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Hematogenous Osteomyelitis and Septic Arthritis in Children

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Evidence-Based Imaging in Pediatrics

Part of the book series: Evidence-Based Imaging ((Evidence-Based Imag.))

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Abstract

What is the diagnostic performance of the different imaging studies in acute hematogenous osteomyelitis (AHOM) in children?

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References

  1. Whyte NS, Bielski RJ. Acute hematogenous osteomyelitis in children. Pediatr Ann. 2016;45(6):e204–8. https://doi.org/10.3928/00904481-20160428-01.

    Article  PubMed  Google Scholar 

  2. Stephen RF, Benson MK, Nade S. Misconceptions about childhood acute osteomyelitis. J Child Orthop. 2012;6(5):353–6. https://doi.org/10.1007/s11832-012-0435-x.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Yeo A, Ramachandran M. Acute haematogenous osteomyelitis in children [published correction appears in BMJ. 2014;348:1326]. BMJ. 2014;348:g66. Published 2014 Jan 20. https://doi.org/10.1136/bmj.g66.

    Article  PubMed  Google Scholar 

  4. Frank G, Mahoney HM, Eppes SC. Musculoskeletal infections in children. Pediatr Clin N Am. 2005;52(4):1083–ix. https://doi.org/10.1016/j.pcl.2005.04.003.

    Article  Google Scholar 

  5. Davies AM, Grimer R. The penumbra sign in subacute osteomyelitis. Eur Radiol. 2005;15(6):1268–70. https://doi.org/10.1007/s00330-004-2435-9.

    Article  CAS  PubMed  Google Scholar 

  6. McGuinness B, Wilson N, Doyle AJ. The “penumbra sign” on T1-weighted MRI for differentiating musculoskeletal infection from tumour. Skelet Radiol. 2007;36(5):417–21. https://doi.org/10.1007/s00256-006-0267-1.

    Article  CAS  Google Scholar 

  7. Pineda C, Vargas A, Rodríguez AV. Imaging of osteomyelitis: current concepts. Infect Dis Clin N Am. 2006;20(4):789–825. https://doi.org/10.1016/j.idc.2006.09.009.

    Article  Google Scholar 

  8. Oudjhane K, Azouz EM. Imaging of osteomyelitis in children. Radiol Clin N Am. 2001;39(2):251–66. https://doi.org/10.1016/s0033-8389(05)70276-1.

    Article  CAS  PubMed  Google Scholar 

  9. Mantero E, Carbone M, Calevo MG, Boero S. Diagnosis and treatment of pediatric chronic osteomyelitis in developing countries: prospective study of 96 patients treated in Kenya. Musculoskelet Surg. 2011;95(1):13–8. https://doi.org/10.1007/s12306-011-0104-0.

    Article  CAS  PubMed  Google Scholar 

  10. Lee YJ, Sadigh S, Mankad K, Kapse N, Rajeswaran G. The imaging of osteomyelitis. Quant Imaging Med Surg. 2016;6(2):184–98. https://doi.org/10.21037/qims.2016.04.01.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Ogden JA. Pediatric osteomyelitis and septic arthritis: the pathology of neonatal disease. Yale J Biol Med. 1979;52(5):423–48.

    CAS  PubMed  PubMed Central  Google Scholar 

  12. Offiah AC. Acute osteomyelitis, septic arthritis and discitis: differences between neonates and older children. Eur J Radiol. 2006;60(2):221–32. https://doi.org/10.1016/j.ejrad.2006.07.016.

    Article  CAS  PubMed  Google Scholar 

  13. Gilbertson-Dahdal D, Wright JE, Krupinski E, McCurdy WE, Taljanovic MS. Transphyseal involvement of pyogenic osteomyelitis is considerably more common than classically taught. AJR Am J Roentgenol. 2014;203(1):190–5. https://doi.org/10.2214/AJR.13.11279.

    Article  PubMed  Google Scholar 

  14. Peltola H, Pääkkönen M. Acute osteomyelitis in children. N Engl J Med. 2014;370(4):352–60. https://doi.org/10.1056/NEJMra1213956.

    Article  CAS  PubMed  Google Scholar 

  15. Gafur OA, Copley LA, Hollmig ST, Browne RH, Thornton LA, Crawford SE. The impact of the current epidemiology of pediatric musculoskeletal infection on evaluation and treatment guidelines. J Pediatr Orthop. 2008;28(7):777–85. https://doi.org/10.1097/BPO.0b013e318186eb4b.

    Article  PubMed  Google Scholar 

  16. Martínez-Aguilar G, Avalos-Mishaan A, Hulten K, Hammerman W, Mason EO Jr, Kaplan SL. Community-acquired, methicillin-resistant and methicillin-susceptible Staphylococcus aureus musculoskeletal infections in children. Pediatr Infect Dis J. 2004;23(8):701–6.

    Article  PubMed  Google Scholar 

  17. Castellazzi L, Mantero M, Esposito S. Update on the management of pediatric acute osteomyelitis and septic arthritis. Int J Mol Sci. 2016;17(6):855. Published 2016 Jun 1. https://doi.org/10.3390/ijms17060855.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Dohin B, Gillet Y, Kohler R, et al. Pediatric bone and joint infections caused by Panton-Valentine leukocidin-positive Staphylococcus aureus. Pediatr Infect Dis J. 2007;26(11):1042–8. https://doi.org/10.1097/INF.0b013e318133a85e.

