Abstract
Purpose
Secondary hip osteoarthritis after acetabular fractures requiring total arthroplasty (THA) poses a huge burden on the affected patients as well as health systems. The present study aimed to assess risk factors associated with THA after acetabular fractures based on the data from the German Pelvic Trauma Registry.
Methods
Retrospective analysis of 678 acetabular fracture cases without concomitant pelvic ring fracture treated and followed-up between January 2004 and May 2015 at six large trauma centres. Multivariate Cox regression analysis was performed assessing the association of patient/treatment characteristics with THA likelihood at an average follow-up of 2.7 years (range 0.4–9.5 years; SD 1.8 years).
Results
Overall, the rate of secondary osteoarthritis was 19.8%. The likelihood for THA increased with 6% per age year (95% CI 1.04–1.09) and with 21% per millimetre subluxation (95%CI 1.09–1.33). This likelihood was 3.54 (95% CI 1.77–7.08) and 3.68 times (95% CI 1.87–7.47) higher if the posterior wall was involved and a contusion and/or impaction of the femoral head was present. Other covariates (sex, ISS, trauma type, AO/OTA and Letournel classification, initial displacement, surgical approach, intra-articular fragments, contusion and/or impaction to the acetabulum, reduction, intervention type, duration of surgery, soft tissue damage, residual fracture step/gap, and prevention of heterotopic ossifications) were not significantly associated (p > 0.15).
Conclusions
Twenty percent of patients with acetabular fractures require THA. The associated risk factors are patient age, femoral head lesion/subluxation, and involvement of the posterior wall. The identified risk factors support previous research and should be minded when treatment of acetabular fractures is planned.
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References
Nho SJ, Kymes SM, Callaghan JJ, Felson DT (2013) The burden of hip osteoarthritis in the United States: epidemiologic and economic considerations. J Am Acad Orthop Surg 21(Suppl 1):S1–S6. https://doi.org/10.5435/JAAOS-21-07-S1
Luthje P, Helkamaa T, Nurmi-Luthje I, Kaukonen JP, Kataja M (2014) An 8-year follow-up study of 221 consecutive hip fracture patients in Finland: analysis of reoperations and their direct medical costs. Scand J Surg 103(1):46–53. https://doi.org/10.1177/1457496913494726
O’Toole RV, Hui E, Chandra A, Nascone JW (2014) How often does open reduction and internal fixation of geriatric acetabular fractures lead to hip arthroplasty? J Orthop Trauma 28(3):148–153. https://doi.org/10.1097/BOT.0b013e31829c739a
Giannoudis PV, Grotz MR, Papakostidis C, Dinopoulos H (2005) Operative treatment of displaced fractures of the acetabulum. A meta-analysis. J Bone Joint Surg Br 87(1):2–9
Tannast M, Najibi S, Matta JM (2012) Two to twenty-year survivorship of the hip in 810 patients with operatively treated acetabular fractures. J Bone Joint Surg Am 94(17):1559–1567. https://doi.org/10.2106/JBJS.K.00444
Boudissa M, Ruatti S, Kerschbaumer G, Milaire M, Merloz P, Tonetti J (2016) Part 2: outcome of acetabular fractures and associated prognostic factors-a ten-year retrospective study of one hundred and fifty six operated cases with open reduction and internal fixation. Int Orthop 40(10):2151–2156. https://doi.org/10.1007/s00264-015-3070-6
Kühn K, D’Lima DD, Hashimoto S, Lotz M (2004) Cell death in cartilage. Osteoarthr Cartil 12(1):1–16. https://doi.org/10.1016/j.joca.2003.09.015
Dirschl DR, Marsh JL, Buckwalter JA, Gelberman R, Olson SA, Brown TD, Llinias A (2004) Articular fractures. J Am Acad Orthop Surg 12(6):416–423
