Abstract
Microorganisms develop resistance to antimicrobial compounds, which is an important global health threat. As per the World Health Organization (WHO) report, antimicrobial resistance (AMR) is one of the leading causes of mortality worldwide. To overcome antibiotic resistance, nanoscale antimicrobial agents can be used as an alternative strategy. Different types of nanoparticles (NP) such as solid lipid (SL) NPs, liposomal NPs, polymer-based NPs, inorganic NPs, magnetic NPs, mesoporous silica NPs, and carbon nanomaterials are used for drug delivery. Metal nanoparticles (NPs) such as copper (Cu), titanium (Ti), silver (Ag), gold (Au), and zinc (Zn) have antimicrobial activity. The antimicrobial properties of NPs depend on size, chemical composition, and shape of these NPs. The present chapter reviews the application of various nanoparticles as antimicrobial agents and their potential application against multidrug-resistant microbial pathogens in public health. Advancement in nanomedicine is an important aspect for diagnosis and treatment of diseases induced by drug-resistant microorganisms.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Actis L, Srinivasan A, Lopez-Ribot JL et al (2015) Effect of silver nanoparticle geometry on methicillin susceptible and resistant Staphylococcus aureus, and osteoblast viability. J Mater Sci Mater Med 26:215. https://doi.org/10.1007/s10856-015-5538-8
Ahamed M, Alhadlaq HA, Khan MAM et al (2014) Synthesis, characterization, and antimicrobial activity of copper oxide nanoparticles. J Nanomater 2014:1–4. https://doi.org/10.1155/2014/637858
Ahangari A, Salouti M, Heidari Z et al (2013) Development of gentamicin-gold nanospheres for antimicrobial drug delivery to Staphylococcal infected foci. Drug Deliv 20:34–39. https://doi.org/10.3109/10717544.2012.746402
Alizadeh Sani M, Ehsani A, Hashemi M (2017) Whey protein isolate/cellulose nanofibre/TiO 2 nanoparticle/rosemary essential oil nanocomposite film: its effect on microbial and sensory quality of lamb meat and growth of common foodborne pathogenic bacteria during refrigeration. Int J Food Microbiol 251:8–14. https://doi.org/10.1016/j.ijfoodmicro.2017.03.018
Ansari MA, Khan HM, Khan AA et al (2012) Synthesis and characterization of the antibacterial potential of ZnO nanoparticles against extended-spectrum β-lactamases-producing Escherichia coli and Klebsiella pneumoniae isolated from a tertiary care hospital of North India. Appl Microbiol Biotechnol 94:467–477. https://doi.org/10.1007/s00253-011-3733-1
Ansari MA, Khan HM, Khan AA et al (2013) Antibacterial potential of Al2O3 nanoparticles against multidrug resistance strains of Staphylococcus aureus isolated from skin exudates. J Nanopart Res 15:1970. https://doi.org/10.1007/s11051-013-1970-1
Ansari MA, Khan HM, Khan AA et al (2014) Interaction of silver nanoparticles with Escherichia coli and their cell envelope biomolecules. J Basic Microbiol 54:905–915. https://doi.org/10.1002/jobm.201300457
Arakha M, Pal S, Samantarrai D et al (2015) Antimicrobial activity of iron oxide nanoparticle upon modulation of nanoparticle-bacteria interface. Sci Rep 5:14813. https://doi.org/10.1038/srep14813
Awad HM, EL-Shahed KYI, Aziz R et al (2013) Antibiotics as microbial secondary metabolites: production and application. J Teknol 59:101–111. https://doi.org/10.11113/jt.v59.1593
Azam A (2012) Size-dependent antimicrobial properties of CuO nanoparticles against Gram-positive and -negative bacterial strains. Int J Nanomedicine 7:3527–3535. https://doi.org/10.2147/IJN.S29020
Azevedo MM, Ramalho P, Silva AP et al (2014) Polyethyleneimine and polyethyleneimine-based nanoparticles: novel bacterial and yeast biofilm inhibitors. J Med Microbiol 63:1167–1173. https://doi.org/10.1099/jmm.0.069609-0
Baram-Pinto D, Shukla S, Perkas N et al (2009) Inhibition of Herpes Simplex virus type 1 infection by silver nanoparticles capped with mercaptoethane sulfonate. Bioconjug Chem 20:1497–1502. https://doi.org/10.1021/bc900215b