    Article  PubMed  Google Scholar 

  19. Sheikh HQ, Aqil A, Kirby A, Hossain FS. Panton-Valentine leukocidin osteomyelitis in children: a growing threat. Br J Hosp Med (Lond). 2015;76(1):18–24. https://doi.org/10.12968/hmed.2015.76.1.18.

    Article  PubMed  Google Scholar 

  20. Dodwell ER. Osteomyelitis and septic arthritis in children: current concepts. Curr Opin Pediatr. 2013;25(1):58–63. https://doi.org/10.1097/MOP.0b013e32835c2b42.

    Article  CAS  PubMed  Google Scholar 

  21. Nguyen A, Kan JH, Bisset G, Rosenfeld S. Kocher criteria revisited in the era of MRI: how often does the Kocher criteria identify underlying osteomyelitis? J Pediatr Orthop. 2017;37(2):e114–9. https://doi.org/10.1097/BPO.0000000000000602.

    Article  PubMed  Google Scholar 

  22. Rosenfeld S, Bernstein DT, Daram S, Dawson J, Zhang W. Predicting the presence of adjacent infections in septic arthritis in children. J Pediatr Orthop. 2016;36(1):70–4. https://doi.org/10.1097/BPO.0000000000000389.

    Article  PubMed  Google Scholar 

  23. Montgomery NI, Epps HR. Pediatric septic arthritis. Orthop Clin North Am. 2017;48(2):209–16. https://doi.org/10.1016/j.ocl.2016.12.008.

    Article  PubMed  Google Scholar 

  24. Kocher MS, Mandiga R, Zurakowski D, Barnewolt C, Kasser JR. Validation of a clinical prediction rule for the differentiation between septic arthritis and transient synovitis of the hip in children. J Bone Joint Surg Am. 2004;86(8):1629–35. https://doi.org/10.2106/00004623-200408000-00005.

    Article  PubMed  Google Scholar 

  25. Caird MS, Flynn JM, Leung YL, Millman JE, D’Italia JG, Dormans JP. Factors distinguishing septic arthritis from transient synovitis of the hip in children. A prospective study. J Bone Joint Surg Am. 2006;88(6):1251–7. https://doi.org/10.2106/JBJS.E.00216.

    Article  PubMed  Google Scholar 

  26. Zawin JK, Hoffer FA, Rand FF, Teele RL. Joint effusion in children with an irritable hip: US diagnosis and aspiration. Radiology. 1993;187(2):459–63. https://doi.org/10.1148/radiology.187.2.8475290.

    Article  CAS  PubMed  Google Scholar 

  27. Zamzam MM. The role of ultrasound in differentiating septic arthritis from transient synovitis of the hip in children. J Pediatr Orthop B. 2006;15(6):418–22. https://doi.org/10.1097/01.bpb.0000228388.32184.7f.

    Article  PubMed  Google Scholar 

  28. Miralles M, Gonzalez G, Pulpeiro JR, et al. Sonography of the painful hip in children: 500 consecutive cases. AJR Am J Roentgenol. 1989;152(3):579–82. https://doi.org/10.2214/ajr.152.3.579.

    Article  CAS  PubMed  Google Scholar 

  29. Gordon JE, Huang M, Dobbs M, Luhmann SJ, Szymanski DA, Schoenecker PL. Causes of false-negative ultrasound scans in the diagnosis of septic arthritis of the hip in children. J Pediatr Orthop. 2002;22(3):312–6.

    Article  PubMed  Google Scholar 

  30. Arnold JC, Bradley JS. Osteoarticular infections in children. Infect Dis Clin N Am. 2015;29(3):557–74. https://doi.org/10.1016/j.idc.2015.05.012.

    Article  Google Scholar 

  31. Blickman JG, van Die CE, de Rooy JW. Current imaging concepts in pediatric osteomyelitis. Eur Radiol. 2004;14(Suppl 4):L55–64. https://doi.org/10.1007/s00330-003-2032-3.

    Article  PubMed  Google Scholar 

  32. Steer AC, Carapetis JR. Acute hematogenous osteomyelitis in children: recognition and management. Paediatr Drugs. 2004;6(6):333–46. https://doi.org/10.2165/00148581-200406060-00002.

    Article  PubMed  Google Scholar 

  33. Nelson JD, Norden C, Mader JT, Calandra GB. Evaluation of new anti-infective drugs for the treatment of acute hematogenous osteomyelitis in children. Infectious Diseases Society of America and the Food and Drug Administration. Clin Infect Dis. 1992;15(Suppl 1):S162–6. https://doi.org/10.1093/clind/15.supplement_1.s162.

    Article  PubMed  Google Scholar 

  34. McPherson DM. Osteomyelitis in the neonate. Neonatal Netw. 2002;21(1):9–22. https://doi.org/10.1891/0730-0832.21.1.9.

    Article  PubMed  Google Scholar 

  35. Asmar BI. Osteomyelitis in the neonate. Infect Dis Clin N Am. 1992;6(1):117–32.

    Article  CAS  Google Scholar 

  36. Dormans JP, Drummond DS. Pediatric hematogenous osteomyelitis: new trends in presentation, diagnosis, and treatment. J Am Acad Orthop Surg. 1994;2(6):333–41. https://doi.org/10.5435/00124635-199411000-00005.

