Abstract
Food nanotechnology has been rapidly growing in last decade due to the unique properties of nanomaterials. Nonetheless, the presence of nanomaterials in food induces potential risks of toxicity because nanoparticles can easily cross the barriers of human anatomy, through respiratory, dermal, and gastrointestinal routes. In that respect, some countries such as India do not have strict regulations to control nanofood products. This review describes nanomaterial–cell interactions that induce toxicological responses. We discuss the toxicity of food nanomaterials; mechanisms of oxidative stress, genotoxicity and carcinogenicity; and safety regulations.
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References
Albanese A, Chan WCW (2011) Effect of gold nanoparticle aggregation on cell uptake and toxicity. In: ACS nano, pp 5478–5489
Alsaleh NB, Brown JM (2018) Immune responses to engineered nanomaterials: current understanding and challenges. Curr Opin Toxicol 10:8–14. https://doi.org/10.1016/j.cotox.2017.11.011
Amenta V, Aschberger K, Arena M et al (2015) Regulatory aspects of nanotechnology in the agri/feed/food sector in EU and non-EU countries. Regul Toxicol Pharmacol 73:463–476. https://doi.org/10.1016/j.yrtph.2015.06.016
Ames BN, McCann J, Yamasaki E (1975) Methods for detecting carcinogens and mutagens with the salmonella/mammalian-microsome mutagenicity test. Mutat Res Mutagen Relat Subj 31:347–363. https://doi.org/10.1016/0165-1161(75)90046-1
An H, Liu Q, Ji Q, Jin B (2010) DNA binding and aggregation by carbon nanoparticles. Biochem Biophys Res Commun 393:571–576. https://doi.org/10.1016/j.bbrc.2010.02.006
Asare N, Instanes C, Sandberg WJ et al (2012) Cytotoxic and genotoxic effects of silver nanoparticles in testicular cells. Toxicology 291:65–72. https://doi.org/10.1016/j.tox.2011.10.022
Ashutosh K, Alok D (2013a) Manual on critical issues in nanotechnology R&D management: an Asia-Pacific perspective—Chapter 1—nano-safety, standardization and certification, pp 1–40
Ashutosh K, Alok D (2013b) Genotoxic and carcinogenic potential of engineered nanoparticles: an update. Arch Toxicol 87:1883–1900
Ashutosh K, Najafzadeh M, Jacob BK et al (2015) Zinc oxide nanoparticles affect the expression of p53, Ras p21 and JNKs: an ex vivo/in vitro exposure study in respiratory disease patients. Mutagenesis 30:237–245. https://doi.org/10.1093/mutage/geu064
Bakand S, Hayes A, Dechsakulthorn F (2012) Nanoparticles: a review of particle toxicology following inhalation exposure. Inhal Toxicol 24:125–135
Baltic ZM, Boskovic M, Ivanovic J, Dokmanovic M, Janjic J, Loncina JBT (2013) Nanotechnology and its potential applications in meat industry. Tehn Mesa 54(2):168–175
Barnes CA, Elsaesser A, Arkusz J et al (2008) Reproducible comet assay of amorphous silica nanoparticles detects no genotoxicity. Nano Lett 8:3069–3074. https://doi.org/10.1021/nl801661w
Baweja L, Gurbani D, Shanker R et al (2011) C60-fullerene binds with the ATP binding domain of human DNA topoiosmerase II alpha. J Biomed Nanotechnol 7:177–178
Benyamini H, Shulman-Peleg A, Wolfson HJ et al (2006) Interaction of C60-fullerene and carboxyfullerene with proteins: docking and binding site alignment. Bioconjug Chem 17:378–386. https://doi.org/10.1021/bc050299g
Bergamaschi E, Bussolati O, Magrini A et al (2006) Nanomaterials and lung toxicity: interactions with airways cells and relevance for occupational health risk assessment. Int J Immunopathol Pharmacol 19:3–10