Wassilew GI, Lehnigk U, Duda GN, Taylor WR, Matziolis G, Dynybil C (2010) The expression of proinflammatory cytokines and matrix metalloproteinases in the synovial membranes of patients with osteoarthritis compared with traumatic knee disorders. Arthroscopy 26(8):1096–1104. https://doi.org/10.1016/j.arthro.2009.12.018
Seifer DR, Furman BD, Guilak F, Olson SA, Brooks SC 3rd, Kraus VB (2008) Novel synovial fluid recovery method allows for quantification of a marker of arthritis in mice. Osteoarthritis and cartilage/OARS, Osteoarthritis Research Society 16(12):1532–1538. https://doi.org/10.1016/j.joca.2008.04.013
Martin JA, Buckwalter JA (2002) Aging, articular cartilage chondrocyte senescence and osteoarthritis. Biogerontology 3(5):257–264
Beecher BR, Martin JA, Pedersen DR, Heiner AD, Buckwalter JA (2007) Antioxidants block cyclic loading induced chondrocyte death. Iowa Orthop J 27:1–8
Buckwalter JA, Martin JA (2006) Osteoarthritis. Adv Drug Deliv Rev 58(2):150–167. https://doi.org/10.1016/j.addr.2006.01.006
Valdes AM, Doherty SA, Muir KR, Wheeler M, Maciewicz RA, Zhang W, Doherty M (2013) The genetic contribution to severe post-traumatic osteoarthritis. Ann Rheum Dis 72(10):1687–1690. https://doi.org/10.1136/annrheumdis-2012-202562
Hashimoto S, Rai MF, Janiszak KL, Cheverud JM, Sandell LJ (2012) Cartilage and bone changes during development of post-traumatic osteoarthritis in selected LGXSM recombinant inbred mice. Osteoarthritis and cartilage/OARS, Osteoarthritis Research Society 20(6):562–571. https://doi.org/10.1016/j.joca.2012.01.022
Lehmann W, Hoffmann M, Fensky F, Nuchtern J, Grossterlinden L, Aghayev E, Lehmann H, Stuby F, Rueger JM (2014) What is the frequency of nerve injuries associated with acetabular fractures? Clin Orthop Relat Res 472(11):3395–3403. https://doi.org/10.1007/s11999-014-3838-9
Hauschild O, Aghayev E, von Heyden J, Strohm PC, Culemann U, Pohlemann T, Suedkamp NP, Schmal H (2012) Angioembolization for pelvic hemorrhage control: results from the German pelvic injury register. J Trauma Acute Care Surg 73 (3):679–684. https://doi.org/10.1097/TA.0b013e318253b5ba
AO/OTA (2007) Pelvis J Orthop Trauma 21 (Suppl10) (10):S59-S67
Letournel E (1980) Acetabulum fractures: classification and management. Clin Orthop Relat Res 151:81–106
Burkhardt M, Nienaber U, Krause J, Pizanis A, Moersdorf P, Culemann U, Aghayev E, Paffrath T, Pohlemann T, Holstein JH, Beckenregister DGU, TraumaRegister DGU (2014) Complex pelvic traumas : data linkage of the German pelvic injury register and the TraumaRegister DGU(R). Unfallchirurg. https://doi.org/10.1007/s00113-014-2565-8
Bosch U, Pohlemann T, Haas N, Tscherne H (1992) Classification and management of complex pelvic trauma. Unfallchirurg 95(4):189–196
Judet R, Judet J, Letournel E (1964) Fractures of the acetabulum. Acta Orthop Belg 30:285–293
Clarke-Jenssen J, Roise O, Storeggen SAO, Madsen JE (2017) Long-term survival and risk factors for failure of the native hip joint after operatively treated displaced acetabular fractures. Bone Joint J 99-B(6):834–840. https://doi.org/10.1302/0301-620X.99B6.BJJ-2016-1013.R1
Boelch SP, Jordan MC, Meffert RH, Jansen H (2017) Comparison of open reduction and internal fixation and primary total hip replacement for osteoporotic acetabular fractures: a retrospective clinical study. Int Orthop 41(9):1831–1837. https://doi.org/10.1007/s00264-016-3260-x
Salama W, Mousa S, Khalefa A, Sleem A, Kenawey M, Ravera L, Masse A (2017) Simultaneous open reduction and internal fixation and total hip arthroplasty for the treatment of osteoporotic acetabular fractures. Int Orthop 41(1):181–189. https://doi.org/10.1007/s00264-016-3175-6