    Article  CAS  PubMed  Google Scholar 

  37. Howard CB, Einhorn M, Dagan R, Yagupski P, Porat S. Fine-needle bone biopsy to diagnose osteomyelitis. J Bone Joint Surg Br. 1994;76(2):311–4.

    Article  CAS  PubMed  Google Scholar 

  38. Caksen H, Oztürk MK, Uzüm K, Yüksel S, Ustünbaş HB, Per H. Septic arthritis in childhood. Pediatr Int. 2000;42(5):534–40. https://doi.org/10.1046/j.1442-200x.2000.01267.x.

    Article  CAS  PubMed  Google Scholar 

  39. Perlman MH, Patzakis MJ, Kumar PJ, Holtom P. The incidence of joint involvement with adjacent osteomyelitis in pediatric patients. J Pediatr Orthop. 2000;20(1):40–3.

    Article  CAS  PubMed  Google Scholar 

  40. Wang CL, Wang SM, Yang YJ, Tsai CH, Liu CC. Septic arthritis in children: relationship of causative pathogens, complications, and outcome. J Microbiol Immunol Infect. 2003;36(1):41–6.

    PubMed  Google Scholar 

  41. Unkila-Kallio L, Kallio MJ, Peltola H. Acute haematogenous osteomyelitis in children in Finland. Finnish Study Group. Ann Med. 1993;25(6):545–9.

    Article  CAS  PubMed  Google Scholar 

  42. Malcius D, Jonkus M, Kuprionis G, et al. The accuracy of different imaging techniques in diagnosis of acute hematogenous osteomyelitis. Medicina (Kaunas). 2009;45(8):624–31.

    Article  PubMed  Google Scholar 

  43. Faden H, Grossi M. Acute osteomyelitis in children. Reassessment of etiologic agents and their clinical characteristics. Am J Dis Child. 1991;145(1):65–9. https://doi.org/10.1001/archpedi.1991.02160010071018.

    Article  CAS  PubMed  Google Scholar 

  44. Kao HC, Huang YC, Chiu CH, et al. Acute hematogenous osteomyelitis and septic arthritis in children. J Microbiol Immunol Infect. 2003;36(4):260–5.

    PubMed  Google Scholar 

  45. Bonakdar-pour A, Gaines VD. The radiology of osteomyelitis. Orthop Clin North Am. 1983;14(1):21–37.

    Article  CAS  PubMed  Google Scholar 

  46. Jaramillo D, Treves ST, Kasser JR, Harper M, Sundel R, Laor T. Osteomyelitis and septic arthritis in children: appropriate use of imaging to guide treatment. AJR Am J Roentgenol. 1995;165(2):399–403. https://doi.org/10.2214/ajr.165.2.7618566.

    Article  CAS  PubMed  Google Scholar 

  47. Gold R. Radiographic diagnosis of osteomyelitis. Pediatr Infect Dis J. 1995;14(6):555. https://doi.org/10.1097/00006454-199506000-00022.

    Article  CAS  PubMed  Google Scholar 

  48. Kaye JJ. Roentgenographic evaluation of children with acute onset of a limp. Pediatr Ann. 1976;5(1):11–31. https://doi.org/10.3928/0090-4481-19760101-04.

    Article  CAS  PubMed  Google Scholar 

  49. Capitanio MA, Kirkpatrick JA. Early roentgen observations in acute osteomyelitis. Am J Roentgenol Radium Therapy, Nucl Med. 1970;108(3):488–96. https://doi.org/10.2214/ajr.108.3.488.

    Article  CAS  Google Scholar 

  50. Mazur JM, Ross G, Cummings J, Hahn GA Jr, McCluskey WP. Usefulness of magnetic resonance imaging for the diagnosis of acute musculoskeletal infections in children. J Pediatr Orthop. 1995;15(2):144–7.

    Article  CAS  PubMed  Google Scholar 

  51. Zadig P, von Brandis E, Lein RK, Rosendahl K, Avenarius D, Ording Müller LS. Whole-body magnetic resonance imaging in children – how and why? A systematic review [published online ahead of print, 2020 Jun 25]. Pediatr Radiol. 2020; https://doi.org/10.1007/s00247-020-04735-9.

  52. Darge K, Jaramillo D, Siegel MJ. Whole-body MRI in children: current status and future applications. Eur J Radiol. 2008;68(2):289–98. https://doi.org/10.1016/j.ejrad.2008.05.018.

    Article  PubMed  Google Scholar 

  53. Connolly LP, Connolly SA, Drubach LA, Jaramillo D, Treves ST. Acute hematogenous osteomyelitis of children: assessment of skeletal scintigraphy-based diagnosis in the era of MRI. J Nucl Med. 2002;43(10):1310–6.

    PubMed  Google Scholar 

  54. DiPoce J, Jbara ME, Brenner AI. Pediatric osteomyelitis: a scintigraphic case-based review. Radiographics. 2012;32(3):865–78. https://doi.org/10.1148/rg.323115110.