Böckmann J, Lahl H, Eckert T, Unterhalt B (2000) Blood titanium levels before and after oral administration titanium dioxide. Pharmazie 55:140–143
Borm PJA, Kreyling W (2004) Toxicological hazards of inhaled nanoparticles–potential implications for drug delivery. J Nanosci Nanotechnol 4:521–531. https://doi.org/10.1166/jnn.2004.081
Boussaad S, Diner B, Fan J, Rostovtsev V (2006) Redox potential mediated carbon nanotubes biosensing in homogeneous format. WO2006137899
Bouwmeester H, Dekkers S, Noordam MY et al (2009) Review of health safety aspects of nanotechnologies in food production. Regul Toxicol Pharmacol 53:52–62. https://doi.org/10.1016/j.yrtph.2008.10.008
Cadenas E, Davies KJ (2000) Mitochondrial free radical generation, oxidative stress, and aging. Free Radic Biol Med 29:222–230. https://doi.org/10.1016/S0891-5849(00)00317-8
Chan GH, Zhao J, Schatz GC, Van Duyne RP (2008) Localized surface plasmon resonance spectroscopy of triangular aluminum nanoparticles. J Phys Chem C 112:13958–13963. https://doi.org/10.1021/jp804088z
Chen Z, Wang Y, Ba T et al (2014) Genotoxic evaluation of titanium dioxide nanoparticles in vivo and in vitro. Toxicol Lett 226:314–319. https://doi.org/10.1016/j.toxlet.2014.02.020
Crosera M, Bovenzi M, Maina G et al (2009) Nanoparticle dermal absorption and toxicity: a review of the literature. Int Arch Occup Environ Health 82:1043–1055
Danie Kingsley J, Ranjan S, Dasgupta N, Saha P (2013) Nanotechnology for tissue engineering: need, techniques and applications. J Pharm Res 7:200–204. https://doi.org/10.1016/j.jopr.2013.02.021
Dasgupta N, Ranjan S (2018) Nano-food toxicity and regulations. In: An introduction to food grade nanoemulsions. Springer, Singapore, pp 151–179. https://doi.org/10.1007/978-981-10-6986-4_9
Dasgupta N, Ranjan S, Mundekkad D et al (2015) Nanotechnology in agro-food: from field to plate. Food Res Int 69:381–400
Dasgupta N, Ranjan S, Mundra S et al (2016a) Fabrication of food grade vitamin E nanoemulsion by low energy approach, characterization and its application. Int J Food Prop 19:700–708. https://doi.org/10.1080/10942912.2015.1042587
Dasgupta N, Ranjan S, Rajendran B et al (2016b) Thermal co-reduction approach to vary size of silver nanoparticle: its microbial and cellular toxicology. Environ Sci Pollut Res 23:4149–4163. https://doi.org/10.1007/s11356-015-4570-z
Decision C (2004) (Text with EEA relevance). Euratom 2001, pp 20–30. http://eur-lex.europa.eu/pri/en/oj/dat/2003/l_285/l_28520031101en00330037.pdf
Dhawan A, Sharma V (2010) Toxicity assessment of nanomaterials: methods and challenges. Anal Bioanal Chem 398:589–605. https://doi.org/10.1007/s00216-010-3996-x
Dhawan A, Sharma V, Parmar D (2009) Nanomaterials: a challenge for toxicologists. Nanotoxicology 3:1–9. https://doi.org/10.1080/17435390802578595
Dhawan A, Shanker R, Das M, Gupta KC (2011) Guidance for safe handling of nanomaterials. J Biomed Nanotechnol 7:218–224
Dobrzyńska MM, Gajowik A, Radzikowska J et al (2014) Genotoxicity of silver and titanium dioxide nanoparticles in bone marrow cells of rats in vivo. Toxicology 315:86–91. https://doi.org/10.1016/j.tox.2013.11.012
Dockery DW, Pope CA, Xu X et al (1993) An association between air pollution and mortality in six U.S. cities. N Engl J Med 329:1753–1759. https://doi.org/10.1097/00043764-199502000-00008
