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Natural Phenolic Compounds with Neuroprotective Effects

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Abstract

Neurodegenerative disorders are characterized by mitochondrial dysfunction and subsequently oxidative stress, inflammation, and apoptosis that contribute to neuronal cytotoxicity and degeneration. Huntington’s (HD), Alzheimer’s (AD), and Parkinson’s (PD) diseases are three of the major neurodegenerative diseases. To date, researchers have found various natural phytochemicals that could potentially be used to treat neurodegenerative diseases. Particularly, the application of natural phenolic compounds has gained significant traction in recent years, driven by their various biological activities and therapeutic efficacy in human health. Polyphenols, by modulating different cellular functions, play an important role in neuroprotection and can neutralize the effects of oxidative stress, inflammation, and apoptosis in animal models. This review focuses on the current state of knowledge on phenolic compounds, including phenolic acids, flavonoids, stilbenes, and coumarins, as well as their beneficial effects on human health. We further provide an overview of the therapeutic potential and mechanisms of action of natural dietary phenolics in curing neurodegenerative diseases in animal models.

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Authors and Affiliations

  1. Department of Agriculture, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Tehran, 1983969411, Iran

    Mansoureh Tavan & Mohammad Hossein Mirjalili

  2. Department of Biotechnology, Faculty of Biological Science, Alzahra University, Tehran, Iran

    Mansoureh Tavan & Parichehr Hanachi

  3. Department of Analytical Chemistry, University of Granada, 18071, Granada, Spain

    María de la Luz Cádiz-Gurrea & Antonio Segura Carretero

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  1. Mansoureh Tavan
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  2. Parichehr Hanachi
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  3. María de la Luz Cádiz-Gurrea
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  4. Antonio Segura Carretero
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  5. Mohammad Hossein Mirjalili
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ASC and MT contributed to conceptualization. MT wrote the first draft. PH, MHM, and MdlLCG contributed to the review and editing of the manuscript. All authors have read and approved the final manuscript.

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Tavan, M., Hanachi, P., de la Luz Cádiz-Gurrea, M. et al. Natural Phenolic Compounds with Neuroprotective Effects. Neurochem Res 49, 306–326 (2024). https://doi.org/10.1007/s11064-023-04046-z

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