    Article  PubMed  Google Scholar 

  55. Miller R, Beck NA, Sampson NR, Zhu X, Flynn JM, Drummond D. Imaging modalities for low back pain in children: a review of spondyloysis and undiagnosed mechanical back pain. J Pediatr Orthop. 2013;33(3):282–8. https://doi.org/10.1097/BPO.0b013e318287fffb.

    Article  PubMed  Google Scholar 

  56. Morrison WB, Schweitzer ME, Bock GW, et al. Diagnosis of osteomyelitis: utility of fat-suppressed contrast-enhanced MR imaging. Radiology. 1993;189(1):251–7. https://doi.org/10.1148/radiology.189.1.8204132.

    Article  CAS  PubMed  Google Scholar 

  57. Sullivan DC, Rosenfield NS, Ogden J, Gottschalk A. Problems in the scintigraphic detection of osteomyelitis in children. Radiology. 1980;135(3):731–6. https://doi.org/10.1148/radiology.135.3.7384463.

    Article  CAS  PubMed  Google Scholar 

  58. Berkowitz ID, Wenzel W. ‘Normal’ technetium bone scans in patients with acute osteomyelitis. Am J Dis Child. 1980;134(9):828–30. https://doi.org/10.1001/archpedi.1980.02130210012004.

    Article  CAS  PubMed  Google Scholar 

  59. Handmaker H. Acute hematogenous osteomyelitis: has the bone scan betrayed us? Radiology. 1980;135(3):787–9. https://doi.org/10.1148/radiology.135.3.7384478.

    Article  CAS  PubMed  Google Scholar 

  60. Park HM, Rothschild PA, Kernek CB. Scintigraphic evaluation of extremity pain in children: its efficacy and pitfalls. AJR Am J Roentgenol. 1985;145(5):1079–84. https://doi.org/10.2214/ajr.145.5.1079.

    Article  CAS  PubMed  Google Scholar 

  61. Jaramillo D, Dormans JP, Delgado J, Laor T, St Geme JW 3rd. Hematogenous osteomyelitis in infants and children: imaging of a changing disease. Radiology. 2017;283(3):629–43. https://doi.org/10.1148/radiol.2017151929.

    Article  PubMed  Google Scholar 

  62. Browne LP, Guillerman RP, Orth RC, Patel J, Mason EO, Kaplan SL. Community-acquired staphylococcal musculoskeletal infection in infants and young children: necessity of contrast-enhanced MRI for the diagnosis of growth cartilage involvement. AJR Am J Roentgenol. 2012;198(1):194–9. https://doi.org/10.2214/AJR.10.5730.

    Article  PubMed  Google Scholar 

  63. Belthur MV, Birchansky SB, Verdugo AA, et al. Pathologic fractures in children with acute Staphylococcus aureus osteomyelitis. J Bone Joint Surg Am. 2012;94(1):34–42. https://doi.org/10.2106/JBJS.J.01915.

    Article  PubMed  Google Scholar 

  64. Fletcher BD, Scoles PV, Nelson AD. Osteomyelitis in children: detection by magnetic resonance. Work in progress. Radiology. 1984;150(1):57–60. https://doi.org/10.1148/radiology.150.1.6689788.

    Article  CAS  PubMed  Google Scholar 

  65. Berquist TH, Brown ML, Fitzgerald RH Jr, May GR. Magnetic resonance imaging: application in musculoskeletal infection. Magn Reson Imaging. 1985;3(3):219–30. https://doi.org/10.1016/0730-725x(85)90350-9.

    Article  CAS  PubMed  Google Scholar 

  66. Dangman BC, Hoffer FA, Rand FF, O’Rourke EJ. Osteomyelitis in children: gadolinium-enhanced MR imaging. Radiology. 1992;182(3):743–7. https://doi.org/10.1148/radiology.182.3.1535888.

    Article  CAS  PubMed  Google Scholar 

  67. Henninger B, Glodny B, Rudisch A, et al. Ewing sarcoma versus osteomyelitis: differential diagnosis with magnetic resonance imaging. Skelet Radiol. 2013;42(8):1097–104. https://doi.org/10.1007/s00256-013-1632-5.

    Article  CAS  Google Scholar 

  68. Arkader A, Glotzbecker M, Hosalkar HS, Dormans JP. Primary musculoskeletal Langerhans cell histiocytosis in children: an analysis for a 3-decade period. J Pediatr Orthop. 2009;29(2):201–7. https://doi.org/10.1097/BPO.0b013e3181982aa2.

    Article  PubMed  Google Scholar 

  69. Laor T, Jaramillo D. MR imaging insights into skeletal maturation: what is normal? Radiology. 2009;250(1):28–38. https://doi.org/10.1148/radiol.2501071322.

    Article  PubMed  Google Scholar 

  70. Ceroni D, Belaieff W, Cherkaoui A, et al. Primary epiphyseal or apophyseal subacute osteomyelitis in the pediatric population: a report of fourteen cases and a systematic review of the literature. J Bone Joint Surg Am. 2014;96(18):1570–5. https://doi.org/10.2106/JBJS.M.00791.

    Article  PubMed  Google Scholar 

  71. Khanna G, Sato TS, Ferguson P. Imaging of chronic recurrent multifocal osteomyelitis. Radiographics. 2009;29(4):1159–77. https://doi.org/10.1148/rg.294085244.