dos Santos DCM, de Souza MLS, Teixeira EM et al (2018) A new nanoemulsion formulation improves antileishmanial activity and reduces toxicity of amphotericin B. J Drug Target 26:357–364. https://doi.org/10.1080/1061186X.2017.1387787
Elder A, Lynch I, Grieger KD et al (2009) Human health risks of engineered nanomaterials: Critical knowledge gaps in nanomaterials risk assessment. In: Linkov I, Steevens J (eds) Nanotechnology. Risks and benefits. Springer, Dordrecht, NL, pp 3–29
Fadeel B, Garcia-Bennett AE (2010) Better safe than sorry: understanding the toxicological properties of inorganic nanoparticles manufactured for biomedical applications. Adv Drug Deliv Rev 62:362–374
Ferin J, Oberdörster G, Penney DP (1992) Pulmonary retention of ultrafine and fine particles in rats. Am J Respir Cell Mol Biol 6:535–542. https://doi.org/10.1165/ajrcmb/6.5.535
Gorain B, Choudhury H, Tekade RK et al (2016) Comparative biodistribution and safety profiling of olmesartan medoxomil oil-in-water oral nanoemulsion. Regul Toxicol Pharmacol 82:20–31. https://doi.org/10.1016/j.yrtph.2016.10.020
Guo Y-Y, Zhang J, Zheng Y-F et al (2011) Cytotoxic and genotoxic effects of multi-wall carbon nanotubes on human umbilical vein endothelial cells in vitro. Mutat Res 721:184–191. https://doi.org/10.1016/j.mrgentox.2011.01.014
He Q, Yuan W, Liu J, Zhang Z (2008) Study on in vivo distribution of liver-targeting nanopaticles encapsulating thymidine kinase gene (TK gene) in mice. J Mater Sci Mater Med 19:559–565. https://doi.org/10.1007/s10856-007-3182-7
Heinemann M, Schäfer HG (2009) Guidance for handling and use of nanomaterials at the workplace. Hum Exp Toxicol 28:407–411. https://doi.org/10.1177/0960327109105149
Heng BC, Zhao X, Tan EC et al (2011) Evaluation of the cytotoxic and inflammatory potential of differentially shaped zinc oxide nanoparticles. Arch Toxicol 85:1517–1528. https://doi.org/10.1007/s00204-011-0722-1
Hirose A (2013) International trend of guidance for nanomaterial risk assessment. Yakugaku Zasshi 133:175–180. https://doi.org/10.1248/yakushi.12-00244-4
Huang J, Li Q, Sun D et al (2007) Biosynthesis of silver and gold nanoparticles by novel sundried Cinnamomum camphora leaf. Nanotechnology 18:105104. https://doi.org/10.1088/0957-4484/18/10/105104
Ismail IH, Wadhra TI, Hammarsten O (2007) An optimized method for detecting gamma-H2AX in blood cells reveals a significant interindividual variation in the gamma-H2AX response among humans. Nucleic Acids Res. https://doi.org/10.1093/nar/gkl1169
Jain A, Ranjan S, Dasgupta N, Ramalingam C (2017) Nanomaterials in food and agriculture: an overview on their safety concerns and regulatory issues. Crit Rev Food Sci Nutr 58(2):297–317. https://doi.org/10.1080/10408398.2016.1160363
Jani P, Halbert GW, Langridge J, Florence AT (1990) Nanoparticle uptake by the rat gastrointestinal mucosa: quantitation and particle size dependency. J Pharm Pharmacol 42:821–826. https://doi.org/10.1111/j.2042-7158.1990.tb07033.x
Jasmine L, Muralikrishnan S, Ng C-T et al (2010) Nanoparticle-induced pulmonary toxicity. Exp Biol Med 235:1025–1033. https://doi.org/10.1258/ebm.2010.010021
Jin P, Chen Y, Zhang S, Chen Z (2012) Interactions between Al12X (X = Al, C, N and P) nanoparticles and DNA nucleobases/base pairs: implications for nanotoxicity. J Mol Model 18:559–568. https://doi.org/10.1007/s00894-011-1085-5
