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Geroprotective Effects of Activation of D-GADD45 DNA Reparation Gene in Drosophila Melanogaster Nervous System

  • Genetics
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Bulletin of Experimental Biology and Medicine Aims and scope

The expre ssion of D-GADD45 gene involved in DNA reparation in Drosophila melanogaster decreases with age. Overexpression of D-GADD45 in the drosophila nervous system prolongs the median and maximum life span without deterioration of the quality of life parameters (fertility and neuromuscular activity). The life span prolongation effect is due to more effective DNA reparation, as spontaneous level of DNA aberrations in the nerve tissue of larvae with D-GADD45 overexpression is reduced signifi cantly.

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Authors and Affiliations

  1. Institute of Biology, Komi Research Center, Ural Division of the Russian Academy of Sciences, Syktyvkar, Russia

    E. N. Plyusnina, M. V. Shaposhnikov & A. A. Moskalev

Authors
  1. E. N. Plyusnina
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  2. M. V. Shaposhnikov
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  3. A. A. Moskalev
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Correspondence to A. A. Moskalev.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 152, No. 9, pp. 310-313, September, 2011

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Plyusnina, E.N., Shaposhnikov, M.V. & Moskalev, A.A. Geroprotective Effects of Activation of D-GADD45 DNA Reparation Gene in Drosophila Melanogaster Nervous System. Bull Exp Biol Med 152, 340–343 (2012). https://doi.org/10.1007/s10517-012-1523-0

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  • DOI: https://doi.org/10.1007/s10517-012-1523-0

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