    Article  PubMed  Google Scholar 

  72. Falip C, Alison M, Boutry N, et al. Chronic recurrent multifocal osteomyelitis (CRMO): a longitudinal case series review. Pediatr Radiol. 2013;43(3):355–75. https://doi.org/10.1007/s00247-012-2544-6.

    Article  PubMed  Google Scholar 

  73. Acikgoz G, Averill LW. Chronic recurrent multifocal osteomyelitis: typical patterns of bone involvement in whole-body bone scintigraphy. Nucl Med Commun. 2014;35(8):797–807. https://doi.org/10.1097/MNM.0000000000000126.

    Article  PubMed  Google Scholar 

  74. von Kalle T, Heim N, Hospach T, Langendörfer M, Winkler P, Stuber T. Typical patterns of bone involvement in whole-body MRI of patients with chronic recurrent multifocal osteomyelitis (CRMO). Rofo. 2013;185(7):655–61. https://doi.org/10.1055/s-0033-1335283.

    Article  Google Scholar 

  75. Hedrich CM, Hofmann SR, Pablik J, Morbach H, Girschick HJ. Autoinflammatory bone disorders with special focus on chronic recurrent multifocal osteomyelitis (CRMO). Pediatr Rheumatol Online J. 2013;11(1):47. Published 2013 Dec 23. https://doi.org/10.1186/1546-0096-11-47.

    Article  PubMed  PubMed Central  Google Scholar 

  76. Jansson AF, Müller TH, Gliera L, et al. Clinical score for nonbacterial osteitis in children and adults. Arthritis Rheum. 2009;60(4):1152–9. https://doi.org/10.1002/art.24402.

    Article  PubMed  Google Scholar 

  77. Gonzalez BE, Teruya J, Mahoney DH Jr, et al. Venous thrombosis associated with staphylococcal osteomyelitis in children. Pediatrics. 2006;117(5):1673–9. https://doi.org/10.1542/peds.2005-2009.

    Article  PubMed  Google Scholar 

  78. Guillerman RP. Osteomyelitis and beyond. Pediatr Radiol. 2013;43(Suppl 1):S193–203. https://doi.org/10.1007/s00247-012-2594-9.

    Article  PubMed  Google Scholar 

  79. Wardak E, Gill S, Wardak M, et al. Role of MRI in detecting early physeal changes due to acute osteoarticular infection around the knee joint: a pilot study. Int Orthop. 2009;33(6):1707–11. https://doi.org/10.1007/s00264-008-0625-9.

    Article  PubMed  Google Scholar 

  80. Jäger HJ, Schmitz-Stolbrink A, Götz GF, Roggenkamp K, Mathias KD. Invasion of the growth plate by bone tumors and osteomyelitis in childhood [in German]. Radiologe. 1995;35(6):409–13.

    PubMed  Google Scholar 

  81. Duszynski DO, Kuhn JP, Afshani E, Riddlesberger MM Jr. Early radionuclide diagnosis of acute osteomyelitis. Radiology. 1975;117(2):337–40. https://doi.org/10.1148/117.2.337.

    Article  CAS  PubMed  Google Scholar 

  82. Gelfand MJ, Silberstein EB. Radionuclide imaging. Use in diagnosis of osteomyelitis in children. JAMA. 1977;237(3):245–7. https://doi.org/10.1001/jama.237.3.245.

    Article  CAS  PubMed  Google Scholar 

  83. Hankins JH, Flowers WM Jr. Radiologic seminar CLXXVII: radionuclide bone scanning in the diagnosis of acute osteomyelitis. J Miss State Med Assoc. 1978;19(1):10–2.

    CAS  PubMed  Google Scholar 

  84. Nelson HT, Taylor A. Bone scanning in the diagnosis of acute osteomyelitis. Eur J Nucl Med. 1980;5(3):267–9. https://doi.org/10.1007/BF00271910.

    Article  CAS  PubMed  Google Scholar 

  85. Erasmie U, Hirsch G. Acute haematogenous osteomyelitis in children - the reliability of skeletal scintigraphy. Z Kinderchir. 1981;32(4):360–6. https://doi.org/10.1055/s-2008-1063285.

    Article  CAS  PubMed  Google Scholar 

  86. Barron BJ, Dhekne RD. Cold osteomyelitis. Radionuclide bone scan findings. Clin Nucl Med. 1984;9(7):392–3. https://doi.org/10.1097/00003072-198407000-00005.

    Article  CAS  PubMed  Google Scholar 

  87. Ash JM, Gilday DL. The futility of bone scanning in neonatal osteomyelitis: concise communication. Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine. 1980;21(5):417–20.

    CAS  PubMed  Google Scholar 

  88. Bressler EL, Conway JJ, Weiss SC. Neonatal osteomyelitis examined by bone scintigraphy. Radiology. 1984;152(3):685–8. https://doi.org/10.1148/radiology.152.3.6463248.

    Article  CAS  PubMed  Google Scholar 

  89. Averill LW, Hernandez A, Gonzalez L, Peña AH, Jaramillo D. Diagnosis of osteomyelitis in children: utility of fat-suppressed contrast-enhanced MRI. AJR Am J Roentgenol. 2009;192(5):1232–8. https://doi.org/10.2214/AJR.07.3400.