Joe MM, Chauhan PS, Bradeeba K et al (2012) Influence of sunflower oil based nanoemulsion (AUSN-4) on the shelf life and quality of Indo-Pacific king mackerel (Scomberomorus guttatus) steaks stored at 20 °C. Food Control 23:564–570. https://doi.org/10.1016/j.foodcont.2011.08.032
Johnson MM, Mendoza R, Raghavendra AJ et al (2017) Contribution of engineered nanomaterials physicochemical properties to mast cell degranulation. Sci Rep 7:43570
Jones CF, Grainger DW (2009) In vitro assessments of nanomaterial toxicity. Adv Drug Deliv Rev 61:438–456
Jugan M-L, Barillet S, Simon-Deckers A et al (2012) Titanium dioxide nanoparticles exhibit genotoxicity and impair DNA repair activity in A549 cells. Nanotoxicology 6:501–513
Kain J, Karlsson HL, Möller L (2012) DNA damage induced by micro- and nanoparticles–interaction with FPG influences the detection of DNA oxidation in the comet assay. Mutagenesis 27:491–500. https://doi.org/10.1093/mutage/ges010
Kalpana Sastry R, Anshul S, Rao NH (2013) Nanotechnology in food processing sector—an assessment of emerging trends. J Food Sci Technol 50:831–841
Kalpana S, Rashmi HB, Rao NH (2010) Nanotechnology patents as R&D indicators for disease management strategies in agriculture. J Intellect Prop Rights 15:197–205
Kansara K, Patel P, Shah D et al (2014) TiO2 nanoparticles induce cytotoxicity and genotoxicity in human alveolar cells. Mol Cytogenet 7:P77. https://doi.org/10.1186/1755-8166-7-S1-P77
Kansara K, Patel P, Shah D et al (2015) TiO2 nanoparticles induce DNA double strand breaks and cell cycle arrest in human alveolar cells. Environ Mol Mutagen 56:204–217. https://doi.org/10.1002/em.21925
Karlsson HL, Gustafsson J, Cronholm P, Möller L (2009) Size-dependent toxicity of metal oxide particles—a comparison between nano- and micrometer size. Toxicol Lett 188:112–118. https://doi.org/10.1016/j.toxlet.2009.03.014
Khan MI, Mohammad A, Patil G et al (2012) Induction of ROS, mitochondrial damage and autophagy in lung epithelial cancer cells by iron oxide nanoparticles. Biomaterials 33:1477–1488. https://doi.org/10.1016/j.biomaterials.2011.10.080
Kim EK et al (2009) Nanoparticulate-induced toxicity and related mechanism in vitro and in vivo. J Nanoparticle Res 11:55–65
Kim HR, Kim MJ, Lee SY et al (2011) Genotoxic effects of silver nanoparticles stimulated by oxidative stress in human normal bronchial epithelial (BEAS-2B) cells. Mutat Res 726:129–135. https://doi.org/10.1016/j.mrgentox.2011.08.008
Kisin ER, Murray AR, Keane MJ et al (2007) Single-walled carbon nanotubes: geno- and cytotoxic effects in lung fibroblast V79 cells. J Toxicol Environ Health A 70:2071–2079. https://doi.org/10.1080/15287390701601251
Kumar A, Pandey AK, Singh SS et al (2011a) Engineered ZnO and TiO2 nanoparticles induce oxidative stress and DNA damage leading to reduced viability of Escherichia coli. Free Radic Biol Med 51:1872–1881. https://doi.org/10.1016/j.freeradbiomed.2011.08.025
Kumar A, Pandey AK, Singh SS et al (2011b) Cellular uptake and mutagenic potential of metal oxide nanoparticles in bacterial cells. Chemosphere 83:1124–1132. https://doi.org/10.1016/j.chemosphere.2011.01.025
Kumar A, Kumar P, Anandan A et al (2014) Engineered nanomaterials: knowledge gaps in fate, exposure, toxicity, and future directions. J Nanomater. https://www.hindawi.com/journals/jnm/2014/130198/
Künzli N, Tager IB (2005) Air pollution: from lung to heart. Swiss Med Wkly 135:697–702
