Abstract
The growth arrest and DNA damage-inducible (Gadd) 45 proteins have been associated with numerous cellular mechanisms including cell cycle control, DNA damage sensation and repair, genotoxic stress, neoplasia, and molecular epigenetics. The genes were originally identified in in vitro screens of irradiation- and interleukin-induced transcription and have since been implicated in a host of normal and aberrant central nervous system processes. These include early and postnatal development, injury, cancer, memory, aging, and neurodegenerative and psychiatric disease states. The proteins act through a variety of molecular signaling cascades including the MAPK cascade, cell cycle control mechanisms, histone regulation, and epigenetic DNA demethylation. In this review, we provide a comprehensive discussion of the literature implicating each of the three members of the Gadd45 family in these processes.
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Acknowledgments
The authors wish to thank Pr J. David Sweat for his help with the initial chapter and his continuous unlimited unconditional support. This work is supported by an NIH-NIA grant AG054411 awarded to BES.
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Sultan, F.A., Sawaya, B.E. (2022). Gadd45 in Neuronal Development, Function, and Injury. In: Zaidi, M.R., Liebermann, D.A. (eds) Gadd45 Stress Sensor Genes. Advances in Experimental Medicine and Biology, vol 1360. Springer, Cham. https://doi.org/10.1007/978-3-030-94804-7_9
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