Barnett CM, Gueorguieva M, Lees MR et al (2013) Physical stability, biocompatibility and potential use of hybrid iron oxide-gold nanoparticles as drug carriers. J Nanopart Res 15:1706. https://doi.org/10.1007/s11051-013-1706-2
Bayroodi E, Jalal R (2016) Modulation of antibiotic resistance in Pseudomonas aeruginosa by ZnO nanoparticles. Iran J Microbiol 8:85–92
Behera SS, Patra JK, Pramanik K et al (2012) Characterization and evaluation of antibacterial activities of chemically synthesized iron oxide nanoparticles. World J Nano Sci Eng 02:196–200. https://doi.org/10.4236/wjnse.2012.24026
Bera RK, Mandal SM, Raj CR (2014) Antimicrobial activity of fluorescent Ag nanoparticles. Lett Appl Microbiol 58:520–526. https://doi.org/10.1111/lam.12222
Bhainsa KC, D’Souza SF (2006) Extracellular biosynthesis of silver nanoparticles using the fungus Aspergillus fumigatus. Colloids Surf B Biointerfaces 47:160–164. https://doi.org/10.1016/j.colsurfb.2005.11.026
Birla SS, Tiwari VV, Gade AK et al (2009) Fabrication of silver nanoparticles by Phoma glomerata and its combined effect against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. Lett Appl Microbiol 48:173–179. https://doi.org/10.1111/j.1472-765X.2008.02510.x
Carrillo-Muñoz AJ, Quindós G, Tur C et al (1999) In-vitro antifungal activity of liposomal nystatin in comparison with nystatin, amphotericin B cholesteryl sulphate, liposomal amphotericin B, amphotericin B lipid complex, amphotericin B desoxycholate, fluconazole and itraconazole. J Antimicrob Chemother 44:397–401. https://doi.org/10.1093/jac/44.3.397
Cha S-H, Hong J, McGuffie M et al (2015) Shape-dependent biomimetic inhibition of enzyme by nanoparticles and their antibacterial activity. ACS Nano 9:9097–9105. https://doi.org/10.1021/acsnano.5b03247
Chang C-H, Lin Y-H, Yeh C-L et al (2010) Nanoparticles incorporated in pH-sensitive hydrogels as amoxicillin delivery for eradication of Helicobacter pylori. Biomacromolecules 11:133–142. https://doi.org/10.1021/bm900985h
Chatterjee AK, Sarkar RK, Chattopadhyay AP et al (2012) A simple robust method for synthesis of metallic copper nanoparticles of high antibacterial potency against E. coli. Nanotechnology 23:085103. https://doi.org/10.1088/0957-4484/23/8/085103
Chen W-J, Tsai P-J, Chen Y-C (2008) Functional Fe3O4/TiO2 core/shell magnetic nanoparticles as photokilling agents for pathogenic bacteria. Small 4:485–491. https://doi.org/10.1002/smll.200701164
Chorianopoulos NG, Tsoukleris DS, Panagou EZ et al (2011) Use of titanium dioxide (TiO2) photocatalysts as alternative means for Listeria monocytogenes biofilm disinfection in food processing. Food Microbiol 28:164–170. https://doi.org/10.1016/j.fm.2010.07.025
Cousins BG, Allison HE, Doherty PJ et al (2007) Effects of a nanoparticulate silica substrate on cell attachment of Candida albicans. J Appl Microbiol 102:757–765. https://doi.org/10.1111/j.1365-2672.2006.03124.x
Cui Y, Zhao Y, Tian Y et al (2012) The molecular mechanism of action of bactericidal gold nanoparticles on Escherichia coli. Biomaterials 33:2327–2333. https://doi.org/10.1016/j.biomaterials.2011.11.057
des Rieux A, Fievez V, Garinot M et al (2006) Nanoparticles as potential oral delivery systems of proteins and vaccines: a mechanistic approach. J Control Release 116:1–27. https://doi.org/10.1016/j.jconrel.2006.08.013
Di Gianvincenzo P, Marradi M, Martínez-Ávila OM et al (2010) Gold nanoparticles capped with sulfate-ended ligands as anti-HIV agents. Bioorg Med Chem Lett 20:2718–2721. https://doi.org/10.1016/j.bmcl.2010.03.079
Ding D, Zhu Q (2018) Recent advances of PLGA micro/nanoparticles for the delivery of biomacromolecular therapeutics. Mater Sci Eng C 92:1041–1060. https://doi.org/10.1016/j.msec.2017.12.036
Drlica K, Malik M, Kerns RJ, Zhao X (2008) Quinolone-mediated bacterial death. Antimicrob Agents Chemother 52:385–392. https://doi.org/10.1128/AAC.01617-06
Elsabahy M, Wooley KL (2012) Design of polymeric nanoparticles for biomedical delivery applications. Chem Soc Rev 41(7):2545–2561