Lamprecht A, Yamamoto H, Takeuchi H, Kawashima Y (2004) Design of pH-sensitive microspheres for the colonic delivery of the immunosuppressive drug tacrolimus. Eur J Pharm Biopharm 58:37–43
Lane KE, Li W, Smith C, Derbyshire E (2014) The bioavailability of an omega-3-rich algal oil is improved by nanoemulsion technology using yogurt as a food vehicle. Int J Food Sci Technol 49:1264–1271. https://doi.org/10.1111/ijfs.12455
Lewis DJ, Bruce C, Bohic S et al (2010) Intracellular synchrotron nanoimaging and DNA damage/genotoxicity screening of novel lanthanide-coated nanovectors. Nanomedicine 5:1547–1557. https://doi.org/10.2217/nnm.10.96
Li Y, Chen DH, Yan J et al (2012) Genotoxicity of silver nanoparticles evaluated using the Ames test and in vitro micronucleus assay. Mutat Res Toxicol Environ Mutagen 745:4–10. https://doi.org/10.1016/j.mrgentox.2011.11.010
Love SA, Maurer-Jones MA, Thompson JW et al (2012) Assessing nanoparticle toxicity. Annu Rev Anal Chem 5:181–205
Luo C, Urgard E, Vooder T, Metspalu A (2011) The role of COX-2 and Nrf2/ARE in anti-inflammation and antioxidative stress: aging and anti-aging. Med Hypotheses 77:174–178. https://doi.org/10.1016/j.mehy.2011.04.002
Maenosono S, Yoshida R, Saita S (2009) Evaluation of genotoxicity of amine-terminated water-dispersible FePt nanoparticles in the Ames test and in vitro chromosomal aberration test. J Toxicol Sci 34:349–354
Magdolenova Z, Collins A, Kumar A et al (2014) Mechanisms of genotoxicity. A review of in vitro and in vivo studies with engineered nanoparticles. Nanotoxicology 8:233–278. https://doi.org/10.3109/17435390.2013.773464
Marrani D (2013) Nanotechnologies and novel foods in European law. Nanoethics 7:177–188. https://doi.org/10.1007/s11569-013-0176-4
Maynard AD, Warheit DB, Philbert MA (2011) The new toxicology of sophisticated materials: nanotoxicology and beyond. Toxicol Sci 120:S109–S129
Md S, Gan SY, Haw YH et al (2018) In vitro neuroprotective effects of naringenin nanoemulsion against β-amyloid toxicity through the regulation of amyloidogenesis and tau phosphorylation. Int J Biol Macromol 118:1211–1219. https://doi.org/10.1016/j.ijbiomac.2018.06.190
Melo KM, Fascineli ML, Milhomem-Paixão SSR et al (2018) Evaluation of the genotoxic and antigenotoxic effects of andiroba (Carapa guianensis Aublet) oil and nanoemulsion on swiss mice. J Nanomater 1:1. https://doi.org/10.1155/2018/4706057
Mihranyan A, Ferraz N, Stromme M (2012) Current status and future prospects of nanotechnology in cosmetics. Prog Mater Sci 57:875–910
Mishra P, Balaji APB, Mukherjee A (2018) Bio-based nanoemulsions: an eco-safe approach towards the eco-toxicity problem. Springer, Berlin, pp 1–23
Mortelmans K, Zeiger E (2000) The Ames Salmonella/microsome mutagenicity assay. Mutat Res Mol Mech Mutagen 455:29–60. https://doi.org/10.1016/S0027-5107(00)00064-6
Mossa AH, Afia SI, Mohafrash SMM, Abou-awad BA (2018) Formulation and characterization of garlic (Allium sativum L.) essential oil nanoemulsion and its acaricidal activity on eriophyid olive mites (Acari: Eriophyidae). Environ Sci Pollut Res 25:10526–10537
Musazzi UM, Franzè S, Minghetti P, Casiraghi A (2018) Emulsion versus nanoemulsion: how much is the formulative shift critical for a cosmetic product? Drug Deliv Transl Res 8:414–421. https://doi.org/10.1007/s13346-017-0390-7
