Abstract
Central nervous system injuries and diseases, such as ischemic stroke, spinal cord injury, neurodegenerative diseases, glioblastoma, multiple sclerosis, and the resulting neuroinflammation often lead to death or long-term disability. MicroRNAs are small, non-coding, single-stranded RNAs that regulate posttranscriptional gene expression in both physiological and pathological cellular processes, including central nervous system injuries and disorders. Studies on miR-124, one of the most abundant microRNAs in the central nervous system, have shown that its dysregulation is related to the occurrence and development of pathology within the central nervous system. Herein, we review the molecular regulatory functions, underlying mechanisms, and effective delivery methods of miR-124 in the central nervous system, where it is involved in pathological conditions. The review also provides novel insights into the therapeutic target potential of miR-124 in the treatment of human central nervous system injuries or diseases.
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Abbreviations
- AAV:
-
Adeno-associated viruses
- Aβ:
-
β-Amyloid
- AD:
-
Alzheimer’s disease
- ALS:
-
Amyotrophic lateral sclerosis
- AMO:
-
Anti-miRNA oligonucleotide
- ANXA5:
-
AnnexinA5
- APP:
-
Amyloid precursor protein
- BBB:
-
Blood–brain barrier
- CDK:
-
Cyclin-dependent kinase
- CNS:
-
Central nervous system
- DA:
-
Dopaminergic
- DAPK1:
-
Death-associated protein kinase 1
- EAE:
-
Experimental autoimmune encephalomyelitis
- EV:
-
Extracellular vesicle
- GBM:
-
Glioblastoma
- ICH:
-
Intracerebral hemorrhage
- ITR:
-
Inverted terminal repeat elements
- LPS:
-
Lipopolysaccharide
- MCAO:
-
Middle cerebral artery occlusion
- miRNA:
-
microRNA
- MPTP:
-
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
- MS:
-
Multiple sclerosis
- NDDs:
-
Neurodegenerative diseases
- NSC:
-
Neuronal stem cells
- OGD:
-
Oxygen–glucose deprivation
- ORF:
-
Open reading frame
- PD:
-
Parkinson’s disease
- RISC:
-
RNA-induced silencing complex
- ROS:
-
Reactive oxygen species
- SCI:
-
Spinal cord injury
- STAT3:
-
Signal transducer and activator of transcription 3
- TACE:
-
TNF-α converting enzyme
- Th:
-
T helper
- VEGF:
-
Vascular endothelial growth factor
- WHO:
-
World Health Organization
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The authors would like to thank Editage (www.editage.cn) for English language editing.
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This work was supported by the National Natural Science Foundation of China [#81571199]; the National Natural Science Foundation of China [#81870974]; and the Fundamental Research Funds for the Central Universities, JLU.
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JX and YZ conceived this review article and participated in preparing all drafts of the manuscript. LW, YL, and XW participated in part of the original draft preparation, and final editing and approval of the final draft was performed by YL and GC. All the authors read the article and approved the final version.
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Xu, J., Zheng, Y., Wang, L. et al. miR-124: A Promising Therapeutic Target for Central Nervous System Injuries and Diseases. Cell Mol Neurobiol 42, 2031–2053 (2022). https://doi.org/10.1007/s10571-021-01091-6
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DOI: https://doi.org/10.1007/s10571-021-01091-6