Abstract
In the course of finding Korean natural products with acetylcholinesterase (AChE) inhibitory activity, we found that a methanolic extract of the twigs ofVaccinium oldhami significantly inhibited AChE. Bioassay-guided fractionation of the methanolic extract resulted in the isolation of two compounds, taraxerol (1) and scopoletin (2), as active constituents. These compounds inhibited AChE activity in a dose-dependent manner, and the IC50 values of compounds1 and2 were 33.6 (79 μM) and 10.0 (52 μM) μg/mL, respectively.
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Lee, J.H., Lee, K.T., Yang, J.H. et al. Acetylcholinesterase inhibitors from the twigs ofvaccinium oldhami miquel. Arch Pharm Res 27, 53–56 (2004). https://doi.org/10.1007/BF02980046
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DOI: https://doi.org/10.1007/BF02980046