    Article  PubMed  Google Scholar 

  90. Mattis TA, Borders HL, Ellinger DM, Junewick JJ. Relationship between the clinical characteristics of osteomyelitis and the finding of extraosseous fat on MRI in pediatric patients. Pediatr Radiol. 2011;41(10):1293–7. https://doi.org/10.1007/s00247-011-2073-8.

    Article  PubMed  Google Scholar 

  91. Abiri MM, Kirpekar M, Ablow RC. Osteomyelitis: detection with US. Radiology. 1989;172(2):509–11. https://doi.org/10.1148/radiology.172.2.2664872.

    Article  CAS  PubMed  Google Scholar 

  92. Azam Q, Ahmad I, Abbas M, Syed A, Haque F. Ultrasound and colour Doppler sonography in acute osteomyelitis in children. Acta Orthop Belg. 2005;71(5):590–6.

    PubMed  Google Scholar 

  93. Riebel TW, Nasir R, Nazarenko O. The value of sonography in the detection of osteomyelitis. Pediatr Radiol. 1996;26(4):291–7. https://doi.org/10.1007/BF01372116.

    Article  CAS  PubMed  Google Scholar 

  94. Nath AK, Sethu AU. Use of ultrasound in osteomyelitis. Br J Radiol. 1992;65(776):649–52. https://doi.org/10.1259/0007-1285-65-776-649.

    Article  CAS  PubMed  Google Scholar 

  95. Mah ET, LeQuesne GW, Gent RJ, Paterson DC. Ultrasonic features of acute osteomyelitis in children. J Bone Joint Surg Br. 1994;76(6):969–74.

    Article  CAS  PubMed  Google Scholar 

  96. Cardinal E, Bureau NJ, Aubin B, Chhem RK. Role of ultrasound in musculoskeletal infections. Radiol Clin N Am. 2001;39(2):191–201. https://doi.org/10.1016/s0033-8389(05)70272-4.

    Article  CAS  PubMed  Google Scholar 

  97. Howard CB, Einhorn M, Dagan R, Nyska M. Ultrasound in diagnosis and management of acute haematogenous osteomyelitis in children. J Bone Joint Surg Br. 1993;75(1):79–82. https://doi.org/10.1302/0301-620X.75B1.8421042.

    Article  CAS  PubMed  Google Scholar 

  98. Chao HC, Lin SJ, Huang YC, Lin TY. Color Doppler ultrasonographic evaluation of osteomyelitis in children. J Ultrasound Med. 1999;18(11):729–36. https://doi.org/10.7863/jum.1999.18.11.729.

    Article  CAS  PubMed  Google Scholar 

  99. Inusa BP, Oyewo A, Brokke F, Santhikumaran G, Jogeesvaran KH. Dilemma in differentiating between acute osteomyelitis and bone infarction in children with sickle cell disease: the role of ultrasound. PLoS One. 2013;8(6):e65001. Published 2013 Jun 6. https://doi.org/10.1371/journal.pone.0065001.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  100. Kaiser S, Jorulf H, Hirsch G. Clinical value of imaging techniques in childhood osteomyelitis. Acta Radiol. 1998;39(5):523–31. https://doi.org/10.1080/02841859809172219.

    Article  CAS  PubMed  Google Scholar 

  101. Kuhn JP, Berger PE. Computed tomographic diagnosis of osteomyelitis. Radiology. 1979;130(2):503–6. https://doi.org/10.1148/130.2.503.

    Article  CAS  PubMed  Google Scholar 

  102. Gold RH, Hawkins RA, Katz RD. Bacterial osteomyelitis: findings on plain radiography, CT, MR, and scintigraphy. AJR Am J Roentgenol. 1991;157(2):365–70. https://doi.org/10.2214/ajr.157.2.1853823.

    Article  CAS  PubMed  Google Scholar 

  103. Daoud A, Saighi-Bouaouina A. Treatment of sequestra, pseudarthroses, and defects in the long bones of children who have chronic hematogenous osteomyelitis. J Bone Joint Surg Am. 1989;71(10):1448–68.

    Article  CAS  PubMed  Google Scholar 

  104. Spiegel D, Penny J. Chronic osteomyelitis in children. Tech Orthop. 2005;20(2):142–52. Cited in: Journals@Ovid Full Text at http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=ovfth&NEWS=N&AN=00013611-200506000-00008. Accessed 31 Oct 2020

    Article  Google Scholar 

  105. Lopes TD, Reinus WR, Wilson AJ. Quantitative analysis of the plain radiographic appearance of Brodie’s abscess. Investig Radiol. 1997;32(1):51–8. https://doi.org/10.1097/00004424-199701000-00008.

    Article  CAS  Google Scholar 

  106. Wing VW, Jeffrey RB Jr, Federle MP, Helms CA, Trafton P. Chronic osteomyelitis examined by CT. Radiology. 1985;154(1):171–4. https://doi.org/10.1148/radiology.154.1.3964936.

    Article  CAS  PubMed  Google Scholar 

  107. Tumeh SS, Aliabadi P, Seltzer SE, Weissman BN, McNeil BJ. Chronic osteomyelitis: the relative roles of scintigrams, plain radiographs, and transmission computed tomography. Clin Nucl Med. 1988;13(10):710–5.

