Overview
- Provides a comprehensive picture of the unique global role Gadd45 genes plays
- Interest in Gadd45 stress signaling is exponentially increasing
- Gadd45 stress signaling modulate a wide range of normal & abnormal biological phenomena
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1360)
Access this book
Tax calculation will be finalised at checkout
Other ways to access
Table of contents (9 chapters)
-
Front Matter
-
Back Matter
Keywords
About this book
This second edition is fully updated throughout and covers the emerging evidence that indicates that the Gadd45 family of proteins plays a unique and critical role as sensors of stress, including genotoxic, physiological, and oncogenic stress. It sheds light on the complex cellular stress response, encompassing myriad molecular pathways with a plethora of regulators and effectors.
The GADD45 stress response genes encode small (18 kd) nuclear/cytoplasmic proteins. These genes are rapidly induced by a wide variety of endogenous and exogenous stress stimuli. Despite marked similarities, Gadd45 genes are regulated differentially and exhibit functional diversity. Gadd45 proteins respond to physiological and oncogenic stress, and are implicated in cell cycle arrest, DNA demethylation and repair, apoptosis, cell survival, genomic stability, and inflammation.
The purpose of this book is to provide a comprehensive overview of the unique global role that Gadd45proteins play as stress sensors and the molecular pathways involved.
Editors and Affiliations
About the editors
Dan Liebermann received a PhD degree in cancer genetics at the Weizmann Institute, Rehovoth, Israel. His postdoctoral training was at the Stanford University School of Medicine (1980-1985). He started his independent research career at the University of Pennsylvania in 1985. He moved to Temple University School of Medicine in 1993, where he is currently a Professor of Cancer and Cellular Biology and the Fels Cancer Institute for Personalized Medicine in Philadelphia, Pennsylvania. The central theme of his research program has been elucidating the molecular mechanisms that govern normal cell development and carcinogenesis, notably blood cell development, inflammation, leukemogenesis, and breast carcinogenesis. He has made major contributions in the area of hematopoietic cell differentiation, identifying and characterizing myeloid differentiation (MyD) primary response genes, which play important roles in terminal differentiation of hematopoietic cells. He has made discoveries of several novel genes, including the GADD45 family of stress response genes.
Bibliographic Information
Book Title: Gadd45 Stress Sensor Genes
Editors: M. Raza Zaidi, Dan A. Liebermann
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-3-030-94804-7
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022
Hardcover ISBN: 978-3-030-94803-0Published: 04 May 2022
Softcover ISBN: 978-3-030-94806-1Published: 05 May 2023
eBook ISBN: 978-3-030-94804-7Published: 04 May 2022
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 2
Number of Pages: IX, 153
Number of Illustrations: 9 b/w illustrations, 18 illustrations in colour
Topics: Gene Function, Human Genetics, Microbial Genetics and Genomics