Abstract
Dihydropyrimidinethione podands, as well as podands containing 2-thienyl substituents have been synthesized via the multicomponent Biginelli reaction. Tuberculostatic activity of the novel podands was shown to depend on the polyether unit length. In particular, activity of dihydropyrimidinethione podands against laboratory strains of Mycobacterium tuberculosis, H37Rv, M. avium, M. terrae, and the clinical strain of multi-drug resistant M. tuberculosis (MDR), increases with a shortening of the polyether unit length.
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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 4, pp. 0743–0746, April, 2018.
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Fedorova, O.V., Filatova, E.S., Titova, Y.A. et al. Multicomponent reactions in the synthesis of dihydropyrimidine-containing podands having tuberculostatic activity. Russ Chem Bull 67, 743–746 (2018). https://doi.org/10.1007/s11172-018-2131-6
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DOI: https://doi.org/10.1007/s11172-018-2131-6