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Bcl2

Encyclopedia of Cancer

  • 42 Accesses

Synonyms

Apoptosis regulator Bcl2; B-cell CLL/lymphoma 2; B-cell leukemia/lymphoma-2 gene (Bcl-2); B-cell lymphoma protein 2; Bcl-2

Definition

The gene defined in the title of the entry as Bcl2 could be found written in different ways, with or without a line or a space between Bcl and 2. Just like any other gene, technically it should be italicized. In this entry, however, I decided to pay attention to specify whether I was referring to the gene or to the protein.

The Bcl2 family of proteins belong to a peculiar class of proteins regulating apoptosis, cell cycle, differentiation, and autophagy; in oncology, the genes coding for these proteins could not be defined neither as dominant transforming oncogenes (such as myc), nor tumor suppressor genes (such as p53). They could be best defined as apoptosis-related genes, a definition that stresses the importance of apoptosis (and of its dysregulation) in the genesis and development of cancer in humans and other species. Dysregulation of...

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References

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See Also

  • (2012) APAF-1. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 231. doi:10.1007/978-3-642-16483-5_344

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  • (2012) Autoimmune diseases. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 311. doi:10.1007/978-3-642-16483-5_473

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  • (2012) BAD. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, pp 337–338. doi:10.1007/978-3-642-16483-5_519

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  • (2012) BAK. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 338. doi:10.1007/978-3-642-16483-5_521

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  • (2012) BAX. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 350. doi:10.1007/978-3-642-16483-5_543

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  • (2012) Cell cycle. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 737. doi:10.1007/978-3-642-16483-5_994

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  • (2012) Ionizing radiation. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1907. doi:10.1007/978-3-642-16483-5_3139

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  • (2012) MYC family. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2426. doi:10.1007/978-3-642-16483-5_3922

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Authors and Affiliations

  1. Dream Master Laboratory, Chandler, AZ, USA

    Marco Ruggiero & John W. Anderson

Authors
  1. Marco Ruggiero
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  2. John W. Anderson
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Correspondence to Marco Ruggiero .

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Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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Ruggiero, M., Anderson, J.W. (2014). Bcl2. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_562-4

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_562-4

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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Chapter history

  1. Latest

    Bcl2
    Published:
    07 June 2017

    DOI: https://doi.org/10.1007/978-3-642-27841-9_562-5

  2. Original

    Bcl2
    Published:
    05 June 2015

    DOI: https://doi.org/10.1007/978-3-642-27841-9_562-4

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