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Predicting the Outcome of Arsenic Toxicity on Exposed Juvenile Male-Humans: A Shift to Infertility

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Arsenic Toxicity: Challenges and Solutions

Abstract

Toxicity caused by arsenic ingestion on the health of the human male reproductive axis has been researched upon. Numerous pathways linking arsenic toxicity including the endocrine system and hormonal cascade have been elucidated. In this text, several aspects of arsenic effect on human reproductive health, including how arsenic triggered DNA methylation, deregulate spermatogenesis, and decline sperm quality will be discussed. The route of arsenic ingestion, connecting occupational exposure, and polluted water resources are verily implicated in the etiology of arsenic effect on male infertility. Nevertheless, the populaces are worried about how their reproductive health is negatively impacted by arsenic ingestion and its derivatives or combinations. This text exposes several areas, pathways, and mechanisms of actions that necessarily lead to male infertility overtime if adequate intervention and awareness are not brought to bear. The endpoint is that knowledge and awareness by individuals is a key to provoking environmental health campaigns and strategic intervention plans to ameliorate arsenic effect. Diagnostics instruments may be required to avert the onset of arsenic effect before the manifestation and complication of infertility in men due to arsenic ingestion. Therefore, if the knowledge and clinical evidence present here is not appreciated, it will be predicted that over time, there will be physical appearance of two different sexes, with sexually inactive men. That will be the predictive shift to infertility by men due to the effect caused by arsenic and its combination.

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Authors and Affiliations

  1. Department of Biochemistry, Cross River University of Technology, Calabar, Nigeria

    Victor Eshu Okpashi

  2. Department of Chemistry, Cross River University of Technology, Calabar, Nigeria

    Abeng Fidelis Ebunta

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  1. Victor Eshu Okpashi
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  1. Department of Biotechnology, Central University of South Bihar, Gaya, Bihar, India

    Nitish Kumar

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Okpashi, V.E., Ebunta, A.F. (2021). Predicting the Outcome of Arsenic Toxicity on Exposed Juvenile Male-Humans: A Shift to Infertility. In: Kumar, N. (eds) Arsenic Toxicity: Challenges and Solutions. Springer, Singapore. https://doi.org/10.1007/978-981-33-6068-6_1

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