Skip to main content

Advertisement

Log in

Predictors for secondary hip osteoarthritis after acetabular fractures—a pelvic registry study

  • Original Paper
  • Published:
International Orthopaedics Aims and scope Submit manuscript

Abstract

Purpose

Secondary hip osteoarthritis after acetabular fractures requiring total arthroplasty (THA) poses a huge burden on the affected patients as well as health systems. The present study aimed to assess risk factors associated with THA after acetabular fractures based on the data from the German Pelvic Trauma Registry.

Methods

Retrospective analysis of 678 acetabular fracture cases without concomitant pelvic ring fracture treated and followed-up between January 2004 and May 2015 at six large trauma centres. Multivariate Cox regression analysis was performed assessing the association of patient/treatment characteristics with THA likelihood at an average follow-up of 2.7 years (range 0.4–9.5 years; SD 1.8 years).

Results

Overall, the rate of secondary osteoarthritis was 19.8%. The likelihood for THA increased with 6% per age year (95% CI 1.04–1.09) and with 21% per millimetre subluxation (95%CI 1.09–1.33). This likelihood was 3.54 (95% CI 1.77–7.08) and 3.68 times (95% CI 1.87–7.47) higher if the posterior wall was involved and a contusion and/or impaction of the femoral head was present. Other covariates (sex, ISS, trauma type, AO/OTA and Letournel classification, initial displacement, surgical approach, intra-articular fragments, contusion and/or impaction to the acetabulum, reduction, intervention type, duration of surgery, soft tissue damage, residual fracture step/gap, and prevention of heterotopic ossifications) were not significantly associated (p > 0.15).

Conclusions

Twenty percent of patients with acetabular fractures require THA. The associated risk factors are patient age, femoral head lesion/subluxation, and involvement of the posterior wall. The identified risk factors support previous research and should be minded when treatment of acetabular fractures is planned.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Nho SJ, Kymes SM, Callaghan JJ, Felson DT (2013) The burden of hip osteoarthritis in the United States: epidemiologic and economic considerations. J Am Acad Orthop Surg 21(Suppl 1):S1–S6. https://doi.org/10.5435/JAAOS-21-07-S1

    Article  PubMed  Google Scholar 

  2. Luthje P, Helkamaa T, Nurmi-Luthje I, Kaukonen JP, Kataja M (2014) An 8-year follow-up study of 221 consecutive hip fracture patients in Finland: analysis of reoperations and their direct medical costs. Scand J Surg 103(1):46–53. https://doi.org/10.1177/1457496913494726

    Article  CAS  PubMed  Google Scholar 

  3. O’Toole RV, Hui E, Chandra A, Nascone JW (2014) How often does open reduction and internal fixation of geriatric acetabular fractures lead to hip arthroplasty? J Orthop Trauma 28(3):148–153. https://doi.org/10.1097/BOT.0b013e31829c739a

    Article  PubMed  Google Scholar 

  4. Giannoudis PV, Grotz MR, Papakostidis C, Dinopoulos H (2005) Operative treatment of displaced fractures of the acetabulum. A meta-analysis. J Bone Joint Surg Br 87(1):2–9

    Article  CAS  Google Scholar 

  5. Tannast M, Najibi S, Matta JM (2012) Two to twenty-year survivorship of the hip in 810 patients with operatively treated acetabular fractures. J Bone Joint Surg Am 94(17):1559–1567. https://doi.org/10.2106/JBJS.K.00444

    Article  PubMed  Google Scholar 

  6. Boudissa M, Ruatti S, Kerschbaumer G, Milaire M, Merloz P, Tonetti J (2016) Part 2: outcome of acetabular fractures and associated prognostic factors-a ten-year retrospective study of one hundred and fifty six operated cases with open reduction and internal fixation. Int Orthop 40(10):2151–2156. https://doi.org/10.1007/s00264-015-3070-6

    Article  PubMed  Google Scholar 

  7. Kühn K, D’Lima DD, Hashimoto S, Lotz M (2004) Cell death in cartilage. Osteoarthr Cartil 12(1):1–16. https://doi.org/10.1016/j.joca.2003.09.015

    Article  PubMed  Google Scholar 

  8. Dirschl DR, Marsh JL, Buckwalter JA, Gelberman R, Olson SA, Brown TD, Llinias A (2004) Articular fractures. J Am Acad Orthop Surg 12(6):416–423