    Article  CAS  PubMed  Google Scholar 

  108. Quinn SF, Murray W, Clark RA, Cochran C. MR imaging of chronic osteomyelitis. J Comput Assist Tomogr. 1988;12(1):113–7. https://doi.org/10.1097/00004728-198801000-00022.

    Article  CAS  PubMed  Google Scholar 

  109. Mason MD, Zlatkin MB, Esterhai JL, Dalinka MK, Velchik MG, Kressel HY. Chronic complicated osteomyelitis of the lower extremity: evaluation with MR imaging. Radiology. 1989;173(2):355–9. https://doi.org/10.1148/radiology.173.2.2798868.

    Article  CAS  PubMed  Google Scholar 

  110. Jones HW, Harrison JW, Bates J, Evans GA, Lubega N. Radiologic classification of chronic hematogenous osteomyelitis in children. J Pediatr Orthop. 2009;29(7):822–7. https://doi.org/10.1097/BPO.0b013e3181b76933.

    Article  PubMed  Google Scholar 

  111. Al-Sheikh W, Sfakianakis GN, Mnaymneh W, et al. Subacute and chronic bone infections: diagnosis using In-111, Ga-67 and Tc-99m MDP bone scintigraphy, and radiography. Radiology. 1985;155(2):501–6. https://doi.org/10.1148/radiology.155.2.3157204.

    Article  CAS  PubMed  Google Scholar 

  112. Ledermann HP, Kaim A, Bongartz G, Steinbrich W. Pitfalls and limitations of magnetic resonance imaging in chronic posttraumatic osteomyelitis. Eur Radiol. 2000;10(11):1815–23. https://doi.org/10.1007/s003300000480.

    Article  CAS  PubMed  Google Scholar 

  113. Guhlmann A, Brecht-Krauss D, Suger G, et al. Chronic osteomyelitis: detection with FDG PET and correlation with histopathologic findings. Radiology. 1998;206(3):749–54. https://doi.org/10.1148/radiology.206.3.9494496.

    Article  CAS  PubMed  Google Scholar 

  114. Termaat MF, Raijmakers PG, Scholten HJ, Bakker FC, Patka P, Haarman HJ. The accuracy of diagnostic imaging for the assessment of chronic osteomyelitis: a systematic review and meta-analysis. J Bone Joint Surg Am. 2005;87(11):2464–71. https://doi.org/10.2106/JBJS.D.02691.

    Article  CAS  PubMed  Google Scholar 

  115. Prandini N, Lazzeri E, Rossi B, Erba P, Parisella MG, Signore A. Nuclear medicine imaging of bone infections. Nucl Med Commun. 2006;27(8):633–44. https://doi.org/10.1097/00006231-200608000-00006.

    Article  PubMed  Google Scholar 

  116. Wenter V, Müller JP, Albert NL, et al. The diagnostic value of [(18)F]FDG PET for the detection of chronic osteomyelitis and implant-associated infection. Eur J Nucl Med Mol Imaging. 2016;43(4):749–61. https://doi.org/10.1007/s00259-015-3221-4.

    Article  PubMed  Google Scholar 

  117. Warmann SW, Dittmann H, Seitz G, Bares R, Fuchs J, Schäfer JF. Follow-up of acute osteomyelitis in children: the possible role of PET/CT in selected cases. J Pediatr Surg. 2011;46(8):1550–6. https://doi.org/10.1016/j.jpedsurg.2010.11.037.

    Article  PubMed  Google Scholar 

  118. Palestro CJ. FDG-PET in musculoskeletal infections. Semin Nucl Med. 2013;43(5):367–76. https://doi.org/10.1053/j.semnuclmed.2013.04.006.

    Article  PubMed  Google Scholar 

  119. Chaudhry AA, Gul M, Gould E, Teng M, Baker K, Matthews R. Utility of positron emission tomography-magnetic resonance imaging in musculoskeletal imaging. World J Radiol. 2016;8(3):268–74. https://doi.org/10.4329/wjr.v8.i3.268.

    Article  PubMed  PubMed Central  Google Scholar 

  120. del Rosal T, Goycochea WA, Méndez-Echevarría A, et al. 18F-FDG PET/CT in the diagnosis of occult bacterial infections in children. Eur J Pediatr. 2013;172(8):1111–1115. https://doi.org/10.1007/s00431-013-1983-x.

  121. Jennin F, Bousson V, Parlier C, Jomaah N, Khanine V, Laredo JD. Bony sequestrum: a radiologic review. Skelet Radiol. 2011;40(8):963–75. https://doi.org/10.1007/s00256-010-0975-4.

    Article  Google Scholar 

  122. Laine JC, Denning JR, Riccio AI, Jo C, Joglar JM, Wimberly RL. The use of ultrasound in the management of septic arthritis of the hip. J Pediatr Orthop B. 2015;24(2):95–8. https://doi.org/10.1097/BPB.0000000000000134.

    Article  PubMed  Google Scholar 

  123. Shahid M, Holton C, O’Riordan S, Kraft JK. Sonography of musculoskeletal infection in children. Ultrasound. 2020;28(2):103–17. https://doi.org/10.1177/1742271X20901736.