El-Nahrawy AM, Ali AI, Abou Hammad AB, Youssef AM (2016) Influences of Ag-NPs doping chitosan/calcium silicate nanocomposites for optical and antibacterial activity. Int J Biol Macromol 93:267–275. https://doi.org/10.1016/j.ijbiomac.2016.08.045
El-Shanshoury AE-RR, ElSilk SE, Ebeid ME (2011) Extracellular biosynthesis of silver nanoparticles using Escherichia coli ATCC 8739, Bacillus subtilis ATCC 6633, and Streptococcus thermophilus ESh1 and their antimicrobial activities. ISRN Nanotechnol 2011:1–7. https://doi.org/10.5402/2011/385480
Emami-Karvani Z (2012) Antibacterial activity of ZnO nanoparticle on Gram-positive and Gram-negative bacteria. African J Microbiol Res 5:1368–1373. https://doi.org/10.5897/AJMR10.159
Espinosa-Cristobal LF, Martinez-Castañon GA, Loyola-Rodriguez JP et al (2013) Toxicity, distribution, and accumulation of silver nanoparticles in Wistar rats. J Nanopart Res 15:1702. https://doi.org/10.1007/s11051-013-1702-6
Espitia PJP, Soares N de FF, Coimbra JS dos R et al (2012) Zinc oxide nanoparticles: synthesis, antimicrobial activity and food packaging applications. Food Bioprocess Technol 5:1447–1464. https://doi.org/10.1007/s11947-012-0797-6
Espitia PJP, Soares NDFF, Teófilo RF et al (2013) Optimized dispersion of ZnO nanoparticles and antimicrobial activity against foodborne pathogens and spoilage microorganisms. J Nanopart Res 15:1324. https://doi.org/10.1007/s11051-012-1324-4
Franci G, Falanga A, Galdiero S, Palomba L, Rai M, Morelli G, Galdiero M (2015) Silver nanoparticles as potential antibacterial agents. Molecules 20:8856–8874
Geilich BM, Gelfat I, Sridhar S et al (2017) Superparamagnetic iron oxide-encapsulating polymersome nanocarriers for biofilm eradication. Biomaterials 119:78–85. https://doi.org/10.1016/j.biomaterials.2016.12.011
Ghaedi M, Yousefinejad M, Safarpoor M et al (2015) Rosmarinus officinalis leaf extract mediated green synthesis of silver nanoparticles and investigation of its antimicrobial properties. J Ind Eng Chem 31:167–172. https://doi.org/10.1016/j.jiec.2015.06.020
Gumiero M, Peressini D, Pizzariello A et al (2013) Effect of TiO2 photocatalytic activity in a HDPE-based food packaging on the structural and microbiological stability of a short-ripened cheese. Food Chem 138:1633–1640. https://doi.org/10.1016/j.foodchem.2012.10.139
Guo BL, Han P, Guo LC et al (2015) The antibacterial activity of Ta-doped ZnO nanoparticles. Nanoscale Res Lett 10(1):336
Gurunathan S, Han JW, Kwon D-N, Kim J-H (2014) Enhanced antibacterial and anti-biofilm activities of silver nanoparticles against Gram-negative and Gram-positive bacteria. Nanoscale Res Lett 9:373. https://doi.org/10.1186/1556-276X-9-373
Haghighi F, Mohammadi SR, Mohammadi P et al (2013) Antifungal activity of TiO2 nanoparticles and EDTA on Candida albicans biofilms. Orig Artic Infect Epidemiol Med 1:33–38
Hajipour MJ, Fromm KM, Akbar Ashkarran A et al (2012) Antibacterial properties of nanoparticles. Trends Biotechnol 30:499–511. https://doi.org/10.1016/j.tibtech.2012.06.004
Hashimoto M, Toshima H, Yonezawa T et al (2014) Responses of RAW264.7 macrophages to water-dispersible gold and silver nanoparticles stabilized by metal-carbon σ -bonds. J Biomed Mater Res Part A 102:1838–1849. https://doi.org/10.1002/jbm.a.34854
He L, Liu Y, Mustapha A, Lin M (2011) Antifungal activity of zinc oxide nanoparticles against Botrytis cinerea and Penicillium expansum. Microbiol Res 166:207–215. https://doi.org/10.1016/j.micres.2010.03.003
Hemeg H (2017) Nanomaterials for alternative antibacterial therapy. Int J Nanomedicine 12:8211–8225. https://doi.org/10.2147/IJN.S132163
Hernandez-Delgadillo R, Velasco-Arias D, Diaz D et al (2012) Zerovalent bismuth nanoparticles inhibit Streptococcus mutans growth and formation of biofilm. Int J Nanomedicine 7:2109–2113. https://doi.org/10.2147/IJN.S29854
