Overview
Examines natural products as source of novel drug against Alzheimer’s disease
Covers the role of metal homeostasis and oxidative stress in the pathogenesis of Alzheimer’s disease
Discusses the role of neuroinflammation in progression of Alzheimer’s disease
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Table of contents (16 chapters)
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Front Matter
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Introduction of Alzheimer’s Disease
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Front Matter
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Biomarkers and Diagnosis in Alzheimer’s Disease
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Drug Derivatives: A Strategy for New Multifunctional Drug Development for Alzheimer’s Disease
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Natural Molecules Inspired Novel Derivatives for Alzheimer’s Disease
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Metal Dyshomeostasis: A Hypothesis for Developing Drugs for the Treatment of Alzheimer’s Disease
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Keywords
About this book
Editors and Affiliations
About the editors
Dr. Abha Sharma is working as an associate professor in the department of medicinal chemistry at National Institute of Pharmaceutical Education and Research, Raebareli, India. She earned her Ph.D. from the Defence Research and Development Establishment (awarded by Jiwaji University), Gwalior, India, 2006. She has worked at Indian Institute of Toxicology Research (IITR), Lucknow as a research associate for more than three and a half years. Her research area includes design and synthesis of molecules for the treatment of Alzheimer’s disease and the development of sensors/probes for the detection of analytes/biomarkers of central nervous system diseases like AD. She published more than 40 papers in high-impact journals, several book chapters, and filed patents. She has served as a referee for a number of international journals and several students have completed their research projects under her guidance.
Dr. Gyan Prakash Modi is working as an assistant professor in the department of pharmaceutical engineering and technology, Indian Institute of Technology (BHU), Varanasi, India. He earned a Ph.D. from the department of pharmaceutical sciences, Wayne State University, Detroit, Michigan, USA, in 2013, followed by postdoctoral training at Brandeis University, Waltham, Massachusetts, USA. His research area includes drug development for neurodegenerative diseases, inhibitor design, and the development of novel (near-infrared) NIR probes targeting various chronic central nervous system diseases like Alzheimer's disease (AD). He published nearly 25 research papers in high-impact journals and filed several patents, including four US patents in medicinal chemistry. He has been selected as a young investigator to attend YIM 2019 organized by India Bioscience at IIT Guwahati, he is also the recipient of several awards including outstanding scientist in medicinal chemistry, Venus international foundation.
Bibliographic Information
Book Title: Natural Product-based Synthetic Drug Molecules in Alzheimer's Disease
Book Subtitle: Therapeutic & Theranostic Agents
Editors: Abha Sharma, Gyan Prakash Modi
DOI: https://doi.org/10.1007/978-981-99-6038-5
Publisher: Springer Singapore
eBook Packages: Medicine, Medicine (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2023
Hardcover ISBN: 978-981-99-6037-8Published: 16 December 2023
Softcover ISBN: 978-981-99-6040-8Due: 30 December 2024
eBook ISBN: 978-981-99-6038-5Published: 15 December 2023
Edition Number: 1
Number of Pages: XIII, 447
Number of Illustrations: 1 b/w illustrations
Topics: Neurosciences, Pharmacology/Toxicology, Neurology