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High Expression of LncRNA XIST as an Index Helping to Diagnose Parkinson’s Disease

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Neurophysiology Aims and scope

LncRNA XIST plays roles in the development of such degenerative disorder as Parkinson’s disease (PD). We herein explored its diagnostic value. Clinical baseline data (age, sex, BMI, years of education, and PD family history) of PD patients and healthy controls, as well as the diseases course in PD patients, were recorded. The PD patients were staged using the Hoehn and Yahr grading scale. Case severity, serum XIST level, correlation between the serum XIST level and UPDRS score, and XIST diagnostic value for PD were assessed by means of UPDRS score, RT-qPCR, Pearson analysis, and plotting an operating characteristic (ROC) curve. The PD patients and healthy controls presented no significant differences in age, sex, BMI, and years of education, but there were more cases with a family history of PD in PD patients. The serum XIST expression was noticeably greater in PD patients, and a higher PD stage was linked to a higher serum XIST expression. There was a positive correlation between the serum XIST expression and UPDRS score in PD patients. Thus, the XIST expression has a noticeable diagnostic value for PD.

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Authors and Affiliations

  1. Department of Neurology, Jingzhou Central Hospital (Jingzhou Hospital Affiliated to Yangtze University), Jingzhou, Hubei, China

    L. Zhang, G. Li, D. Lu & Q. Dai

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  1. L. Zhang
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  2. G. Li
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  3. D. Lu
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  4. Q. Dai
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Correspondence to Q. Dai.

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Zhang, L., Li, G., Lu, D. et al. High Expression of LncRNA XIST as an Index Helping to Diagnose Parkinson’s Disease. Neurophysiology 54, 37–42 (2022). https://doi.org/10.1007/s11062-023-09933-3

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