Huang L, Li D-Q, Lin Y-J et al (2005) Controllable preparation of Nano-MgO and investigation of its bactericidal properties. J Inorg Biochem 99:986–993. https://doi.org/10.1016/j.jinorgbio.2004.12.022
Janiszewska J, Sowińska M, Rajnisz A et al (2012) Novel dendrimeric lipopeptides with antifungal activity. Bioorg Med Chem Lett 22:1388–1393. https://doi.org/10.1016/j.bmcl.2011.12.051
Jayaseelan C, Ramkumar R, Rahuman AA, Perumal P (2013) Green synthesis of gold nanoparticles using seed aqueous extract of Abelmoschus esculentus and its antifungal activity. Ind Crop Prod 45:423–429. https://doi.org/10.1016/j.indcrop.2012.12.019
Jin T, He Y (2011) Antibacterial activities of magnesium oxide (MgO) nanoparticles against foodborne pathogens. J Nanopart Res 13:6877–6885. https://doi.org/10.1007/s11051-011-0595-5
Jin T, Sun D, Su JY et al (2009) Antimicrobial efficacy of zinc oxide quantum dots against Listeria monocytogenes, Salmonella Enteritidis, and Escherichia coli O157:H7. J Food Sci 74:M46–M52. https://doi.org/10.1111/j.1750-3841.2008.01013.x
Keat CL, Aziz A, Eid AM, Elmarzugi NA (2015) Biosynthesis of nanoparticles and silver nanoparticles. Bioresour Bioprocess 2:47. https://doi.org/10.1186/s40643-015-0076-2
Khezerlou A, Alizadeh-Sani M, Azizi-Lalabadi M, Ehsani A (2018) Nanoparticles and their antimicrobial properties against pathogens including bacteria, fungi, parasites and viruses. Microb Pathog 123:505–526. https://doi.org/10.1016/j.micpath.2018.08.008
Kim YH, Lee DK, Cha HG et al (2006) Preparation and characterization of the antibacterial Cu nanoparticle formed on the surface of SiO 2 nanoparticles. J Phys Chem B 110:24923–24928. https://doi.org/10.1021/jp0656779
Kim YH, Lee DK, Cha HG et al (2007) Synthesis and characterization of antibacterial Ag−SiO 2 nanocomposite. J Phys Chem C 111:3629–3635. https://doi.org/10.1021/jp068302w
Krishnamoorthy K, Manivannan G, Kim SJ et al (2012) Antibacterial activity of MgO nanoparticles based on lipid peroxidation by oxygen vacancy. J Nanopart Res 14:1063. https://doi.org/10.1007/s11051-012-1063-6
Kumari A, Yadav SK, Yadav SC (2010) Biodegradable polymeric nanoparticles based drug delivery systems. Colloids Surf B Biointerfaces 75:1–18. https://doi.org/10.1016/j.colsurfb.2009.09.001
Kuo Y-L, Wang S-G, Wu C-Y et al (2016) Functional gold nanoparticle-based antibacterial agents for nosocomial and antibiotic-resistant bacteria. Nanomedicine 11:2497–2510. https://doi.org/10.2217/nnm-2016-0232
Lara HH, Ayala-Nuñez NV, Ixtepan-Turrent L, Rodriguez-Padilla C (2010) Mode of antiviral action of silver nanoparticles against HIV-1. J Nanobiotechnol 8:1. https://doi.org/10.1186/1477-3155-8-1
Laxminarayan R, Duse A, Wattal C et al (2013) Antibiotic resistance—the need for global solutions. Lancet Infect Dis 13:1057–1098. https://doi.org/10.1016/S1473-3099(13)70318-9
Leid JG, Ditto AJ, Knapp A et al (2012) In vitro antimicrobial studies of silver carbene complexes: activity of free and nanoparticle carbene formulations against clinical isolates of pathogenic bacteria. J Antimicrob Chemother 67:138–148. https://doi.org/10.1093/jac/dkr408
Leroux J-C, Allémann E, De Jaeghere F et al (1996) Biodegradable nanoparticles—from sustained release formulations to improved site specific drug delivery. J Control Release 39:339–350. https://doi.org/10.1016/0168-3659(95)00164-6
Leuba K, Durmus T, Webster TJ (2013) Short communication: carboxylate functionalized superparamagnetic iron oxide nanoparticles (SPION) for the reduction of S. aureus growth post biofilm formation. Int J Nanomedicine 8:731. https://doi.org/10.2147/IJN.S38256
Li B, Logan BE (2004) Bacterial adhesion to glass and metal-oxide surfaces. Colloids Surf B Biointerfaces 36:81–90. https://doi.org/10.1016/j.colsurfb.2004.05.006
Li X, Wang L, Fan Y et al (2012a) Biocompatibility and toxicity of nanoparticles and nanotubes. J Nanomater 2012:1–19. https://doi.org/10.1155/2012/548389
Li Y, Zhang W, Niu J, Chen Y (2012b) Mechanism of photogenerated reactive oxygen species and correlation with the antibacterial properties of engineered metal-oxide nanoparticles. ACS Nano 6:5164–5173. https://doi.org/10.1021/nn300934k