    Article  PubMed  Google Scholar 

  9. Wassilew GI, Lehnigk U, Duda GN, Taylor WR, Matziolis G, Dynybil C (2010) The expression of proinflammatory cytokines and matrix metalloproteinases in the synovial membranes of patients with osteoarthritis compared with traumatic knee disorders. Arthroscopy 26(8):1096–1104. https://doi.org/10.1016/j.arthro.2009.12.018

    Article  PubMed  Google Scholar 

  10. Seifer DR, Furman BD, Guilak F, Olson SA, Brooks SC 3rd, Kraus VB (2008) Novel synovial fluid recovery method allows for quantification of a marker of arthritis in mice. Osteoarthritis and cartilage/OARS, Osteoarthritis Research Society 16(12):1532–1538. https://doi.org/10.1016/j.joca.2008.04.013

    Article  CAS  PubMed Central  Google Scholar 

  11. Martin JA, Buckwalter JA (2002) Aging, articular cartilage chondrocyte senescence and osteoarthritis. Biogerontology 3(5):257–264

    Article  CAS  PubMed  Google Scholar 

  12. Beecher BR, Martin JA, Pedersen DR, Heiner AD, Buckwalter JA (2007) Antioxidants block cyclic loading induced chondrocyte death. Iowa Orthop J 27:1–8

    CAS  PubMed  PubMed Central  Google Scholar 

  13. Buckwalter JA, Martin JA (2006) Osteoarthritis. Adv Drug Deliv Rev 58(2):150–167. https://doi.org/10.1016/j.addr.2006.01.006

    Article  CAS  PubMed  Google Scholar 

  14. Valdes AM, Doherty SA, Muir KR, Wheeler M, Maciewicz RA, Zhang W, Doherty M (2013) The genetic contribution to severe post-traumatic osteoarthritis. Ann Rheum Dis 72(10):1687–1690. https://doi.org/10.1136/annrheumdis-2012-202562

    Article  PubMed  PubMed Central  Google Scholar 

  15. Hashimoto S, Rai MF, Janiszak KL, Cheverud JM, Sandell LJ (2012) Cartilage and bone changes during development of post-traumatic osteoarthritis in selected LGXSM recombinant inbred mice. Osteoarthritis and cartilage/OARS, Osteoarthritis Research Society 20(6):562–571. https://doi.org/10.1016/j.joca.2012.01.022

    Article  CAS  Google Scholar 

  16. Lehmann W, Hoffmann M, Fensky F, Nuchtern J, Grossterlinden L, Aghayev E, Lehmann H, Stuby F, Rueger JM (2014) What is the frequency of nerve injuries associated with acetabular fractures? Clin Orthop Relat Res 472(11):3395–3403. https://doi.org/10.1007/s11999-014-3838-9

    Article  PubMed  PubMed Central  Google Scholar 

  17. Hauschild O, Aghayev E, von Heyden J, Strohm PC, Culemann U, Pohlemann T, Suedkamp NP, Schmal H (2012) Angioembolization for pelvic hemorrhage control: results from the German pelvic injury register. J Trauma Acute Care Surg 73 (3):679–684. https://doi.org/10.1097/TA.0b013e318253b5ba

  18. AO/OTA (2007) Pelvis J Orthop Trauma 21 (Suppl10) (10):S59-S67

  19. Letournel E (1980) Acetabulum fractures: classification and management. Clin Orthop Relat Res 151:81–106

    Google Scholar 

  20. Burkhardt M, Nienaber U, Krause J, Pizanis A, Moersdorf P, Culemann U, Aghayev E, Paffrath T, Pohlemann T, Holstein JH, Beckenregister DGU, TraumaRegister DGU (2014) Complex pelvic traumas : data linkage of the German pelvic injury register and the TraumaRegister DGU(R). Unfallchirurg. https://doi.org/10.1007/s00113-014-2565-8

  21. Bosch U, Pohlemann T, Haas N, Tscherne H (1992) Classification and management of complex pelvic trauma. Unfallchirurg 95(4):189–196

    CAS  PubMed  Google Scholar 

  22. Judet R, Judet J, Letournel E (1964) Fractures of the acetabulum. Acta Orthop Belg 30:285–293

    CAS  PubMed  Google Scholar 

  23. Clarke-Jenssen J, Roise O, Storeggen SAO, Madsen JE (2017) Long-term survival and risk factors for failure of the native hip joint after operatively treated displaced acetabular fractures. Bone Joint J 99-B(6):834–840. https://doi.org/10.1302/0301-620X.99B6.BJJ-2016-1013.R1

