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The role of immune dysfunction in obesity-associated cancer risk, progression, and metastasis

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Abstract

Obesity has been linked to an increased risk of and a worse prognosis for several types of cancer. A number of interrelated mediators contribute to obesity’s pro-tumor effects, including chronic adipose inflammation and other perturbations of immune cell development and function. Here, we review studies examining the impact of obesity-induced immune dysfunction on cancer risk and progression. While the role of adipose tissue inflammation in obesity-associated cancer risk has been well characterized, the effects of obesity on immune cell infiltration and activity within the tumor microenvironment are not well studied. In this review, we aim to highlight the impact of both adipose-mediated inflammatory signaling and intratumoral immunosuppressive signaling in obesity-induced cancer risk, progression, and metastasis.

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  1. Department of Nutrition Science, College of Health and Human Sciences, Purdue University, West Lafayette, IN, 47906, USA

    Aneesha Kulkarni & Laura W. Bowers

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  1. Aneesha Kulkarni
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AK performed the literature review and wrote the manuscript; LB supervised the review and writing process and edited the manuscript.

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Kulkarni, A., Bowers, L.W. The role of immune dysfunction in obesity-associated cancer risk, progression, and metastasis. Cell. Mol. Life Sci. 78, 3423–3442 (2021). https://doi.org/10.1007/s00018-020-03752-z

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