Li X, Robinson SM, Gupta A et al (2014) Functional gold nanoparticles as potent antimicrobial agents against multi-drug-resistant bacteria. ACS Nano 8:10682–10686. https://doi.org/10.1021/nn5042625
Liu Y, He L, Mustapha A et al (2009) Antibacterial activities of zinc oxide nanoparticles against Escherichia coli O157:H7. J Appl Microbiol 107:1193–1201. https://doi.org/10.1111/j.1365-2672.2009.04303.x
Liu M, He D, Yang T et al (2018) An efficient antimicrobial depot for infectious site-targeted chemo-photothermal therapy. J Nanobiotechnol 16:23. https://doi.org/10.1186/s12951-018-0348-z
Lu Z, Zhang J, Yu Z et al (2017) Hydrogel degradation triggered by pH for the smart release of antibiotics to combat bacterial infection. New J Chem 41:432–436. https://doi.org/10.1039/C6NJ03260E
Mahmoudi M, Sant S, Wang B et al (2011) Superparamagnetic iron oxide nanoparticles (SPIONs): development, surface modification and applications in chemotherapy. Adv Drug Deliv Rev 63:24–46. https://doi.org/10.1016/j.addr.2010.05.006
Malarkodi C, Rajeshkumar S, Paulkumar K et al (2014) Biosynthesis and antimicrobial activity of semiconductor nanoparticles against oral pathogens. Bioinorg Chem Appl 2014:1–10. https://doi.org/10.1155/2014/347167
Maleki Dizaj S, Mennati A, Jafari S et al (2015) Antimicrobial activity of carbon-based nanoparticles. Adv Pharm Bull 5:19–23. https://doi.org/10.5681/apb.2015.003
Mallmann EJJ, Cunha FA, Castro BNMF et al (2015) Antifungal activity of silver nanoparticles obtained by green synthesis. Rev Inst Med Trop Sao Paulo 57:165–167. https://doi.org/10.1590/S0036-46652015000200011
Mohammadi G, Nokhodchi A, Barzegar-Jalali M et al (2011) Physicochemical and anti-bacterial performance characterization of clarithromycin nanoparticles as colloidal drug delivery system. Colloids Surf B Biointerfaces 88:39–44. https://doi.org/10.1016/j.colsurfb.2011.05.050
Morones JR, Elechiguerra JL, Camacho A et al (2005) The bactericidal effect of silver nanoparticles. Nanotechnology 16:2346–2353. https://doi.org/10.1088/0957-4484/16/10/059
Mukherjee M, De S (2016) Inactivation of Pseudomonas aeruginosa by chitosan coated iron oxide nanoparticles. Recent Pat Biotechnol 10:133–139. https://doi.org/10.2174/1872208310666160805113554
Mukherjee A, Mohammed Sadiq I, Prathna TC, Chandrasekaran N (2011) Antimicrobial activity of aluminium oxide nanoparticles for potential clinical applications. Sci against Microb Pathog Commun Curr Res Technol Adv 1:245–251
Munger MA, Radwanski P, Hadlock GC et al (2014) In vivo human time-exposure study of orally dosed commercial silver nanoparticles. Nanomedicine 10:1–9. https://doi.org/10.1016/j.nano.2013.06.010
Muzammil S, Hayat S, Fakhar-E-Alam M et al (2018) Nanoantibiotics: future nanotechnologies to combat antibiotic resistance. Front Biosci (Elite Ed) 10:352–374
Naahidi S, Jafari M, Edalat F et al (2013) Biocompatibility of engineered nanoparticles for drug delivery. J Control Release 166:182–194. https://doi.org/10.1016/j.jconrel.2012.12.013
Naika HR, Lingaraju K, Manjunath K et al (2015) Green synthesis of CuO nanoparticles using Gloriosa superba L. extract and their antibacterial activity. J Taibah Univ Sci 9:7–12. https://doi.org/10.1016/j.jtusci.2014.04.006
Nair S, Sasidharan A, Divya Rani VV et al (2009) Role of size scale of ZnO nanoparticles and microparticles on toxicity toward bacteria and osteoblast cancer cells. J Mater Sci Mater Med 20:235–241. https://doi.org/10.1007/s10856-008-3548-5
Naqvi SZ, Kiran U, Ali MI et al (2013) Combined efficacy of biologically synthesized silver nanoparticles and different antibiotics against multidrug-resistant bacteria. Int J Nanomedicine 8:3187–3195. https://doi.org/10.2147/IJN.S49284
Natarajan S, Bhuvaneshwari M, Lakshmi DS et al (2016) Antibacterial and antifouling activities of chitosan/TiO2/Ag NPs nanocomposite films against packaged drinking water bacterial isolates. Environ Sci Pollut Res 23:19529–19540. https://doi.org/10.1007/s11356-016-7102-6