    Article  PubMed  PubMed Central  Google Scholar 

  124. Sarwar ZU, DeFlorio R, Catanzano TM. Imaging of nontraumatic acute hip pain in children: multimodality approach with attention to the reduction of medical radiation exposure. Semin Ultrasound CT MR. 2014;35(4):394–408. https://doi.org/10.1053/j.sult.2014.05.001.

    Article  PubMed  Google Scholar 

  125. Plumb J, Mallin M, Bolte RG. The role of ultrasound in the emergency department evaluation of the acutely painful pediatric hip. Pediatr Emerg Care. 2015;31(1):54–61. https://doi.org/10.1097/PEC.0000000000000332.

    Article  PubMed  Google Scholar 

  126. Lee SK, Suh KJ, Kim YW, et al. Septic arthritis versus transient synovitis at MR imaging: preliminary assessment with signal intensity alterations in bone marrow. Radiology. 1999;211(2):459–65. https://doi.org/10.1148/radiology.211.2.r99ma47459.

    Article  CAS  PubMed  Google Scholar 

  127. Kwack KS, Cho JH, Lee JH, Cho JH, Oh KK, Kim SY. Septic arthritis versus transient synovitis of the hip: gadolinium-enhanced MRI finding of decreased perfusion at the femoral epiphysis. AJR Am J Roentgenol. 2007;189(2):437–45. https://doi.org/10.2214/AJR.07.2080.

    Article  PubMed  Google Scholar 

  128. Kim EY, Kwack KS, Cho JH, Lee DH, Yoon SH. Usefulness of dynamic contrast-enhanced MRI in differentiating between septic arthritis and transient synovitis in the hip joint. AJR Am J Roentgenol. 2012;198(2):428–33. https://doi.org/10.2214/AJR.11.6937.

    Article  PubMed  Google Scholar 

  129. Schallert EK, Kan JH, Monsalve J, Zhang W, Bisset GS 3rd, Rosenfeld S. Metaphyseal osteomyelitis in children: how often does MRI-documented joint effusion or epiphyseal extension of edema indicate coexisting septic arthritis? [published correction appears in Pediatr Radiol. 2016 May;46(5):734]. Pediatr Radiol. 2015;45(8):1174–81. https://doi.org/10.1007/s00247-015-3293-0.

    Article  PubMed  Google Scholar 

  130. Sweeney JP, Helms CA, Minagi H, Louie KW. The widened teardrop distance: a plain film indicator of hip joint effusion in adults. AJR Am J Roentgenol. 1987;149(1):117–9. https://doi.org/10.2214/ajr.149.1.117.

    Article  CAS  PubMed  Google Scholar 

  131. Betz RR, Cooperman DR, Wopperer JM, et al. Late sequelae of septic arthritis of the hip in infancy and childhood. J Pediatr Orthop. 1990;10(3):365–72. https://doi.org/10.1097/01241398-199005000-00014.

    Article  CAS  PubMed  Google Scholar 

  132. Fabry G, Meire E. Septic arthritis of the hip in children: poor results after late and inadequate treatment. J Pediatr Orthop. 1983;3(4):461–6. https://doi.org/10.1097/01241398-198309000-00008.

    Article  CAS  PubMed  Google Scholar 

  133. Choi IH, Pizzutillo PD, Bowen JR, Dragann R, Malhis T. Sequelae and reconstruction after septic arthritis of the hip in infants. J Bone Joint Surg Am. 1990;72(8):1150–65.

    Article  CAS  PubMed  Google Scholar 

  134. Forlin E, Milani C. Sequelae of septic arthritis of the hip in children: a new classification and a review of 41 hips. J Pediatr Orthop. 2008;28(5):524–8. https://doi.org/10.1097/BPO.0b013e31817bb079.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Columbia University Medical Center, New York, NY, USA

    Edward P. Fenlon III & Diego Jaramillo

  2. Riley Hospital for Children, Indiana University, Indianapolis, IN, USA

    Boaz Karmazyn

  3. Texas Health Presbyterian Hospital of Plano, Department of Radiology, Plano, TX, USA

    John Y. Kim

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  1. Edward P. Fenlon III
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  2. Boaz Karmazyn
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  3. John Y. Kim
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  4. Diego Jaramillo
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Correspondence to Edward P. Fenlon III .

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Editors and Affiliations

  1. Department of Radiology, 3NW, Children's Hospital of Philadelphia, Philadelphia, PA, USA

    Hansel J. Otero

  2. Department of Radiology, 3NW, Children's Hospital of Philadelphia, Philadelphia, PA, USA

    Summer L. Kaplan

  3. Dept Of Radiology, MCH Radiology, Miami Children's Hospital, Miami, FL, USA

    L Santiago Medina

  4. Dept of Radiology, Virginal Mason Medical Center, Seattle, WA, USA

    C. Craig Blackmore

  5. Zionsville, IN, USA

    Kimberly E Applegate

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Fenlon, E.P., Karmazyn, B., Kim, J.Y., Jaramillo, D. (2022). Hematogenous Osteomyelitis and Septic Arthritis in Children. In: Otero, H.J., Kaplan, S.L., Medina, L.S., Blackmore, C.C., Applegate, K.E. (eds) Evidence-Based Imaging in Pediatrics. Evidence-Based Imaging. Springer, Cham. https://doi.org/10.1007/978-3-030-38095-3_87-1

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