Bogdan Y, Dwivedi S, Tornetta P, 3rd (2014) A surgical approach algorithm for transverse posterior wall fractures aids in reduction quality. Clin Orthop Relat Res 472 (11):3338–3344. https://doi.org/10.1007/s11999-014-3634-6
Haidukewych GJ, Scaduto J, Herscovici D Jr, Sanders RW, DiPasquale T (2002) Iatrogenic nerve injury in acetabular fracture surgery: a comparison of monitored and unmonitored procedures. J Orthop Trauma 16(5):297–301
Beaulé PE, Dorey FJ, Matta JM (2003) Letournel classification for acetabular fractures, vol 85. Assessment of Interobserver and Intraobserver Reliability, vol 9
Acknowledgments
We thank all members of the Pelvic Trauma Working Group of the German Trauma Association, who continuously invest a lot of time and effort in scientific projects and the procurement of knowledge leading to a continuous improvement of the standards of care for patients with pelvic and acetabular fractures in Germany. Without their efforts, the German Pelvic Trauma Registry and this study would not have been possible.
Institutions contributing to the German Pelvic Trauma Registry include the following: ZNA Stuivenberg Antwerpen, Belgium; AZ Groeninge Hospital, Kortrijk, Belgium; Jolimont-Lobbes Hospital, Lobbes, Belgium; University Hospital Aachen, Aachen, Germany; General Hospital Augsburg, Germany; Charité Campus Virchow Hospital, Berlin, Germany; Kreisklinik Biberach, Germany; Municipal Hospital, Braunschweig, Germany; General Hospital, Celle, Germany; General Hospital Dortmund, Germany; Diakonissenkrankenhaus, Flensburg, Germany; University Hospital, Freiburg, Germany; BG Trauma Hospital, Halle, Germany; University Hospital, Halle, Germany; University Hospital, Hamburg, Germany; Friederikenstift Hospital, Hannover, Germany; Medizinische Hochschule, Hannover, Germany; University Hospital, Homburg, Germany; University Hospital, Jena, Germany; Westpfalz Hospital, Kaiserslautern, Germany; Municipal Hospital Karlsruhe, Germany; University Hospital, Kiel, Germany; SKM Hospital, Koblenz, Germany; University Hospital, Leipzig, Germany; General Hospital, Ludwigsburg, Germany; BG Trauma Hospital, Ludwigshafen, Germany; University Hospital, Mainz, Germany; University Hospital, Magdeburg, Germany; Hospital of the Technical University, Munich, Germany; BG Trauma Hospital, Murnau, Germany; University Hospital, Münster, Germany; Municipal Hospital Nuernberg, Germany; University Hospital, Regensburg, Germany; Klinikum Schwerin, Germany; BG Trauma Hospital, Tübingen, Germany; German Army Hospital, Ulm, Germany; University Hospital, Ulm, Germany; and Sahlgrenska University Hospital, Gothenburg, Sweden.
Funding
An unrestricted institutional grant was received by the Deutsche Arthrosehilfe e.V. to complete the scientific study at the Study Center—UKS Trauma—of the Department of Trauma, Hand and Reconstructive Surgery, Saarland University.
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Tim Pohlemann is the head of the TK system of the AO Foundation (nonprofit). Those activities are unrelated to the presented topic. All other authors declare that they have no conflict of interest.
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The German Pelvic Trauma Registry of the German Association of Trauma Surgery (DGU)
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Rollmann, M.F., Holstein, J.H., Pohlemann, T. et al. Predictors for secondary hip osteoarthritis after acetabular fractures—a pelvic registry study. International Orthopaedics (SICOT) 43, 2167–2173 (2019). https://doi.org/10.1007/s00264-018-4169-3
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DOI: https://doi.org/10.1007/s00264-018-4169-3