Nayak D, Ashe S, Rauta PR et al (2016) Bark extract mediated green synthesis of silver nanoparticles: evaluation of antimicrobial activity and antiproliferative response against osteosarcoma. Mater Sci Eng C 58:44–52. https://doi.org/10.1016/j.msec.2015.08.022
Nazari P, Dowlatabadi-Bazaz R, Mofid MR et al (2014) The antimicrobial effects and metabolomic footprinting of carboxyl-capped bismuth nanoparticles against Helicobacter pylori. Appl Biochem Biotechnol 172:570–579. https://doi.org/10.1007/s12010-013-0571-x
Ogar A, Tylko G, Turnau K (2015) Antifungal properties of silver nanoparticles against indoor mould growth. Sci Total Environ 521–522:305–314. https://doi.org/10.1016/j.scitotenv.2015.03.101
Padmavathy N, Vijayaraghavan R (2011) Interaction of ZnO nanoparticles with microbes—a physio and biochemical assay. J Biomed Nanotechnol 7:813–822. https://doi.org/10.1166/jbn.2011.1343
Panáček A, Kolář M, Večeřová R et al (2009) Antifungal activity of silver nanoparticles against Candida spp. Biomaterials 30:6333–6340. https://doi.org/10.1016/j.biomaterials.2009.07.065
Pereira L, Dias N, Carvalho J et al (2014) Synthesis, characterization and antifungal activity of chemically and fungal-produced silver nanoparticles against Trichophyton rubrum. J Appl Microbiol 117:1601–1613. https://doi.org/10.1111/jam.12652
Pérez-Díaz MA, Boegli L, James G et al (2015) Silver nanoparticles with antimicrobial activities against Streptococcus mutans and their cytotoxic effect. Mater Sci Eng C 55:360–366. https://doi.org/10.1016/j.msec.2015.05.036
Prabhu S, Poulose EK (2012) Silver nanoparticles: mechanism of antimicrobial action, synthesis, medical applications, and toxicity effects. Int Nano Lett 2:32. https://doi.org/10.1186/2228-5326-2-32
Pridgen EM, Alexis F, Farokhzad OC (2014) Polymeric nanoparticle technologies for oral drug delivery. Clin Gastroenterol Hepatol 12(10):1605–1610
Radovic-Moreno AF, Lu TK, Puscasu VA et al (2012) Surface charge-switching polymeric nanoparticles for bacterial cell wall-targeted delivery of antibiotics. ACS Nano 6:4279–4287. https://doi.org/10.1021/nn3008383
Raffi M, Mehrwan S, Bhatti TM et al (2010) Investigations into the antibacterial behavior of copper nanoparticles against Escherichia coli. Ann Microbiol 60:75–80. https://doi.org/10.1007/s13213-010-0015-6
Rai A, Prabhune A, Perry CC (2010) Antibiotic mediated synthesis of gold nanoparticles with potent antimicrobial activity and their application in antimicrobial coatings. J Mater Chem 20:6789. https://doi.org/10.1039/c0jm00817f
Rajeshkumar S, Malarkodi C (2014) In vitro antibacterial activity and mechanism of silver nanoparticles against foodborne pathogens. Bioinorg Chem Appl 2014:1–10. https://doi.org/10.1155/2014/581890
Ramalingam B, Parandhaman T, Das SK (2016) Antibacterial effects of biosynthesized silver nanoparticles on surface ultrastructure and nanomechanical properties of gram-negative bacteria viz. Escherichia coli and Pseudomonas aeruginosa. ACS Appl Mater Interfaces 8:4963–4976. https://doi.org/10.1021/acsami.6b00161
Reddy KM, Feris K, Bell J et al (2007) Selective toxicity of zinc oxide nanoparticles to prokaryotic and eukaryotic systems. Appl Phys Lett 90:213902-1–213902-3. https://doi.org/10.1063/1.2742324
Reidy B, Haase A, Luch A et al (2013) Mechanisms of silver nanoparticle release, transformation and toxicity: a critical review of current knowledge and recommendations for future studies and applications. Materials (Basel) 6:2295–2350. https://doi.org/10.3390/ma6062295
Ren G, Hu D, Cheng EWC et al (2009) Characterisation of copper oxide nanoparticles for antimicrobial applications. Int J Antimicrob Agents 33:587–590. https://doi.org/10.1016/j.ijantimicag.2008.12.004
Roshmi T, Soumya KR, Jyothis M, Radhakrishnan EK (2015) Effect of biofabricated gold nanoparticle-based antibiotic conjugates on minimum inhibitory concentration of bacterial isolates of clinical origin. Gold Bull 48:63–71. https://doi.org/10.1007/s13404-015-0162-4