Nanoemulsion P, Tao R, Wang C et al (2018) Characterization, cytotoxicity, and genotoxicity of TiO2 and folate-coupled chitosan nanoparticles loading. Biol Trace Elem Res 184:60–74
Noori S, Zeynali F, Almasi H (2018) Antimicrobial and antioxidant efficiency of nanoemulsion-based edible coating containing ginger (Zingiber officinale) essential oil and its effect on safety and quality attributes of chicken breast fillets. Food Control 84:312–320. https://doi.org/10.1016/j.foodcont.2017.08.015
Oberdörster G, Oberdörster E, Oberdörster J (2005) Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 113:823–839
Pietroiusti A, Campagnolo L, Fadeel B (2013) Interactions of engineered nanoparticles with organs protected by internal biological barriers. Small 9:1557–1572
Ranjan S, Dasgupta N, Chakraborty AR et al (2014) Nanoscience and nanotechnologies in food industries: opportunities and research trends. J Nanoparticle Res 16:1–23. https://doi.org/10.1007/s11051-014-2464-5
Rico CM, Majumdar S, Duarte-Gardea M et al (2011) Interaction of nanoparticles with edible plants and their possible implications in the food chain. J Agric Food Chem 59:3485–3498
Saratale RG, Lee HS, Koo YE et al (2018) Absorption kinetics of vitamin E nanoemulsion and green tea microstructures by intestinal in situ single perfusion technique in rats. Food Res Int 106:149–155. https://doi.org/10.1016/j.foodres.2017.12.076
Savolainen K, Alenius H, Norppa H et al (2010) Risk assessment of engineered nanomaterials and nanotechnologies—a review. Toxicology 269:92–104
Schwartz J (1994) Air pollution and daily mortality: a review and meta analysis. Environ Res 64:36–52. https://doi.org/10.1006/enrs.1994.1005
Scott-Fordsmand JJ, Peijnenburg WJGM, Semenzin E et al (2017) Environmental risk assessment strategy for nanomaterials. Int J Environ Res Public Health 14:1251
Shannahan JH, Podila R, Brown JM (2015) A hyperspectral and toxicological analysis of protein corona impact on silver nanoparticle properties, intracellular modifications, and macrophage activation. Int J Nanomed 10:6509–6521
Shannahan JH, Fritz KS, Raghavendra AJ et al (2016) From the cover: disease-induced disparities in formation of the nanoparticle-biocorona and the toxicological consequences. Toxicol Sci 152:406–416
Sharma V, Anderson D, Dhawan A (2012a) Zinc oxide nanoparticles induce oxidative DNA damage and ROS-triggered mitochondria mediated apoptosis in human liver cells (HepG2). Apoptosis 17:852–870. https://doi.org/10.1007/s10495-012-0705-6
Sharma V, Kumar A, Dhawan A (2012b) Nanomaterials: exposure, effects and toxicity assessment. Proc Natl Acad Sci India Sect B Biol Sci 82:3–11. https://doi.org/10.1007/s40011-012-0072-7
Shinohara N, Matsumoto K, Endoh S et al (2009) In vitro and in vivo genotoxicity tests on fullerene C60 nanoparticles. Toxicol Lett 191:289–296. https://doi.org/10.1016/j.toxlet.2009.09.012
Shivendu R, Nandita D (2013) Proposal grant “NanoToF: toxicological evaluation for nanoparticles used in food”. PI: Dr. C. Ramalingam, Co-PI: Dr. Ashutosh K and Dr. Ramanathan K
Shukla RK, Sharma V, Pandey AK et al (2011) ROS-mediated genotoxicity induced by titanium dioxide nanoparticles in human epidermal cells. Toxicol In Vitro 25:231–241. https://doi.org/10.1016/j.tiv.2010.11.008
Shukla RK, Kumar A, Gurbani D et al (2013) TiO2 nanoparticles induce oxidative DNA damage and apoptosis in human liver cells. Nanotoxicology 7:48–60. https://doi.org/10.3109/17435390.2011.629747
