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Phenotypic characteristics of commonly used inbred mouse strains

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Abstract

The laboratory mouse is the most commonly used mammalian model for biomedical research. An enormous number of mouse models, such as gene knockout, knockin, and overexpression transgenic mice, have been created over the years. A common practice to maintain a genetically modified mouse line is backcrossing with standard inbred mice over several generations. However, the choice of inbred mouse for backcrossing is critical to phenotypic characterization because phenotypic variabilities are often observed between mice with different genetic backgrounds. In this review, the major features of commonly used inbred mouse lines are discussed. The aim is to provide information for appropriate selection of inbred mouse lines for genetic and behavioral studies.

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This work was financially supported by The Hong Kong Polytechnic University (ZVN0).

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  1. University Research Facility in Behavioral and Systems Neuroscience, The Hong Kong Polytechnic University, Hong Kong, SAR, China

    Wing Yip Tam

  2. Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong, SAR, China

    Kwok-Kuen Cheung

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WYT and KKC wrote this review article.

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Tam, W.Y., Cheung, KK. Phenotypic characteristics of commonly used inbred mouse strains. J Mol Med 98, 1215–1234 (2020). https://doi.org/10.1007/s00109-020-01953-4

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