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Microbicidal Nanoparticles

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Synthesis and Applications of Nanoparticles

Abstract

Nanomaterials exhibit tremendous exciting properties and transform every aspect of science and technology. Microbiology has also not remained untouched from nanotechnology applications and utilization. Antimicrobial materials are one of the major concerns of microbiology research due to increasing challenges of microbial resistance for antibiotics and continuous mutation in microorganisms. Nanoparticles are found to exhibit excellent antimicrobial properties. Nanoparticles of gold, silver, selenium, tin oxide, zinc oxide, nickel, platinum, etc. were found to have excellent antimicrobial properties. These nanoparticles can be utilized for a wide range of antimicrobial applications. Antimicrobial coating, targeted delivery of antibiotics, nanoparticle conjugate with antibiotics, and antimicrobials are a few of the applications of nanoparticles as antimicrobials. Researchers utilized nanoparticles for coating on medical devices to keep them infection-free. The traditional antibiotics are found ineffective on several multidrug-resistant bacteria, and nanoparticles in conjugation or alone may provide the solution for such challenges. The nanoparticles are found to have great antioxidant activity, and nanoparticles in the size range of 5–100 nm can directly forage free radicals in vitro. Researchers also reported excellent antimicrobial properties of nanoparticles when capped or conjugated with antibiotics/antibodies. The agar well diffusion method and minimum inhibition concentration (MIC) method are widely used by most of the researchers for determination of antimicrobial properties of nanoparticles.

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Acknowledgments

The authors are grateful to the Vice Chancellor, King George’s Medical University (KGMU), Lucknow, India, for the encouragement of this work. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

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Authors and Affiliations

  1. Department of Biotechnology, Meerut Institute of Engineering and Technology, Meerut, India

    Nishant Srivastava

  2. Centre for Advanced Research (CFAR), Faculty of Medicine, King George’s Medical University (KGMU), Lucknow, India

    Shailendra K. Saxena

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  1. Nishant Srivastava
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  2. Shailendra K. Saxena
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Correspondence to Shailendra K. Saxena .

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Editors and Affiliations

  1. Centre of Nanotechnology, Amity University Haryana, Gurugram, Haryana, India

    Atul Thakur

  2. Department of Physics, Amity School of Applied Sciences, Amity University Haryana, Gurugram, Haryana, India

    Preeti Thakur

  3. Science Instrumentation Centre, Amity University Haryana, Gurugram, Haryana, India

    S.M. Paul Khurana

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Srivastava, N., Saxena, S.K. (2022). Microbicidal Nanoparticles. In: Thakur, A., Thakur, P., Khurana, S.P. (eds) Synthesis and Applications of Nanoparticles. Springer, Singapore. https://doi.org/10.1007/978-981-16-6819-7_17

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