Shukla RK, Kumar A, Vallabani NVS et al (2014) Titanium dioxide nanoparticle-induced oxidative stress triggers DNA damage and hepatic injury in mice. Nanomedicine (Lond). https://doi.org/10.2217/nnm.13.100
Silvestre C, Duraccio D, Cimmino S (2011) Food packaging based on polymer nanomaterials. Prog Polym Sci 36:1766–1782. https://doi.org/10.1016/j.progpolymsci.2011.02.003
Sodano V, Gorgitano MT, Quaglietta M, Verneau F (2016) Regulating food nanotechnologies in the European Union: open issues and political challenges. Trends Food Sci Technol 54:216–226
Sotto DA, Chiaretti M, Carru GA et al (2009) Multi-walled carbon nanotubes: lack of mutagenic activity in the bacterial reverse mutation assay. Toxicol Lett 184:192–197. https://doi.org/10.1016/j.toxlet.2008.11.007
Stone V, Johnston H, Schins RPF (2009) Development of in vitro systems for nanotoxicology: methodological considerations. Crit Rev Toxicol 39:613–626. https://doi.org/10.1080/10408440903120975
Stratakos AC, Grant IR (2018) Evaluation of the efficacy of multiple physical, biological and natural antimicrobial interventions for control of pathogenic Escherichia coli on beef. Food Microbiol 76:209–218. https://doi.org/10.1016/j.fm.2018.05.011
Sugumaran A, Ponnusamy C, Kandasamy P (2018) European Journal of Pharmaceutical Sciences Development and evaluation of camptothecin loaded polymer stabilized nanoemulsion: targeting potential in 4T1-breast tumour xenograft model. Eur J Pharm Sci 116:15–25. https://doi.org/10.1016/j.ejps.2017.10.005
T E R I Report No. 2006ST21: D6 (2009) Regulatory challenges posed by nanotechnology developments in India. New Delhi
Tervonen T, Linkov I, Figueira JR et al (2009) Risk-based classification system of nanomaterials. J Nanoparticle Res 11:757–766. https://doi.org/10.1007/s11051-008-9546-1
Villena de Francisco E, García-Estepa RM (2018) Nanotechnology in the agrofood industry. J Food Eng 238:1–11. https://doi.org/10.1016/j.jfoodeng.2018.05.024
Wang D, Sun L, Liu W et al (2009) Photoinduced DNA cleavage by alpha-, beta-, and gamma-cyclodextrin-bicapped C60 supramolecular complexes. Environ Sci Technol 43:5825–5829
Wani TA, Masoodi FA, Jafari SM, David J (2018) Safety of nanoemulsions and their regulatory status. Elsevier, Amsterdam
Wu YL, Putcha N, Ng KW et al (2013) Biophysical responses upon the interaction of nanomaterials with cellular interfaces. Acc Chem Res 46:782–791. https://doi.org/10.1021/ar300046u
Xie G, Sun J, ZhonG G et al (2010) Biodistribution and toxicity of intravenously administered silica nanoparticles in mice. Arch Toxicol 84:183–190. https://doi.org/10.1007/s00204-009-0488-x
Yamakoshi Y, Aroua S, Nguyen T-MD et al (2014) Water-soluble fullerene materials for bioapplications: photoinduced reactive oxygen species generation. Faraday Discuss 173:287–296. https://doi.org/10.1039/C4FD00076E
Yoon HJ, Zhang X, Kang MG et al (2018) Cytotoxicity evaluation of turmeric extract incorporated oil-in-water nanoemulsion. Int J Mol Sci 19:1–12. https://doi.org/10.3390/ijms19010280
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Ranjan, S., Dasgupta, N., Singh, S. et al. Toxicity and regulations of food nanomaterials. Environ Chem Lett 17, 929–944 (2019). https://doi.org/10.1007/s10311-018-00851-z
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DOI: https://doi.org/10.1007/s10311-018-00851-z