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Influence of Intravascular Laser Irradiation of Blood (ILIB) on inflammatory cytokines and nitric oxide in vivo: a systematic review

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Abstract

The use of Intravascular Laser Irradiation of Blood (ILIB) as a treatment or adjunct tool has been used around the world since the 1980s. So that more professionals can deliver benefits to their patients in different areas of health, it is necessary to understand in depth the mechanisms of laser action at the molecular level, for correct indication and success in the treatment. To analyze works that evaluated the influence of ILIB on inflammatory cytokines and nitric oxide (NO) in animals and humans. The literature search was carried out between February and April 2023 in Pubmed, Medline, Web of Science, SciELO, Lilacs database. The risk of bias was assessed using the bias table where the authors performed the analyzes of all articles with the risk of bias domains. The methodology was defined following the PRISMA guidelines (Preferred Systematic Reviews and MetaAnalysis Report). The search retrieved 135 possibly relevant articles. After removing duplicates, according to the eligibility criteria, evaluation of titles and review of abstracts, in the end, 6 articles were included. An increase in anti-inflammatory cytokines, a decrease in pro-inflammatory cytokines and an increase in NO can be observed. The wavelengths used ranged from 660 to 808 nm when using a low intensity laser and when using a VIP light source 480–3400 nm, they also differed in terms of the light emission pattern. ILIB may be a complementary treatment option for patients who have comorbidities that lead to systemic inflammation.

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Authors and Affiliations

  1. Department of Clinical Oncology, Stem Cells and Cell Therapy, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil

    Milena Rodrigues Vasconcelos

  2. Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil

    Lana Cardoso-Silva & Maria Cristina Borsatto

  3. Department of Periodontics, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil

    Ana Carolina Loyola Barbosa

  4. Department of Restorative Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil

    Silmara Aparecida Milori Corona

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  1. Milena Rodrigues Vasconcelos
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  2. Lana Cardoso-Silva
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  3. Ana Carolina Loyola Barbosa
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  4. Maria Cristina Borsatto
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Vasconcelos, M.R., Cardoso-Silva, L., Barbosa, A.C.L. et al. Influence of Intravascular Laser Irradiation of Blood (ILIB) on inflammatory cytokines and nitric oxide in vivo: a systematic review. Lasers Med Sci 39, 85 (2024). https://doi.org/10.1007/s10103-024-04031-0

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