138, 81803025) and the Natural Science Foundation of Hunan Province (2019JJ50872, 2020JJ4766).

Author information

Authors and Affiliations

  1. Science and Technology on Information System Engineering Laboratory, National University of Defense Technology, Changsha, 410000, China

    Fang Xiong, Su Deng & Hongbin Huang

  2. Department of Periodontology, Center of Stomatology, Xiangya Hospital, Central South University, Changsha, 410078, China

    Fang Xiong, Liting Yang & Shanshan Zhang

  3. NHC Key Laboratory of Carcinogenesis and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education of China, Cancer Research Institute, Central South University, Changsha, 410078, China

    Fang Xiong, Xiaoling Li, Guiyuan Li, Zhaoyang Zeng, Wei Xiong & Can Guo

  4. Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, China

    Kunjie Zhu, Yi He, Yanyan Tang, Qianjin Liao & Jianjun Yu

  5. Department of Oral and Maxillofacial Surgery, The Second Xiangya Hospital Central South University, Changsha, 410011, China

    Zhaojian Gong & Lei Shi

  6. Department of Medicine, Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, USA

    Yong Li

Authors
  1. Fang Xiong
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kunjie Zhu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Su Deng
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Hongbin Huang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Liting Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Zhaojian Gong
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Lei Shi
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Yi He
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Yanyan Tang
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Qianjin Liao
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Jianjun Yu
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Xiaoling Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Yong Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. Guiyuan Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  15. Zhaoyang Zeng
    View author publications

    You can also search for this author in PubMed Google Scholar

  16. Wei Xiong
    View author publications

    You can also search for this author in PubMed Google Scholar

  17. Shanshan Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  18. Can Guo
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Shanshan Zhang or Can Guo.

Additional information

Compliance and ethics

The author(s) declare that they have no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Xiong, F., Zhu, K., Deng, S. et al. AFAP1-AS1: a rising star among oncogenic long non-coding RNAs. Sci. China Life Sci. 64, 1602–1611 (2021). https://doi.org/10.1007/s11427-020-1874-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11427-020-1874-6

Keywords

Search

Navigation