Roy AS, Parveen A, Koppalkar AR, Prasad MVNA (2010) Effect of nano-titanium dioxide with different antibiotics against methicillin-resistant Staphylococcus aureus. J Biomater Nanobiotechnol 1:37–41. https://doi.org/10.4236/jbnb.2010.11005
Rudramurthy G, Swamy M, Sinniah U, Ghasemzadeh A (2016) Nanoparticles: alternatives against drug-resistant pathogenic microbes. Molecules 21:836. https://doi.org/10.3390/molecules21070836
Ruparelia JP, Chatterjee AK, Duttagupta SP, Mukherji S (2008) Strain specificity in antimicrobial activity of silver and copper nanoparticles. Acta Biomater 4:707–716. https://doi.org/10.1016/j.actbio.2007.11.006
Saliani M, Jalal R, Kafshadre Goharshadi E (2015) Effects of pH and temperature on antibacterial activity of zinc oxide nanofluid against E. coli O157:H7 and Staphylococcus aureus. Jundishapur J Microbiol 8:e17115. https://doi.org/10.5812/jjm.17115
Sametband M, Shukla S, Meningher T et al (2011) Effective multi-strain inhibition of influenza virus by anionic gold nanoparticles. Medchemcomm 2:421–423. https://doi.org/10.1039/c0md00229a
Sauvet G, Fortuniak W, Kazmierski K, Chojnowski J (2003) Amphiphilic block and statistical siloxane copolymers with antimicrobial activity. J Polym Sci Part A Polym Chem 41:2939–2948
Sawai J, Kojima H, Igarashi H et al (2000) Antibacterial characteristics of magnesium oxide powder. World J Microbiol Biotechnol 16:187–194. https://doi.org/10.1023/A:1008916209784
Schmieder R, Edwards R (2012) Insights into antibiotic resistance through metagenomic approaches. Future Microbiol 7:73–89. https://doi.org/10.2217/fmb.11.135
Sémiramoth N, C MD, Zouhiri F et al (2012) Self-assembled squalenoylated penicillin bioconjugates: an original approach for the treatment of intracellular infections. ACS Nano 6:3820–3831. https://doi.org/10.1021/nn204928v
Shareena Dasari TP, Zhang Y, Yu H (2015) Antibacterial activity and cytotoxicity of Gold (I) and (III) ions and gold nanoparticles. Biochem Pharmacol 4:289–313. https://doi.org/10.4172/2167-0501.1000199. Open Access
Sosnik A, Carcaboso ÁM, Glisoni RJ et al (2010) New old challenges in tuberculosis: potentially effective nanotechnologies in drug delivery. Adv Drug Deliv Rev 62:547–559. https://doi.org/10.1016/j.addr.2009.11.023
Su Y, Zheng X, Chen Y et al (2015) Alteration of intracellular protein expressions as a key mechanism of the deterioration of bacterial denitrification caused by copper oxide nanoparticles. Sci Rep 5:15824. https://doi.org/10.1038/srep15824
Sukhorukova IV, Sheveyko AN, Kiryukhantsev-Korneev PV et al (2015) Toward bioactive yet antibacterial surfaces. Colloids Surf B Biointerfaces 135:158–165. https://doi.org/10.1016/j.colsurfb.2015.06.059
Sun T, Hao H, Hao W et al (2014) Preparation and antibacterial properties of titanium-doped ZnO from different zinc salts. Nanoscale Res Lett 9:98. https://doi.org/10.1186/1556-276X-9-98
Swamy MK, Akhtar MS, Mohanty SK, Sinniah UR (2015) Synthesis and characterization of silver nanoparticles using fruit extract of Momordica cymbalaria and assessment of their in vitro antimicrobial, antioxidant and cytotoxicity activities. Spectrochim Acta Part A Mol Biomol Spectrosc 151:939–944. https://doi.org/10.1016/j.saa.2015.07.009
Tayel AA, El-Tras WF, Moussa S et al (2011) Antibacterial action of zinc oxide nanoparticles against foodborne pathogens. J Food Saf 31:211–218. https://doi.org/10.1111/j.1745-4565.2010.00287.x
Tiwari P, Vig K, Dennis V, Singh S (2011) Functionalized gold nanoparticles and their biomedical applications. Nano 1:31–63. https://doi.org/10.3390/nano1010031
Travan A, Pelillo C, Donati I et al (2009) Nanocomposites with antimicrobial activity. Biomacromolecules 10:1429–1435. https://doi.org/10.1021/Bm900039x
Tyler B, Gullotti D, Mangraviti A et al (2016) Polylactic acid (PLA) controlled delivery carriers for biomedical applications. Adv Drug Deliv Rev 107:163–175. https://doi.org/10.1016/j.addr.2016.06.018
