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Aptasensors for Cancerous Exosome Detection

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Extracellular Vesicles in Diagnosis and Therapy

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2504))

Abstract

Cancerous exosomes that carry multiple biomarkers are attractive targets for the early diagnosis and therapy of cancer. As one of the powerful molecular recognition tools, aptamers with excellent binding affinity and specificity toward biomarkers have been exploited to construct various aptamer-based biosensors (aptasensors) for exosome detection. Here, we review recent advances in aptasensors for the detection of cancerous exosomes. We first discuss the importance and potential of cancerous exosomes in cancer diagnosis and then summarize some conventional aptasensors from the perspective of biomarker recognition and signal collection strategies. Finally, we comment on the outlook for aptasensor research and new directions for cancerous exosome detection.

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Authors and Affiliations

  1. The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang, China

    Jin Li, Sitao Xie, Fengli Qu & Weihong Tan

  2. Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Collaborative Innovation Center for Chemistry and Molecular Medicine, Hunan University, Changsha, China

    Weihong Tan

  3. Institute of Molecular Medicine (IMM), Renji Hospital, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University, School of Medicine, and College of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China

    Weihong Tan

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  1. Jin Li
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  2. Sitao Xie
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  3. Fengli Qu
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  4. Weihong Tan
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Correspondence to Weihong Tan .

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Editors and Affiliations

  1. National Center for Global Health, Istituto Superiore di Sanità, Rome, Italy

    Maurizio Federico

  2. National Center for Global Health, Istituto Superiore di Sanità, Rome, Italy

    Barbara Ridolfi

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Li, J., Xie, S., Qu, F., Tan, W. (2022). Aptasensors for Cancerous Exosome Detection. In: Federico, M., Ridolfi, B. (eds) Extracellular Vesicles in Diagnosis and Therapy. Methods in Molecular Biology, vol 2504. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2341-1_1

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  • DOI: https://doi.org/10.1007/978-1-0716-2341-1_1

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