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Toward improvements for carrying capacity of the cyclodextrin-based nanosponges: recent progress from a material and drug delivery

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Abstract

Cyclodextrins are a type of natural materials that can be used in the pharmaceutical industry. Cyclodextrins are safe, biodegradable, with the multifunctional property as they can encapsulate both hydrophilic and hydrophobic drugs. Additionally, they can overcome challenges associated with drug toxicity and enhancing the solubility of the insoluble drugs; thus, cyclodextrins are effective carriers in loading tiny molecules. Moreover, the synthesis of nanosponges (NPs) systems can enhance the drug encapsulation in cyclodextrin cavities to control the rate of drug released. Cyclodextrin can contain the drug molecules to form a clathrate; cyclodextrin-based NPs can maintain a high loading capacity of various small molecules for drug delivery. This review presents a general overview of the current research progress and the applications of cyclodextrin-based NPs for drug delivery in the past two decades.

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Abbreviations

NPs:

Nanosponges

AGU:

Anhydrous α-D-glucopyranoside units

CD:

Cyclodextrin

HP-β-CDs:

Hydroxypropyl-β-cyclodextrins

Da:

Dalton

FT-IR:

Fourier transform infrared spectroscopy

SS-NMR:

Solid-state nuclear magnetic resonance spectrometer

DMSO:

Dimethylsulfoxide

DMF:

Dimethylformamide

TEL:

Telmisartan

HCl:

Hydrochloric

NaHCO3 :

Sodium bicarbonate

BPDMA:

Benzoporphyrin-derivative monoacid ring A

atRA:

All-trans retinoic acid

L-DOPA:

Levodopa

DSC:

Differential scanning calorimetry

XRD:

X-ray diffraction

CP:

Clobetasol propionate

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Acknowledgements

This study was funded by the National Key R&D Program of China (2018YFE0110200), the Natural Science Foundation of Hunan Province of China (2020JJ4278, 2020JJ5127, and 2018JJ4061), the key program of Hunan Provincial Department of science and technology (2020WK2020 and 2019NK2111), Program for Science & Technology Innovation Platform/Talents of Hunan Province (2019TP1029), the Scientific Research Fund of Hunan Provincial Education Department (18B290), and Zhuzhou Key Science & Technology Program of Hunan Province (2017, 2018, and 2019).

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Authors and Affiliations

  1. National Engineering Laboratory for Deep Process of Rice and Byproducts, Hunan Province Key Laboratory of Edible Forestry Resources Safety and Processing Utilization, Hunan Key Laboratory of Processed Food for Special Medical Purpose, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha, 410004, Hunan, China

    Jing Deng, Wen Li, Qin Lu Lin, Jia Li Ren & Fei Jun Luo

  2. College of Packaging and Material Engineering, College of Life Sciences and Chemistry, Hunan University of Technology, Zhuzhou, 412007, Hunan, China

    Jing Deng, Qi Jue Chen, Wen Li, Jian Xiang Feng, Quan Ming Ding, Xiao Xi Zeng, Liang Ma & Xiang Min Zheng

  3. Department of Science and Laboratory Technology, Dar es Salaam Institute of Technology, P.O. Box 2958, Dar es Salaam, Tanzania

    Zavuga Zuberi

  4. School of Resource Processing and Bioengineering, Central South University, Changsha, 410083, Hunan, China

    Hua Qun Yin

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  1. Jing Deng
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  2. Qi Jue Chen
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  3. Wen Li
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Contributions

JD, QJC, and WL conceived the paper; QJC, ZZ, JXF, QLL, QMD, XXZ, LM, JLR, FJL, HQY, and XMZ wrote the first draft; all the authors contributed substantially to the final text, tables, figure, and references to the paper.

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Correspondence to Wen Li.

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Deng, J., Chen, Q.J., Li, W. et al. Toward improvements for carrying capacity of the cyclodextrin-based nanosponges: recent progress from a material and drug delivery. J Mater Sci 56, 5995–6015 (2021). https://doi.org/10.1007/s10853-020-05646-8

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  • DOI: https://doi.org/10.1007/s10853-020-05646-8

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