Usman MS, El Zowalaty ME, Shameli K, Zainuddin N, Salama M, Ibrahim NA (2013) Synthesis, characterization, and antimicrobial properties of copper nanoparticles. Int J Nanomedicine 8:4467–4479
Voltan A, Quindós G, Alarcón K et al (2016) Fungal diseases: could nanostructured drug delivery systems be a novel paradigm for therapy? Int J Nanomedicine 11:3715–3730. https://doi.org/10.2147/IJN.S93105
Wang L, Hu C, Shao L (2017) The antimicrobial activity of nanoparticles: present situation and prospects for the future. Int J Nanomedicine 12:1227–1249. https://doi.org/10.2147/IJN.S121956
Wang J, Li S, Han Y et al (2018) Poly(Ethylene Glycol)–polylactide micelles for cancer therapy. Front Pharmacol 9:1–15. https://doi.org/10.3389/fphar.2018.00202
Wilczewska AZ, Niemirowicz K, Markiewicz KH, Car H (2012) Nanoparticles as drug delivery systems. Pharmacol Reports 64:1020–1037. https://doi.org/10.1016/S1734-1140(12)70901-5
Winnicka K, Sosnowska K, Wieczorek P et al (2011) Poly(amidoamine) dendrimers increase antifungal activity of Clotrimazole. Biol Pharm Bull 34:1129–1133. https://doi.org/10.1248/bpb.34.1129
Xie Y, He Y, Irwin PL et al (2011) Antibacterial activity and mechanism of action of zinc oxide nanoparticles against Campylobacter jejuni. Appl Environ Microbiol 77:2325–2331. https://doi.org/10.1128/AEM.02149-10
Xue Y, Xiao H, Zhang Y (2015) Antimicrobial polymeric materials with quaternary ammonium and phosphonium salts. Int J Mol Sci 16:3626–3655. https://doi.org/10.3390/ijms16023626
Yamamoto O, Ohira T, Alvarez K, Fukuda M (2010) Antibacterial characteristics of CaCO3–MgO composites. Mater Sci Eng B 173:208–212. https://doi.org/10.1016/j.mseb.2009.12.007
Yamanaka M, Hara K, Kudo J (2005) Bactericidal actions of a silver ion solution on Escherichia coli, studied by energy-filtering transmission electron microscopy and proteomic analysis. Appl Environ Microbiol 71:7589–7593. https://doi.org/10.1128/AEM.71.11.7589
Yien L, Zin NM, Sarwar A, Katas H (2012) Antifungal activity of chitosan nanoparticles and correlation with their physical properties. Int J Biomater 2012:632698
Yoo HS, Park TG (2001) Biodegradable polymeric micelles composed of doxorubicin conjugated PLGA–PEG block copolymer. J Control Release 70:63–70. https://doi.org/10.1016/S0168-3659(00)00340-0
Yudovin-Farber I, Golenser J, Beyth N et al (2010) Quaternary ammonium polyethyleneimine: antibacterial activity. J Nanomater 2010:1–11. https://doi.org/10.1155/2010/826343
Zarei M, Jamnejad A, Khajehali E (2014) Antibacterial effect of silver nanoparticles against four foodborne pathogens. Jundishapur J Microbiol 7:1–4. https://doi.org/10.5812/jjm.8720
Zawrah M, El-Moez SA, Center D (2011) Antimicrobial activities of gold nanoparticles against major foodborne pathogens. Life Sci J 8:37–44
Zhang L, Chan JM, Gu FX et al (2008) Self-assembled lipid−polymer hybrid nanoparticles: a robust drug delivery platform. ACS Nano 2:1696–1702. https://doi.org/10.1021/nn800275r
Zharov VP, Mercer KE, Galitovskaya EN, Smeltzer MS (2006) Photothermal nanotherapeutics and nanodiagnostics for selective killing of bacteria targeted with gold nanoparticles. Biophys J 90:619–627. https://doi.org/10.1529/biophysj.105.061895
Zhou Y, Kong Y, Kundu S et al (2012) Antibacterial activities of gold and silver nanoparticles against Escherichia coli and bacillus Calmette-Guérin. J Nanobiotechnol 10:19. https://doi.org/10.1186/1477-3155-10-19
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Chattopadhyay, I. (2020). Application of Nanoparticles in Drug Delivery. In: Siddhardha, B., Dyavaiah, M., Kasinathan, K. (eds) Model Organisms to Study Biological Activities and Toxicity of Nanoparticles. Springer, Singapore. https://doi.org/10.1007/978-981-15-1702-0_3
Download citation
DOI: https://doi.org/10.1007/978-981-15-1702-0_3
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-15-1701-3
Online ISBN: 978-981-15-1702-0
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)