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Sirtuin Modulator: Design, Synthesis, and Biological Evaluation

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Natural Product-based Synthetic Drug Molecules in Alzheimer's Disease

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Abstract

A family of signalling proteins called sirtuins is involved in the control of metabolism. The sirtuin family of NAD+-dependent protein lysine deacylases controls a range of physiological processes, including stress reactions and energy metabolism. For ageing-related illnesses such type 2 diabetes, inflammatory diseases, gene repression, metabolic regulation, apoptosis and cell survival, DNA repair, and neurodegenerative disorders, the human sirtuin isoforms (1–7) are thought to be promising therapeutic targets. The search for small compounds that alter the activity of sirtuins is becoming more and more popular since it may have positive implications on treating human ailments. Here, we discussed the sirtuin synthesis, biological importance, potent and specific pharmacological sirtuin activators and inhibitors, isoforms, and the current status of sirtuin-targeted therapeutic research. The rationale behind continued medication development is based on the progressive understanding of the sirtuin modulation processes by such compounds.

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Authors and Affiliations

  1. Integrated Drug Discovery Research Laboratory, Department of Pharmaceutical Sciences, Dr. Hasrisingh Gour University (A Central University), Sagar, Madhya Pradesh, India

    Shivam Kumar Kori, Satyamshyam Vishwakarma, Vandana Soni & Sushil Kumar Kashaw

  2. Department of Chemistry, Dr. Harisingh Gour University (A Central University), Sagar, Madhya Pradesh, India

    Sandhya Pathak

  3. Sagar Institute of Pharmaceutical Sciences, Sagar, Madhya Pradesh, India

    Varsha Kashaw

  4. Use-Inspired Biomaterials & Integrated Nano Delivery (U-BiND) Systems Laboratory, Department of Pharmaceutical Sciences, Wayne State University, Detroit, MI, USA

    Arun K. Iyer

  5. Molecular Imaging Program, Karmanos Cancer Institute, Detroit, MI, USA

    Arun K. Iyer

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  1. Shivam Kumar Kori
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  2. Satyamshyam Vishwakarma
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  3. Sandhya Pathak
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  4. Varsha Kashaw
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  5. Vandana Soni
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  6. Arun K. Iyer
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  7. Sushil Kumar Kashaw
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Editors and Affiliations

  1. Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Raebareli, Uttar Pradesh, India

    Abha Sharma

  2. Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology BHU, Varanasi, Uttar Pradesh, India

    Gyan Prakash Modi

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Kori, S.K. et al. (2023). Sirtuin Modulator: Design, Synthesis, and Biological Evaluation. In: Sharma, A., Modi, G.P. (eds) Natural Product-based Synthetic Drug Molecules in Alzheimer's Disease. Springer, Singapore. https://doi.org/10.1007/978-981-99-6038-5_15

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  • DOI: https://doi.org/10.1007/978-981-99-6038-5_15

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