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Nanozymes: Biomedical Applications of Enzymatic Fe3O4 Nanoparticles from In Vitro to In Vivo

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Biological and Bio-inspired Nanomaterials

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1174))

Abstract

Fe3O4, also called magnetite, is a naturally occurring mineral and has been widely used in biomedical applications. However, in the past, all the applications were based on its excellent magnetic properties and neglected its catalytic properties. In 2007, we found that Fe3O4 nanoparticles are able to perform intrinsic enzyme-like activities. A specific term, “nanozyme”, is used to describe the new property of intrinsic enzymatic activity of nanomaterials. Since then, Fe3O4 nanoparticles have been used as enzyme mimics, which broadens their applications beyond simply their magnetic properties, with applications in biomedical diagnosis and therapy, environmental monitoring and treatment, the food industry and chemical synthesis. In this chapter, we will summarize the basic features of Fe3O4 as an enzyme mimetic and its applications in biomedicine.

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Abbreviations

ABTS:

2, 2′-azino-bis (3-ethylbenzthiazoline-6-sulfonic acid)

AD:

Alzheimer’s disease

APTES:

3-Aminopropyltriethoxysilane

CNT:

Carbon nanotube

DAB:

3, 3′-Diaminobenzidine

EBOV:

Ebola virus

EPR:

Enhanced permeability and retention

Fe3O4 :

Magnetite or iron oxide

GO:

Graphene oxide

GOx:

Glucose oxidase

H2O2 :

Hydrogen peroxide

HCG:

Human chorionic gonadotropin

HFn:

Human heavy-chain ferritin

HRP:

Horseradish peroxidase

M-HFn:

Magnetoferritin nanoparticles

MNPs:

Magnetic nanoparticles

MRI:

Magnetic resonance imaging

MRSA:

Staphylococcus aureus

NPs:

Nanoparticles

NTs:

Nanotubes

NWs:

Nanowires

OPD:

o-phenylenediamine

PD:

Parkinson’s disease

PEG:

Polyethylene glycol

RES:

Reticuloendothelial system

RGO:

Reduced graphene oxide

ROS:

Reactive oxygen species

TMB:

3, 3′, 5, 5′-Tetramethylbenzidine

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Acknowledgement

This work was supported in part by the Foundation of the Thousand Talents Plan for Young Professionals and Jiangsu Specially-Appointed Professor, the Interdisciplinary Funding at Yangzhou University, Strategic Priority Research Program of the Chinese Academy of Sciences (Grant No. XDA09030306), National Natural Science Foundation of China (Grant No. 31530026 and 81671810), Natural Science Foundation of Jiangsu (Grant No. BK20161333).

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Authors and Affiliations

  1. Institute of Translational Medicine, School of Medicine, Yangzhou University, Yangzhou, Jangsu, China

    Lizeng Gao

  2. Key Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

    Xiyun Yan

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  1. Lizeng Gao
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  2. Xiyun Yan
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Correspondence to Xiyun Yan .

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Editors and Affiliations

  1. National Laboratory of Biomacromolecules, Institute of Biophysics Chinese Academy of Sciences, Beijing, China

    Sarah Perrett

  2. Department of Biotechnology and Biomedicine, Technical University of Denmark DTU, Lyngby, Denmark

    Alexander K. Buell

  3. Department of Chemistry, University of Cambridge, Cambridge, UK

    Tuomas P.J. Knowles

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Gao, L., Yan, X. (2019). Nanozymes: Biomedical Applications of Enzymatic Fe3O4 Nanoparticles from In Vitro to In Vivo. In: Perrett, S., Buell, A., Knowles, T. (eds) Biological and Bio-inspired Nanomaterials. Advances in Experimental Medicine and Biology, vol 1174. Springer, Singapore. https://doi.org/10.1007/978-981-13-9791-2_9

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