Abstract
Many anti-inflammatory agents have been exploited for the treatment of inflammatory diseases by targeting the most potent proinflammatory cytokines including tumor necrosis factor (TNF) and interleukin-1 (IL-1). Theoretically, simultaneous neutralization or blocking two important inflammatory mediators might achieve a synergistic therapeutic effect. A recombinant fusion protein, TNFR2-Fc-IL-1ra (TFI), was developed as bifunctional inflammatory inhibitor. TFI was able to strongly neutralize TNF activity and to antagonize IL-1 receptor in the cell binding inhibition assays, suggesting that TFI could be used as a bifunctional ligand with enhanced anti-inflammatory effect.
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Acknowledgements
This work was supported by 863 grant 2012AA02A406 and State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences.
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Xie, B. (2014). One of the TNF Superfamily Members: Bifunctional Protein, TNFR2-Fc-IL-1ra. In: Bayry, J. (eds) The TNF Superfamily. Methods in Molecular Biology, vol 1155. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-0669-7_18
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DOI: https://doi.org/10.1007/978-1-4939-0669-7_18
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