    Article  CAS  PubMed  Google Scholar 

  24. Boelch SP, Jordan MC, Meffert RH, Jansen H (2017) Comparison of open reduction and internal fixation and primary total hip replacement for osteoporotic acetabular fractures: a retrospective clinical study. Int Orthop 41(9):1831–1837. https://doi.org/10.1007/s00264-016-3260-x

    Article  PubMed  Google Scholar 

  25. Salama W, Mousa S, Khalefa A, Sleem A, Kenawey M, Ravera L, Masse A (2017) Simultaneous open reduction and internal fixation and total hip arthroplasty for the treatment of osteoporotic acetabular fractures. Int Orthop 41(1):181–189. https://doi.org/10.1007/s00264-016-3175-6

    Article  PubMed  Google Scholar 

  26. Bogdan Y, Dwivedi S, Tornetta P, 3rd (2014) A surgical approach algorithm for transverse posterior wall fractures aids in reduction quality. Clin Orthop Relat Res 472 (11):3338–3344. https://doi.org/10.1007/s11999-014-3634-6

  27. Haidukewych GJ, Scaduto J, Herscovici D Jr, Sanders RW, DiPasquale T (2002) Iatrogenic nerve injury in acetabular fracture surgery: a comparison of monitored and unmonitored procedures. J Orthop Trauma 16(5):297–301

    Article  PubMed  Google Scholar 

  28. Beaulé PE, Dorey FJ, Matta JM (2003) Letournel classification for acetabular fractures, vol 85. Assessment of Interobserver and Intraobserver Reliability, vol 9

Download references

Acknowledgments

We thank all members of the Pelvic Trauma Working Group of the German Trauma Association, who continuously invest a lot of time and effort in scientific projects and the procurement of knowledge leading to a continuous improvement of the standards of care for patients with pelvic and acetabular fractures in Germany. Without their efforts, the German Pelvic Trauma Registry and this study would not have been possible.

Institutions contributing to the German Pelvic Trauma Registry include the following: ZNA Stuivenberg Antwerpen, Belgium; AZ Groeninge Hospital, Kortrijk, Belgium; Jolimont-Lobbes Hospital, Lobbes, Belgium; University Hospital Aachen, Aachen, Germany; General Hospital Augsburg, Germany; Charité Campus Virchow Hospital, Berlin, Germany; Kreisklinik Biberach, Germany; Municipal Hospital, Braunschweig, Germany; General Hospital, Celle, Germany; General Hospital Dortmund, Germany; Diakonissenkrankenhaus, Flensburg, Germany; University Hospital, Freiburg, Germany; BG Trauma Hospital, Halle, Germany; University Hospital, Halle, Germany; University Hospital, Hamburg, Germany; Friederikenstift Hospital, Hannover, Germany; Medizinische Hochschule, Hannover, Germany; University Hospital, Homburg, Germany; University Hospital, Jena, Germany; Westpfalz Hospital, Kaiserslautern, Germany; Municipal Hospital Karlsruhe, Germany; University Hospital, Kiel, Germany; SKM Hospital, Koblenz, Germany; University Hospital, Leipzig, Germany; General Hospital, Ludwigsburg, Germany; BG Trauma Hospital, Ludwigshafen, Germany; University Hospital, Mainz, Germany; University Hospital, Magdeburg, Germany; Hospital of the Technical University, Munich, Germany; BG Trauma Hospital, Murnau, Germany; University Hospital, Münster, Germany; Municipal Hospital Nuernberg, Germany; University Hospital, Regensburg, Germany; Klinikum Schwerin, Germany; BG Trauma Hospital, Tübingen, Germany; German Army Hospital, Ulm, Germany; University Hospital, Ulm, Germany; and Sahlgrenska University Hospital, Gothenburg, Sweden.

Funding

An unrestricted institutional grant was received by the Deutsche Arthrosehilfe e.V. to complete the scientific study at the Study Center—UKS Trauma—of the Department of Trauma, Hand and Reconstructive Surgery, Saarland University.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Mika F. Rollmann.

Ethics declarations

Conflict of interest

Tim Pohlemann is the head of the TK system of the AO Foundation (nonprofit). Those activities are unrelated to the presented topic. All other authors declare that they have no conflict of interest.

Additional information

The German Pelvic Trauma Registry of the German Association of Trauma Surgery (DGU)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Rollmann, M.F., Holstein, J.H., Pohlemann, T. et al. Predictors for secondary hip osteoarthritis after acetabular fractures—a pelvic registry study. International Orthopaedics (SICOT) 43, 2167–2173 (2019). https://doi.org/10.1007/s00264-018-4169-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00264-018-4169-3

Keywords

Navigation